909 research outputs found
Numerical simulation of sloshing in liquid storing tanks by an arbitrary Lagrangian-Eulerian strategy
La agitación de fluidos contenidos en tanques de almacenamiento con superficie libre es numéricamente simulada mediante una formulación lagrangiana-euleriana arbitraria. El fluido es considerado viscoso y de comportamiento newtoniano, mientras que el flujo se asume laminar e incompresible. Se emplea un código computacional particionado y distribuido, que resuelve tres instancias en cada paso de tiempo: (i) la determinación del estado en el fluido, representado por las ecuaciones de Navier–Stokes; (ii) el desplazamiento de la superficie libre; y (iii) la actualización de la posición de los nodos interiores de la malla de elementos finitos, que es deformada como consecuencia del desplazamiento de la superficie libre. El propósito del trabajo es verificar la aplicabilidad del método en problemas de agitación de solución conocida, así como también resolver algunos ejemplos prácticos. Los ejemplos numéricos incluyen la validación con soluciones analíticas, en las cuales el período de la onda y la tasa de amortiguamiento viscoso son bien capturadas, comparaciones con soluciones de referencia tomadas de otros autores y un caso de agitación inducida por acción sísmica.Sloshing of fluids with a free surface contained in liquid storage tanks is numerically simulated by an arbitrary Lagrangian-Eulerian formulation. The fluid is considered viscous and Newtonian, while the flow is assumed laminar and incompressible. A partitioned and distributed computational code is employed, which solves three instances each time step: (i) the determination of the fluid state, given by the Navier–Stokes equations; (ii) the displacement of the free surface; and (iii) the update of the position of the internal nodes of the mesh, that is deformed as a consequence of the free surface displacement. The purpose of the work is verifying the applicability of the method to sloshing problems with known solutions, as well as the resolution of some practical examples. Numerical examples include validations against analytical solutions, where the wave period and damping rate are well captured, comparisons with reference results from other authors and a sample of sloshing induced by seismic actions.Peer Reviewe
The 2013 Lunigiana (Central Italy) earthquake: Seismic source analysis from DInSar and seismological data, and geodynamic implications for the northern Apennines. A discussion
We refine the geological data of the 2013 Lunigiana EQ of Pezzo et al. (2014)
We report structural constraints for the seismic source of the 2013 Lunigiana EQ.
We underline the role of tectonic inheritance for the seismogenic faul
FBR for Polyolefin Production in Gas Phase: Validation of a Two-phase Compartmentalized Model by Comparison with CFD
Two different modeling approaches are applied in this work to the simulation of fluidized bed reactors containing solid particles of Geldart A-B type and operated at conditions typically used for polyolefins production. On one side, a fully detailed computational fluid dynamics (CFD) model is developed, considering a 2D planar geometry and a multi-fluid description with kinetic theory of granular flows. On the other, a conventional three-phase, 1D compartmentalized model (SCM) is also developed, implementing the fluid dynamic description based on popular, semi-empirical relationships available in the literature. Given the huge difference of computational effort associated with the corresponding numerical solutions, our aim is to confirm the reliability of the simplified model by comparison with the results of the detailed CFD model. The comparison is carried out considering the fluidization of a bed of solid particles without reaction and solid injection or withdrawal, thus focusing on the steady-state fluid dynamic behavior of the expanded bed. Three different gas velocities and different monodisperse and polydisperse particle populations are analyzed.
The results show that the oversimplified compartmentalized approach is capable to predict the solid mixing features established inside the reactor operated in bubbling fluidization regime with good reliability for non-reactive polyethylene particles. Average solid volume fractions are particularly close to the values predicted by the CFD model when monodisperse particles are considered inside the examined range of gas velocity values. A generally good agreement is also found when solids with broad size distribution are analyzed. Overall, these comparisons provide a meaningful validation of the simplified compartmentalized models: given their negligible computational demand and general versatility (complex kinetic schemes and single particle models are easily accounted for), they still represent an effective tool of industrial process design
Intravesical oxybutynin: mode of action assessed by passive diffusion and electromotive administration with pharmacokinetics of oxybutynin and N-desethyl oxybutynin.
PURPOSE: A proportion of patients with detrusor hyperreflexia who are unresponsive to oral oxybutynin often benefit from intravesical oxybutynin instillation. To our knowledge the precise mode of action of this method is obscure.
