Mission Doctors\u27 Association in Rhodesia

Shortly before receiving confirmation of his request for a second mission tour in Silveria Mission, Fort Victoria, Rhodesia, Central Africa, Dr. Richard Stoughton recorded a tape for members of the Mission Doctors\u27 Association (his sponsoring group) in which he thanked them for continued support, told of his work and gave some of the rationale for his requesting the second, three-year tour of duty. The article which follows consists of excerpts from the transcript of Dr. Stoughton\u27s January, 1972, tape to the MDA

Effect of Puromycin on Mitotic Index, Amino Acid Incorporation and Dna Synthesis of Epidermal Cells

Puromycin 200 mg/kg given systemically will block DNA synthesis, amino acid incorporation and mitosis in the epidermis of the baby rat. Topically applied solutions of 1% puromycin did not have any effect on uptake of H3 thymidine or on mitosis of the epidermal cells. H3-puromycin given intraperitoneally was demonstrated in the epidermal cells by radioautographs but no evidence of labeling of epidermal cells was found by topical application

Hubble Space Telescope Imaging of Bright Lyman-break Galaxy Candidates from the Sloan Digital Sky Survey: Not LBGs After All

We present deep Hubble Space Telescope ACS and NICMOS images of six bright Lyman-break galaxy candidates that were previously discovered in the Sloan Digital Sky Survey. We find that five of the objects are consistent with unresolved point sources. Although somewhat atypical of the class, they are most likely LoBAL quasars, perhaps FeLoBALs. The sixth object, J1147, has a faint companion galaxy located ~0.8 arcsec to the southwest. The companion contributes ~8% of the flux in the observed-frame optical and infrared. It is unknown whether this companion is located at the same redshift as J1147.Comment: 16 pages, 8 figures, 3 tables; accepted for publication in A

Urine Orotic Acid-Orotidine Levels in Azaribine-Treated Patients with Psoriasis

Azaribine, as a pyrimidine analog, blocks the decarboxylase conversion of orotidylic acid to uridine monophosphate with a resultant excretion of accumulated orotic acid and orotidine in the urine. Patients treated with azaribine may develop transitory, severe central nervous system symptoms of depression, lethargy, and ataxia. These side effects are not predictable from oral dosage, and blood levels of the drug are very difficult to determine. All of our psoriatic patients treated with azaribine excreted large but variable amounts of orotic acid-orotidine in the urine. Spot urine ratios of orotic acid-orotidine:creatinine correlated very well with measured 24-hr urine output of orotic acid-orotidine. Patients with central nervous system symptoms were found to have very high urine levels of orotic acid orotidine. These symptoms can be prevented by monitoring the urinary orotic acid-orotidine:creatinine ratio levels and keeping them within a range which is still compatible with successful management of the psoriatic lesions

The effects of charge transfer inefficiency (CTI) on galaxy shape measurements

(Abridged) We examine the effects of charge transfer inefficiency (CTI) during CCD readout on galaxy shape measurements required by studies of weak gravitational lensing. We simulate a CCD readout with CTI such as that caused by charged particle radiation damage. We verify our simulations on data from laboratory-irradiated CCDs. Only charge traps with time constants of the same order as the time between row transfers during readout affect galaxy shape measurements. We characterize the effects of CTI on various galaxy populations. We baseline our study around p-channel CCDs that have been shown to have charge transfer efficiency up to an order of magnitude better than several models of n-channel CCDs designed for space applications. We predict that for galaxies furthest from the readout registers, bias in the measurement of galaxy shapes, Delta(e), will increase at a rate of 2.65 +/- 0.02 x 10^(-4) per year at L2 for accumulated radiation exposure averaged over the solar cycle. If uncorrected, this will consume the entire shape measurement error budget of a dark energy mission within about 4 years. Software mitigation techniques demonstrated elsewhere can reduce this by a factor of ~10, bringing the effect well below mission requirements. CCDs with higher CTI than the ones we studeied may not meet the requirements of future dark energy missions. We discuss ways in which hardware could be designed to further minimize the impact of CTI.Comment: 11 pages, 6 figures, and 2 tables. Accepted for publication in PAS

First measurements of high frequency cross-spectra from a pair of large Michelson interferometers

Measurements are reported of the cross-correlation of spectra of differential position signals from the Fermilab Holometer, a pair of co-located 39 m long, high power Michelson interferometers with flat, broadband frequency response in the MHz range. The instrument obtains sensitivity to high frequency correlated signals far exceeding any previous measurement in a broad frequency band extending beyond the 3.8 MHz inverse light crossing time of the apparatus. The dominant but uncorrelated shot noise is averaged down over $2\times 10^8$ independent spectral measurements with 381 Hz frequency resolution to obtain $2.1\times 10^{-20} \ \mathrm{m}/\sqrt{\mathrm{Hz}}$ sensitivity to stationary signals. For signal bandwidths $\Delta f > 11$ kHz, the sensitivity to strain $h$ or shear power spectral density of classical or exotic origin surpasses a milestone $PSD_{\delta h} < t_p$ where $t_p= 5.39\times 10^{-44}/\mathrm{Hz}$ is the Planck time.Comment: 5 pages, 3 figure

