Searching for Mergers in Early-Type QSO Host Galaxies and a Control Sample of Inactive Ellipticals

We present very deep HST/ACS images of five QSO host galaxies, classified as undisturbed ellipticals in earlier studies. For four of the five objects, our images reveal strong signs of interaction such as tidal tails, shells, and other fine structure, suggesting that a large fraction of QSO host galaxies may have experienced a relatively recent merger event. Our preliminary results for a control sample of inactive elliptical galaxies do not reveal comparable fine structure.Comment: 2 pages, 1 figure; To appear in the proceedings of IAU Symposium 245, "Formation and Evolution of Galaxy Bulges," M. Bureau, E. Athanassoula, and B. Barbuy, ed

Evidence for Merger Remnants in Early-Type Host Galaxies of Low-Redshift QSOs

We present results from a pilot HST ACS deep imaging study in broad-band V of five low-redshift QSO host galaxies classified in the literature as ellipticals. The aim of our study is to determine whether these early-type hosts formed at high redshift and have since evolved passively, or whether they have undergone relatively recent mergers that may be related to the triggering of the nuclear activity. We perform two-dimensional modeling of the light distributions to analyze the host galaxies' morphology. We find that, while each host galaxy is reasonably well fitted by a de Vaucouleurs profile, the majority of them (4/5) reveal significant fine structure such as shells and tidal tails. These structures contribute between ~5% and 10% to the total V-band luminosity of each host galaxy within a region of r ~ 3 r_eff and are indicative of merger events that occurred between a few hundred Myr and a Gyr ago. These timescales are comparable to starburst ages in the QSO hosts previously inferred from Keck spectroscopy. Our results thus support a consistent scenario in which most of the QSO host galaxies suffered mergers with accompanying starbursts that likely also triggered the QSO activity in some way, but we are also left with considerable uncertainty on physical mechanisms that might have delayed this triggering for several hundred Myr after the merger.Comment: 22 pages, 4 figures. Accepted for publication in the Astrophysical Journa

KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell–cell junctions

Cerebral cavernous malformation (CCM), a disease associated with defective endothelial junctions, result from autosomal dominant CCM1 mutations that cause loss of KRIT-1 protein function, though how the loss of KRIT-1 leads to CCM is obscure. KRIT-1 binds to Rap1, a guanosine triphosphatase that maintains the integrity of endothelial junctions. Here, we report that KRIT-1 protein is expressed in cultured arterial and venous endothelial cells and is present in cell–cell junctions. KRIT-1 colocalized and was physically associated with junctional proteins via its band 4.1/ezrin/radixin/moesin (FERM) domain. Rap1 activity regulated the junctional localization of KRIT-1 and its physical association with junction proteins. However, the association of the isolated KRIT-1 FERM domain was independent of Rap1. Small interfering RNA–mediated depletion of KRIT-1 blocked the ability of Rap1 to stabilize endothelial junctions associated with increased actin stress fibers. Thus, Rap1 increases KRIT-1 targeting to endothelial cell–cell junctions where it suppresses stress fibers and stabilizes junctional integrity

Spectacular Shells in the Host Galaxy of the QSO MC2 1635+119

We present deep HST/ACS images and Keck spectroscopy of MC2 1635+119, a QSO hosted by a galaxy previously classified as an undisturbed elliptical. Our new images reveal dramatic shell structure indicative of a merger event in the relatively recent past. The brightest shells in the central regions of the host are distributed alternately in radius, with at least two distinct shells on one side of the nucleus and three on the other, out to a distance of ~13 kpc. The light within the five shells comprises ~6% of the total galaxy light. Lower surface brightness ripples or tails and other debris extend out to a distance of ~65 kpc. A simple N-body model for a merger reproduces the inner shell structure and gives an estimate for the age of the merger between ~30 Myr and ~1.7 Gyr, depending on a range of reasonable assumptions. While the inner shell structure is suggestive of a minor merger, the total light contribution from the shells and extended structures are more indicative of a major merger. The spectrum of the host galaxy is dominated by a population of intermediate age (~1.4 Gyr), indicating a strong starburst episode that may have occurred at the time of the merger event. We speculate that the current QSO activity may have been triggered in the recent past by either a minor merger, or by debris from an older (~Gyr) major merger that is currently ``raining'' back into the central regions of the merger remnant.Comment: 14 pages, 5 figures. Accepted for publication in the Astrophysical Journa

Extending the Information Revolution

America has a grand opportunity to lay the foundations for a prosperous and secure future. Our task is not just reviving the weak economy or increasing security -- as important as those are. Real sustainable economic growth and international security will come from expanding the information revolution to all parts of our society. Metcalfe's Law states that the value of a network increases exponentially in relation to the number of users. The same is true for markets and economic activity. By leaving some behind -- both at home and around the world, we impoverish not only those individuals; we also impoverish ourselves. This paper lays out a series of recommendations in a number of areas from a number of experts. It is based on some shared principles:the critical importance of inclusion and true participation by all;technology is, and should be, a tool -- the means to an end, not the end itself;open and competitive economic systems work best;and a more economically prosperous world is a more secure world

