Manajemen Program Siaran Lokal Aceh TV Dalam Upaya Penyebarluasan Syariat Islam Dan Pelestarian Budaya Lokal

Managing broadcasting management is not easy. Managing the broadcasting business is a difficult and challenging. This research aims to analyze the activity of management and organizational performance ACEH TV television media in an effort to disseminate the Islamic Sharia and Preservation of Local Culture in Aceh. This research is descriptive qualitative. Informants of this research is managing director, program director, executive producer, cameraman / reporter, as well as additional informants Regional Chairman of the Indonesian Broadcasting Commission (KPID) Aceh, Aceh Province Department of Islamic Law, and local media observers. The location of this research is in Banda Aceh, Aceh province. Sampling was done purposively. Data collected through observation, interviews, and documentation. Data were analyzed by analysis of an interactive model of Miles and Huberman. The results showed that the ACEH TV as the medium of television that is broadcasting management ACEH have done according to a local television broadcasting standard. Agenda setting function of mass media performed in the ACEH TV dissemination of Islamic Shariah in Aceh and local culture to influence the people of Aceh to implement Islamic Sharia and also maintain the culture and local wisdom Aceh. It can be seen from all the programs that are aired ACEH TV is a program of local cultural nuances of Islamic law. There are still some shortcomings in running broadcasting broadcasting technology such as lack of equipment that is increasingly sophisticated. The results of image editing is very simple, and some programs presenter still looks stiff when in front of the camera

Crystal Design Approaches for the Synthesis of Paracetamol Co-Crystals

Crystal engineering principles were used to design three new co-crystals of paracetamol. A variety of potential co-crystal formers were initially identified from a search of the Cambridge Structural Database for molecules with complementary hydrogen-bond forming functionalities. Subsequent screening by powder X-ray diffraction of the products of the reaction of this library of molecules with paracetamol led to the discovery of new binary crystalline phases of paracetamol with <i>trans</i>-1,4-diaminocyclohexane (<b>1</b>); <i>trans</i>-1,4-di­(4-pyridyl)­ethylene (<b>2</b>); and 1,2-bis­(4-pyridyl)­ethane (<b>3</b>). The co-crystals were characterized by IR spectroscopy, differential scanning calorimetry, and ¹H NMR spectroscopy. Single crystal X-ray structure analysis reveals that in all three co-crystals the co-crystal formers (CCF) are hydrogen bonded to the paracetamol molecules through O–H···N interactions. In co-crystals (<b>1</b>) and (<b>2</b>) the CCFs are interleaved between the chains of paracetamol molecules, while in co-crystal (<b>3</b>) there is an additional N–H···N hydrogen bond between the two components. A hierarchy of hydrogen bond formation is observed in which the best donor in the system, the phenolic O–H group of paracetamol, is preferentially hydrogen bonded to the best acceptor, the basic nitrogen atom of the co-crystal former. The geometric aspects of the hydrogen bonds in co-crystals <b>1</b>–<b>3</b> are discussed in terms of their electrostatic and charge-transfer components

Crystal Design Approaches for the Synthesis of Paracetamol Co-Crystals

Crystal engineering principles were used to design three new co-crystals of paracetamol. A variety of potential co-crystal formers were initially identified from a search of the Cambridge Structural Database for molecules with complementary hydrogen-bond forming functionalities. Subsequent screening by powder X-ray diffraction of the products of the reaction of this library of molecules with paracetamol led to the discovery of new binary crystalline phases of paracetamol with <i>trans</i>-1,4-diaminocyclohexane (<b>1</b>); <i>trans</i>-1,4-di­(4-pyridyl)­ethylene (<b>2</b>); and 1,2-bis­(4-pyridyl)­ethane (<b>3</b>). The co-crystals were characterized by IR spectroscopy, differential scanning calorimetry, and ¹H NMR spectroscopy. Single crystal X-ray structure analysis reveals that in all three co-crystals the co-crystal formers (CCF) are hydrogen bonded to the paracetamol molecules through O–H···N interactions. In co-crystals (<b>1</b>) and (<b>2</b>) the CCFs are interleaved between the chains of paracetamol molecules, while in co-crystal (<b>3</b>) there is an additional N–H···N hydrogen bond between the two components. A hierarchy of hydrogen bond formation is observed in which the best donor in the system, the phenolic O–H group of paracetamol, is preferentially hydrogen bonded to the best acceptor, the basic nitrogen atom of the co-crystal former. The geometric aspects of the hydrogen bonds in co-crystals <b>1</b>–<b>3</b> are discussed in terms of their electrostatic and charge-transfer components