MATERIALS AND METHODS: In 12 patients with detrusor hyperreflexia who were previously unresponsive to oral and intravesical passive diffusion of 5 mg. oxybutynin we administered 5 mg. oxybutynin orally as well as increased doses of 15 mg. oxybutynin intravesically with passive diffusion and with 15 mA. associated electric current. Each administration mode per patient was associated with an 8-hour urodynamic monitoring session during which oxybutynin and N-desethyl oxybutynin plasma levels, and intravesical oxybutynin uptake were measured.
RESULTS: A dose of 5 mg. oxybutynin orally induced no urodynamic improvement with an area under the plasma concentration time curve of combined N-desethyl oxybutynin plus oxybutynin of 16,297 ng./8 hours and an area under the curve ratio of N-desethyl oxybutynin-to-oxybutynin of 11:1. Passive diffusion oxybutynin resulted in 12 mg. oxybutynin intravesical uptake and significant improvement in 3 of 8 urodynamic measurements, although the area under the curve of combined N-desethyl oxybutynin plus oxybutynin was only 2,123 ng./8 hours and the N-desethyl oxybutynin-to-oxybutynin ratio was 1.1:1.0. Electromotive administration of oxybutynin resulted in almost complete intravesical uptake of the 15 mg. dose, significant improvement in all 8 urodynamic measurements and an increased oxybutynin level versus oral and passive diffusion, although the area under the curve of combined N-desethyl oxybutynin plus oxybutynin was 4,574 ng./8 hours and the N-desethyl oxybutynin-to-oxybutynin ratio was inverted at 1.0:1.4. The oral dose of 5 mg. oxybutynin caused anticholinergic side effects in 8 of the 12 patients. Neither intravesical passive diffusion nor electromotive administration caused side effects with an uptake of 12 and 15 mg., respectively.
CONCLUSIONS: A large proportion of intravesical oxybutynin is sequestered, probably in the urothelium. Intravesical oxybutynin administration confers therapeutic benefits via localized direct action within the bladder wall.
Comment in
Intravesical treatment of bladder dysfunction. [J Urol. 2001
Comparison between detailed (CFD) and simplified models for the prediction of solid particle size distribution in fluidized bed reactors
This work is aimed at developing a simplified model suitable to effectively describe the fluidization behavior within fluidized beds with minimal computational efforts. The simplified model was validated through detailed CFD Euler-Euler simulations showing a good agreement in the case of large particles (about 450 micron) at all the gas velocities considered (20, 40, 61 cm/s). Slightly less accurate outcomes were observed for smaller particles (about 220 micron). This was due to the underestimation of the particle size effect on the fluidization behavior by the simplified approach
Experimental study of CO2 sequestration by ECBM recovery: the case of Sulcis coal.
An ECBM (Enhanced Coal Bed Methane) feasibility study started for the Sulcis Coal Province (SW Sardinia, Italy) in December 2004: geochemical, structural-geology, stratigraphic and reservoir engineering considerations are discussed. The first newly gathered experimental data are discussed, including: fluid geochemistry (major and minor elements, dissolved gases, C and He isotopic ratios) of the reservoir, coal composition and experimental data on CO2/CH4 adsorption on coal. A MapInfo GIS structure was built up including stratigraphical, geo-structural, hydrogeochemical, coal-compositional and environmental impact information as well as the CO2 sources location and typology. Even if these data could be preliminary with respect to the coal characteritics effectively located at the future injection depth, they highlighted both the challenging positive and negative aspects of the Sulcis Coal Province versus the exploitation of the ECBM technique. The most important objective of this phase I of the project is the selection of the best Sulcis ECBM test-pilot site, which will be followed (Phase II) by the choice of a scaled up site and possibly by a future network (Phase III). These phases are foreseen to be accompanied by the selection of progressively added CO2 industrial sources, to be used within the project economic spreadsheet model, actually in evolution.
CO2 geological storage and CH4 production potentials in Sulcis have been grossly evaluated as a whole, in the frame of the Sardinia region CO2 sources, including the coal-fired power plants, both existent and foreseen (hundreds of millions of tonns of CO2 are possible to be stored underground in the next decades). The reservoir estimates, both for the CO2 injection and for the CH4 production are clearly involving to start the test-site phase exploitation, in the frame of an auspicabile international operative project
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