Revisiting the Perfluorinated Trityl Cation

Although ultimately not isolable for X-ray structural characterization, the free perfluorinated trityl cation was shown to be observable in neat triflic acid, which represents milder conditions than previous reports of this cation in “magic acid” or oleum. A triflate-bound species could be generated in organic solvents using stoichiometric amounts of triflic acid and was shown to be synthetically viable for hydride abstraction from Et SiH. It was demonstrated that the para-position on the -C F rings is the primary point of attack for decomposition of the cation. 3 6 5</p

Revisiting the Perfluorinated Trityl Cation

Although ultimately not isolable for X-ray structural characterization, the free perfluorinated trityl cation was shown to be observable in neat triflic acid, which represents milder conditions than previous reports of this cation in “magic acid” or oleum. A triflate-bound species could be generated in organic solvents using stoichiometric amounts of triflic acid and was shown to be synthetically viable for hydride abstraction from Et SiH. It was demonstrated that the para-position on the -C F rings is the primary point of attack for decomposition of the cation. 3 6 5</p

MOESM1 of Automated volumetric breast density measures: differential change between breasts in women with and without breast cancer

Additional file 1. Supplementary tables

SNPs representing loci associated with circulating SHBG concentrations.

<p>All SNPs are on the+strand and positions are based on build 36. EAF = ‘effect allele frequency’. Beta units are per-allele effect estimates in natural log transformed nmol/L. Sex column gives the sex with the largest per-allele beta estimate. Missing values for conditional SNPs as sex-specific conditional analysis was not performed.</p

Summary of the analytic plan.

<p>Summary of the analytic plan.</p

Statistically independent signals at the <i>SHBG</i> gene locus.

<p>All SNPs are on the+strand and positions are based on build 36. EAF = ‘effect allele frequency’. Beta units are per-allele effect estimates in natural log transformed nmol/L. ‘Full model’ SNPs were all included in a single regression model, where the effect estimates for each SNP are adjusted for the effect of the others in the model.</p><p>‘Conditional’ SNPs are SNPs with low pair-wise LD (HapMap r²<0.01) that were identified after conditioning on the full model SNPs.</p

Manhattan plot of the autosomal SNPs identified in the GWA meta-analysis.

<p>The Manhattan plot depicts the SNPs identified in the GWAS analysis labeled with the nearest gene on the plot. The SNP identified on the X chromosome, rs1573036, at Xq22.3, is not included in this figure.</p

Allelic heterogeneity at the <i>SHBG</i> gene locus.

<p>There was significant allelic heterogeneity at the SHBG gene locus. The nine independent signals identified in the SHBG gene are shown in relation to their position within the gene. All positions based on build 36. Not all genes are shown.</p