Crystal Design Approaches for the Synthesis of Paracetamol Co-Crystals

Crystal engineering principles were used to design three new co-crystals of paracetamol. A variety of potential co-crystal formers were initially identified from a search of the Cambridge Structural Database for molecules with complementary hydrogen-bond forming functionalities. Subsequent screening by powder X-ray diffraction of the products of the reaction of this library of molecules with paracetamol led to the discovery of new binary crystalline phases of paracetamol with <i>trans</i>-1,4-diaminocyclohexane (<b>1</b>); <i>trans</i>-1,4-di­(4-pyridyl)­ethylene (<b>2</b>); and 1,2-bis­(4-pyridyl)­ethane (<b>3</b>). The co-crystals were characterized by IR spectroscopy, differential scanning calorimetry, and ¹H NMR spectroscopy. Single crystal X-ray structure analysis reveals that in all three co-crystals the co-crystal formers (CCF) are hydrogen bonded to the paracetamol molecules through O–H···N interactions. In co-crystals (<b>1</b>) and (<b>2</b>) the CCFs are interleaved between the chains of paracetamol molecules, while in co-crystal (<b>3</b>) there is an additional N–H···N hydrogen bond between the two components. A hierarchy of hydrogen bond formation is observed in which the best donor in the system, the phenolic O–H group of paracetamol, is preferentially hydrogen bonded to the best acceptor, the basic nitrogen atom of the co-crystal former. The geometric aspects of the hydrogen bonds in co-crystals <b>1</b>–<b>3</b> are discussed in terms of their electrostatic and charge-transfer components

Dose Titration of Pregabalin in Patients with Painful Diabetic Peripheral Neuropathy: Simulation Based on Observational Study Patients Enriched with Data from Randomized Studies

<p><b> </b></p><p><b> </b></p><p><b>Article full text</b></p><p><br></p><p>The full text of this article can be found here<b>.</b> <a href="https://link.springer.com/article/10.1007/s12325-018-0664-6">https://link.springer.com/article/10.1007/s12325-018-0664-6</a></p><p></p><p><br></p><p><b>Provide enhanced content for this article</b></p><p><br></p><p>If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <a href="http://www.medengine.com/Redeem/”mailto:[email protected]”"><b>[email protected]</b></a>.</p><p><br></p><p>The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.</p><p><br></p><p>Other enhanced features include, but are not limited to:</p><p><br></p><p>• Slide decks</p><p>• Videos and animations</p><p>• Audio abstracts</p><p> </p><p>• Audio slides</p><ul> </ul

Transcriptional turnover of liver expressed transcripts in rodents.

<p>(A) Primary liver tissue was isolated from Mmus and two other rodents whose lineage split from Mmus one million years (Mcas) or 13 to 19 million years (Rnor). Examples of a Mmus-specific (<i>locus7150</i>, left), <i>Mus</i> genus-conserved (<i>locus1400</i>, middle), and rodent conserved (<i>locus4179</i>, right) lncRNA locus and their corresponding neighbouring protein-coding genes are illustrated. H3K4me3 enrichment is shown against a green background track and RNAseq signature against a yellow background track. The height (y-axis) of each track corresponds to the read depth. Beneath the enrichment tracks is the Refseq genome annotation for this region (UCSC genome browser). The mammalian conservation track (UCSC genome browser) shows degree of placental mammal base pair conservation (20 species) and sequence conservation. The syntenic positions of the predicted TSS of ncRNAs and neighbouring protein-coding loci are traced between species with dashed red lines. (B) H3K4me3 enriched regions (black: H3K4me3 bound DNA reads and white: no ChIPseq reads) within 5 kb of the peak summit for all identified intergenic lncRNA (one per line, categories I to V) and 136 randomly sampled protein-coding loci (category VI). Categories represent intergenic lncRNA loci that are transcribed and marked by H3K4me3 in all three rodents (I), in Mmus and Mcas but not in Rnor (II), in Mmus only (III), in Mcas only (IV) and Rnor only (V). Peaks were sorted according to their width. (C) Heatmap similar to (D) representing intergenic lncRNA transcripts anchored on predicted TSS (black: more than one RNAseq reads and white: less than one RNAseq reads). (D) Transcriptional turnover of liver-expressed protein coding (black) or intergenic lncRNA loci (red) in rodents.</p

Rodent conserved intergenic lncRNA loci and promoter sequences exhibit constraint.

<p>Normalised nucleotide substitution rates for (A) 160 intergenic lncRNA loci conserved in rodents (expressed in Mmus, Mcas and Rnor) and 108 <i>Mus</i> genus specific intergenic lncRNA loci; and (B) 159 putative intergenic lncRNA promoters conserved in rodents and 104 <i>Mus</i> genus specific intergenic lncRNA putative promoters. Putative proximal intergenic lncRNA promoters were defined as the 400 bp upstream region of the predicted TSS. Yellow dashed line represents the expected neutral substitution rate. Compared to neutral sequence (ancestral repeats, AR) in the vicinity, nucleotide substitution rates differ significantly for loci and promoter of intergenic lncRNA transcripts conserved in rodents (as indicated by asterisks ***, <i>p</i><0.001) and the promoters of <i>Mus</i> genus specific intergenic lncRNAs (***, <i>p</i><0.001).</p

Additional file 1: of Integrating data from randomized controlled trials and observational studies to predict the response to pregabalin in patients with painful diabetic peripheral neuropathy

Cluster analysis performance. (PDF 335 kb

1929-09-28

Supplementary figures. Supplementary document (.pdf) containing all Supplementary figures. (PDF 1165 kb

Additional file 1: of Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types

Supplementary figures. Supplementary document (.pdf) containing all Supplementary figures. (PDF 1165 kb