Star Formation in QSO Host Galaxies

Many of the conditions that are necessary for starbursts appear to be important in the triggering of QSOs. However, it is still debatable whether starbursts are ubiquitously present in galaxies harboring QSOs. In this paper we review our current knowledge from observations of the role of starbursts in different types of QSOs. Post-starburst stellar populations are potentially present in the majority of QSO hosts. QSOs with far-infrared colors similar to those of ultraluminous infrared galaxies invariably reside in merging galaxies that have interaction-induced starbursts of a few hundred Myr or less. Similar, but dramatically more luminous post-starburst populations are found in the recently discovered class of QSOs known as post-starburst QSOs, or Q+A's. Both of these classes, however, comprise only a small fraction (10-15%) of the total QSO population. The so-called "red" QSOs generally suffer from strong extinction at optical wavelengths, making them ideal candidates for the study of hosts. Their stellar populations typically show a post-starburst component as well, though with a larger range of ages. Finally, optical "classical" QSO hosts show traces of major star formation episodes (typically involving >10% of the mass of the stellar component) in the more distant past (1-2 Gyr). These starbursts appear to be linked to past merger events. It remains to be determined whether these mergers were also responsible for triggering the QSO activity that we observe today.Comment: 8 pages, 5 figures, invited review for "QSO Host Galaxies: Evolution and Environment", held at the Lorentz Center, Universiteit Leiden, August, 200

Detection of Galactic Center source G2 at 3.8 μ\mum during periapse passage

We report new observations of the Galactic Center source G2 from the W. M. Keck Observatory. G2 is a dusty red object associated with gas that shows tidal interactions as it nears closest approach with the Galaxy's central black hole. Our observations, conducted as G2 passed through periapse, were designed to test the proposal that G2 is a 3 earth mass gas cloud. Such a cloud should be tidally disrupted during periapse passage. The data were obtained using the Keck II laser guide star adaptive optics system (LGSAO) and the facility near-infrared camera (NIRC2) through the K' [2.1 $\mu$m] and L' [3.8 $\mu$m] broadband filters. Several results emerge from these observations: 1) G2 has survived its closest approach to the black hole as a compact, unresolved source at L'; 2) G2's L' brightness measurements are consistent with those over the last decade; 3) G2's motion continues to be consistent with a Keplerian model. These results rule out G2 as a pure gas cloud and imply that G2 has a central star. This star has a luminosity of $\sim$30 $L_{\odot}$ and is surrounded by a large ($\sim$2.6 AU) optically thick dust shell. The differences between the L' and Br-$\gamma$ observations can be understood with a model in which L' and Br-$\gamma$ emission arises primarily from internal and external heating, respectively. We suggest that G2 is a binary star merger product and will ultimately appear similar to the B-stars that are tightly clustered around the black hole (the so-called S-star cluster).Comment: Accepted by ApJ Letters, 2014 October 1

PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation

P21-activated kinases (PAKs) are multifunctional effectors of Rho GTPases with both kinase and scaffolding activity. Here, we investigated the effects of inflammation on PAK1 signaling and its role in colitis-driven carcinogenesis. PAK1 and p-PAK1 (Thr423) were assessed by immunohistochemistry, immunofluorescence, and Western blot. C57BL6/J wildtype mice were treated with a single intraperitoneal TNFα injection. Small intestinal organoids from these mice and from PAK1-KO mice were cultured with TNFα. NF-κB and PPARγ were analyzed upon PAK1 overexpression and silencing for transcriptional/translational regulation. PAK1 expression and activation was increased on the luminal intestinal epithelial surface in inflammatory bowel disease and colitis-associated cancer. PAK1 was phosphorylated upon treatment with IFNγ, IL-1β, and TNFα. In vivo, mice administered with TNFα showed increased p-PAK1 in intestinal villi, which was associated with nuclear p65 and NF-κB activation. p65 nuclear translocation downstream of TNFα was strongly inhibited in PAK1-KO small intestinal organoids. PAK1 overexpression induced a PAK1–p65 interaction as visualized by co-immunoprecipitation, nuclear translocation, and increased NF-κB transactivation, all of which were impeded by kinase-dead PAK1. Moreover, PAK1 overexpression downregulated PPARγ and mesalamine recovered PPARγ through PAK1 inhibition. On the other hand PAK1 silencing inhibited NF-κB, which was recovered using BADGE, a PPARγ antagonist. Altogether these data demonstrate that PAK1 overexpression and activation in inflammation and colitis-associated cancer promote NF-κB activity via suppression of PPARγ in intestinal epithelial cells