Vuelo de Cóndor

The fast improvement of computer technologies has open way to the creation of realistic experiences within videogames in recent years, this has allowed the local and global video game design industry to grow quickly, making videogames a very powerful tool, both for Fun and leisure as for learning and development of psychological and cognitive skills, thanks to the gameplay factor, or also called "ludification", which engages the user to stay immersed in the experience. Vuelo De Condor proposes a narrative that rescues the Ecuadorian roots, personifying an experience about the freedom of the Andean condors in the surroundings of the snowy mountain Antisana and, at the same time, invigorates the value of this bird for Ecuador, the condor as a national bird which is in danger of extinction. Based on extensive study of the animal, as well as the habitat and surroundings; Theories of game design and user experience; And the use of several digital tools applied in order to provide the final user a game with a theoretical, technical, practical and conceptual basis.La rápida mejora de tecnologías informáticas ha dado paso a la creación de experiencias realistas dentro de los videojuegos en los últimos años, esto ha permitido que la industria de diseño de videojuegos tanto local como global crezca rápidamente volviendo a los videojuegos una herramienta muy poderosa tanto para diversión y ocio como para aprendizaje y desarrollo de habilidades psicológicas y cognitivas, gracias al factor de jugabilidad, o también denominado “ludificación”, lo cual engancha al usuario para que permanezca inmerso en la experiencia. Vuelo De Cóndor propone una narrativa que rescata las raíces ecuatorianas, personificándose en una experiencia sobre la libertad de los cóndores andinos en los alrededores del nevado Antisana y, a la vez, vigoriza el valor de esta ave para el Ecuador, el cóndor como un ave patriótica que se encuentra en peligro de extinción. Basándose en un amplio estudio del animal, así como de su hábitat y los alrededores; teorías de diseño de juegos y de experiencia de usuario; y el uso de varias herramientas digitales aplicadas para lograr brindar al usuario final un juego tenga un sustento tanto teórico, técnico, practico y conceptual

El mercadeo para comerciantes y microempresas

En la actualidad, la finalidad e interpretación del mercadeo en el sector comercial y micro empresarial se percibe como un gasto en el proceso de desarrollo, minimizando las ganancias esperadas por los socios o dueños, sin darse cuenta, que el mercadeo es una herramienta catalizadora que bien aplicada no representa una inversión muy alta, y si, tiene como finalidad construir relaciones redituables con los clientes actuales y futuros. Pero la realidad muestra que el mercadeo es una herramienta básica para el emprendimiento en el sector real y la aplicación de este no requiere invertir grandes cantidades de dinero en el desarrollo de las dichas actividades, en este documento encontrará los pasos y la manera de aplicación del marketing en una manera fácil y práctica de aplicar mezclando los cinco pasos fundamentales del mercadeo desde la idea del negocio hasta la manera en que puede posicionarse en el mercado, dejando como inquietud asta donde está dispuesto a llegar en la aplicación de la herramient

Reactions of HNO with Metal Porphyrins: Underscoring the Biological Relevance of HNO

Azanone (1 HNO, nitroxyl) shows interesting yet poorly understood chemical and biological effects. HNO has some overlapping properties with nitric oxide (NO), sharing its biological reactivity toward heme proteins, thiols, and oxygen. Despite this similarity, HNO and NO show significantly different pharmacological effects. The high reactivity of HNO means that studies must rely on the use of donor molecules such as trioxodinitrate (Angeli’s salt). It has been suggested that azanone could be an intermediate in several reactions and that it may be an enzymatically produced signaling molecule. The inherent difficulty in detecting its presence unequivocally prevents evidence from yielding definite answers. On the other hand, metalloporphyrins are widely used as chemical models of heme proteins, providing us with invaluable tools for the study of the coordination chemistry of small molecules, like NO, CO, and O2. Studies with transition metal porphyrins have shown diverse mechanistic, kinetic, structural, and reactive aspects related to the formation of nitrosyl complexes. Porphyrins are also widely used in technical applications, especially when coupled to a surface, where they can be used as electrochemical gas sensors. Given their versatility, they have not escaped their role as key players in chemical studies involving HNO. This Account presents the research performed during the last 10 years in our group concerning azanone reactions with iron, manganese, and cobalt porphyrins. We begin by describing their HNO trapping capabilities, which result in formation of the corresponding nitrosyl complexes. Kinetic and mechanistic studies of these reactions show two alternative operating mechanisms: reaction of the metal center with HNO or with the donor. Moreover, we have also shown that azanone can be stabilized by coordination to iron porphyrins using electron-attracting substituents attached to the porphyrin ring, which balance the negatively charged NO¯. Second, we describe an electrochemical HNO sensing device based on the covalent attachment of a cobalt porphyrin to gold. A surface effect affects the redox potentials and allows discrimination between HNO and NO. The reaction with the former is fast, efficient, and selective, lacking spurious signals due to the presence of reactive nitrogen and oxygen species. The sensor is both biologically compatible and highly sensitive (nanomolar). This time-resolved detection allows kinetic analysis of reactions producing HNO. The sensor thus offers excellent opportunities to be used in experiments looking for HNO. As examples, we present studies concerning (a) HNO donation capabilities of new HNO donors as assessed by the sensor, (b) HNO detection as an intermediate in O atom abstraction to nitrite by phosphines, and (c) NO to HNO interconversion mediated by alcohols and thiols. Finally, we briefly discuss the key experiments required to demonstrate endogenous HNO formation to be done in the near future, involving the in vivo use of the HNO sensing device.Fil: Doctorovich, Fabio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: Bikiel, Damian Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: Pellegrino, Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: Suarez, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: Marti, Marcelo Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentin

