1 research outputs found
Robust Construction of Supersmall Zwitterionic Micelles Based on Hyperbranched Polycarbonates Mediates High Tumor Accumulation
Despite the numerous advantages of nanomedicines, their
therapeutic
efficacy is hampered by biological barriers, including fast in vivo clearance, poor tumor accumulation, inefficient
penetration, and cellular uptake. Herein, cross-linked supersmall
micelles based on zwitterionic hyperbranched polycarbonates can overcome
these challenges for efficiently targeted drug delivery. Biodegradable
acryloyl/zwitterion-functionalized hyperbranched polycarbonates are
synthesized by a one-pot sequential reaction of Michael-type addition
and ring-opening polymerization, followed by controlled modification
with carboxybetaine thiol. Cross-linked supersmall zwitterionic micelles
(X-CBMs) are readily prepared by straightforward self-assembly and
UV cross-linking. X-CBMs exhibit prolonged blood circulation because
of their cross-linked structure and zwitterion decoration, which resist
protein corona formation and facilitate escaping RES recognition.
Combined with the advantage of supersmall size (7.0 nm), X-CBMs mediate
high tumor accumulation and deep penetration, which significantly
enhance the targeted antitumor outcome against the 4T1 tumor model
by administration of the paclitaxel (PTX) formulation (X-CBM@PTX)