Interferometric Constraints on Quantum Geometrical Shear Noise Correlations

Final measurements and analysis are reported from the first-generation Holometer, the first instrument capable of measuring correlated variations in space-time position at strain noise power spectral densities smaller than a Planck time. The apparatus consists of two co-located, but independent and isolated, 40 m power-recycled Michelson interferometers, whose outputs are cross-correlated to 25 MHz. The data are sensitive to correlations of differential position across the apparatus over a broad band of frequencies up to and exceeding the inverse light crossing time, 7.6 MHz. By measuring with Planck precision the correlation of position variations at spacelike separations, the Holometer searches for faint, irreducible correlated position noise backgrounds predicted by some models of quantum space-time geometry. The first-generation optical layout is sensitive to quantum geometrical noise correlations with shear symmetry---those that can be interpreted as a fundamental noncommutativity of space-time position in orthogonal directions. General experimental constraints are placed on parameters of a set of models of spatial shear noise correlations, with a sensitivity that exceeds the Planck-scale holographic information bound on position states by a large factor. This result significantly extends the upper limits placed on models of directional noncommutativity by currently operating gravitational wave observatories.Comment: Matches the journal accepted versio

Galaxy Clustering Topology in the Sloan Digital Sky Survey Main Galaxy Sample: a Test for Galaxy Formation Models

We measure the topology of the main galaxy distribution using the Seventh Data Release of the Sloan Digital Sky Survey, examining the dependence of galaxy clustering topology on galaxy properties. The observational results are used to test galaxy formation models. A volume-limited sample defined by $M_r<-20.19$ enables us to measure the genus curve with amplitude of $G=378$ at $6h^{-1}$Mpc smoothing scale, with 4.8\% uncertainty including all systematics and cosmic variance. The clustering topology over the smoothing length interval from 6 to $10 h^{-1}$Mpc reveals a mild scale-dependence for the shift ($\Delta\nu$) and void abundance ($A_V$) parameters of the genus curve. We find substantial bias in the topology of galaxy clustering with respect to the predicted topology of the matter distribution, which varies with luminosity, morphology, color, and the smoothing scale of the density field. The distribution of relatively brighter galaxies shows a greater prevalence of isolated clusters and more percolated voids. Even though early (late)-type galaxies show topology similar to that of red (blue) galaxies, the morphology dependence of topology is not identical to the color dependence. In particular, the void abundance parameter $A_V$ depends on morphology more strongly than on color. We test five galaxy assignment schemes applied to cosmological N-body simulations of a $\Lambda$CDM universe to generate mock galaxies: the Halo-Galaxy one-to-one Correspondence model, the Halo Occupation Distribution model, and three implementations of Semi-Analytic Models (SAMs). None of the models reproduces all aspects of the observed clustering topology; the deviations vary from one model to another but include statistically significant discrepancies in the abundance of isolated voids or isolated clusters and the amplitude and overall shift of the genus curve. (Abridged)Comment: 24 pages, 19 figures, 10 tables, submitted to ApJS. Version with full resolution images is available at http://astro.kias.re.kr/~cbp/doc/dr7Topo.pd

The Evolution of [OII] Emission from Cluster Galaxies

We investigate the evolution of the star formation rate in cluster galaxies. We complement data from the CNOC1 cluster survey (0.15<z<0.6) with measurements from galaxy clusters in the 2dF galaxy redshift survey (0.05<z<0.1) and measurements from recently published work on higher redshift clusters, up to almost z=1. We focus our attention on galaxies in the cluster core, ie. galaxies with r<0.7h^{-1}_{70}Mpc. Averaging over clusters in redshift bins, we find that the fraction of galaxies with strong [OII] emission is < 20% in cluster cores, and the fraction evolves little with redshift. In contrast, field galaxies from the survey show a very strong increase over the same redshift range. It thus appears that the environment in the cores of rich clusters is hostile to star formation at all the redshifts studied. We compare this result with the evolution of the colours of galaxies in cluster cores, first reported by Butcher & Oemler (1984). Using the same galaxies for our analysis of the [OII] emission, we confirm that the fraction of blue galaxies, which are defined as galaxies 0.2 mag bluer in the rest frame B-V than the red sequence of each cluster, increases strongly with redshift. Since the colours of galaxies retain a memory of their recent star formation history, while emission from the [OII] line does not, we suggest that these two results can best be reconciled if the rate at which the clusters are being assembled is higher in the past, and the galaxies from which it is being assembled are typically bluer.Comment: 8 pages, 7 figures, accepted for publication in MNRA