LRD2: Low Resource Device Description for Energy Efficient Device Discovery

International audienceThe success of the large scale deployment of sensor actuator devices lies in their plug\&play capabilities: they should be automatically discovered and ready to be used when they join to an environment. Self-description and discovery gain therefore a particular importance. Nevertheless, there is currently no largely adopted energy efficient device description and discovery standard. Existing protocols use proprietary device description models and discovery mechanisms that are incompatible between the two. This paper presents LRD2 (Low Resource Device Description), a generic description model capable of describing different kinds of device information. LRD2 implements a compression algorithm to reduce the size of description documents, thus saving energy by reducing the number of messages sent in the network. Experimental results about the performance of LRD2 are also presented

El papel de los profesionales colombianos de relaciones públicas como agentes de transformación social: cómo la crisis del país obliga a los profesionales,a ir más allá de la comunicación con los públicos organizacionales

 América Latina ha experimentado altibajos económicos y políticos con impactos concurrentes sobre las organizaciones y la sociedad en general. Colombia no ha escapado a esta realidad y un componente violento empeora el clima social. Este trabajo resume los des-cubrimientos de un proyecto de investigación cualitativo y cuantitativo realizado en Colombia entre julio y diciembre de 2002. Tres grupos de ‘enfoque, 13 entrevistas de profundidad y una encuesta fueron conducidos en Medellín, Cali y Bogotá para entender el papel social de los profesionales colombianos de relaciones publicas. La fundamentación teórica para la investigación fue la perspectiva que describe la Escuela Latinoamericana de Relaciones Públicas, presentada a la comunidad académica internacional por Molleda en 2001-2002. El primer estudio comprensivo fue realizado en Brasil. En forma similar, un instrumento cuantitativo fue usado para medir las opiniones acerca del papel social de las Relaciones Públicas de un mayor número de practicantes (n= 166) quienes son miembros del Centro Colombiano de Relaciones Públicas y Comunicación Organizacional (CECORP). Este estudio, además, apoya la existencia de cuatro dimensiones de papel social: “Ética y Responsabilidad Social”, “El Bienestar del Empleado”, “El Bienestar de la Comunidad” y “La Armonía con el Gobierno”. Años de experiencia profesional y la educación universitaria están positivamente correlacionadas con la promulgación de las actividades de “Ética y Responsabilidad Social” y, ambos, la comunidad y los factores del gobierno, con el papel social de las Relaciones Públicas en Colombia

Personalized Temporal Medical Alert System

International audienceThe continuous increasing needs in telemedicine and healthcare, accentuate the need of well-adapted medical alert systems. Such alert systems may be used by a variety of patients and medical actors, and should allow monitoring a wide range of medical variables. This paper proposes Tempas, a personalized temporal alert system. It facilitates customized alert configuration by using linguistic trends. The trend detection algorithm is based on data normalization, time series segmentation, and segment classification. It improves state of the art by treating irregular and regular time series in an appropriate way, thanks to the introduction of an observation variable valid time. Alert detection is enriched with quality and applicability measures. They allow a personalized tuning of the system to help reducing false negatives and false positives alert

The Practice of Overlapping Surgery Is Safe in Total Knee and Hip Arthroplasty

Background: Overlapping surgery occurs when a surgeon performs 2 procedures in an overlapping time frame. This practice is commonplace in the setting of total joint arthroplasty and is intended to increase patient access to experienced surgeons, improve efficiency, and advance the surgical competence of surgeons and trainees. The practice of overlapping surgery has been questioned because of safety and ethical concerns. As the literature is scarce on this issue, we evaluated the unplanned hospital readmission and reoperation rates associated with overlapping and non-overlapping total joint arthroplasty procedures. Methods: We reviewed 3,290 consecutive primary total knee and hip arthroplasty procedures that had been performed between November 2010 and July 2016 by 2 fellowship-trained senior surgeons at a single institution. Overlapping surgery was defined as the practice in which the attending surgeon performed a separate procedure in another room with an overlapping room time of at least 30 minutes. Patient baseline characteristics and 90-day rates of complications, readmissions, and reoperations were compared between overlapping and non-overlapping procedures. Subanalyses also were done on patients with a body mass index (BMI) of ≥30 kg/m2 and those with an American Society of Anesthesiologists (ASA) score of 3 or 4. The level of significance was set at 0.05. Results: Of the 2,833 procedures that met the inclusion criteria, 57% (1,610) were overlapping and 43% (1,223) were non-overlapping. Baseline demographics, BMI, and ASA scores were similar between the groups. No significant differences were found between the overlapping and non-overlapping procedures in terms of the 90-day rates of complications (5.2% vs. 6.6%, respectively; p = 0.104), unplanned readmissions (3.4% vs. 4.3%; p = 0.235), or reoperations (3.1 vs. 3.1; p = 1.0) in the analysis of the entire cohort or in subgroup analyses of obese patients and patients with an ASA score of 3 or 4. The total mean operating room time was 5.8 minutes higher for overlapping procedures. Conclusions: Overlapping procedures showed no increase in terms of the 90-day rates of complications, readmissions, or reoperations when compared with non-overlapping procedures. There was just over a 5-minute increase in mean operating room time for overlapping procedures. Our data suggest that overlapping surgery does not lead to detrimental outcomes following total knee arthroplasty or total hip arthroplasty. Future investigations evaluating patient-oriented outcomes and satisfaction are warranted. Level of Evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence