30 research outputs found

    Cognitive status.

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    <p>Depiction of average cognitive profiles for all subject cohorts assessed in this study.</p

    Cross-sectional results in the mid-sagittal corpus callosum.

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    <p>TBSS results across the sagittal midline for very mild and mild Alzheimer’s disease groups compared to controls.</p

    Cross-sectional study of very mild Alzheimer’s disease.

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    <p>TBSS results for the very mild Alzheimer’s disease group compared to controls. Statistical maps (thresholded at TFCE-P<0.05) for increased axial/radial diffusivity and reduced FA overlaid onto the mean FA skeleton and the MNI152 template. Coronal depths are given in millimetres.</p

    Demographic summary including cognitive features for Alzheimer’s disease patients and for a group of elderly controls.

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    <p>Disease severity (as measured by ACE-R) enabled a median split of the patient cohort into very mild and mild Alzheimer’s disease subgroups.</p><p>Where appropriate, group values are given as mean (SD).</p><p>MMSE/30 = Mini-mental state examination score out of 30-point total; ACE-R/100 = Addenbrooke’s cognitive examination-revised score out of 100-point total.</p><p>Wilcoxon rank-sum significance levels: *P<0.01 (Alzheimer’s disease worse than controls, two-tailed); **P<0.05 (Alzheimer’s disease worse than controls, two-tailed, Bonferroni-corrected on n = 28 tests); ∧P<0.05 (Mild worse than very mild Alzheimer’s disease, two-tailed, Bonferroni-corrected on n = 28).</p

    Longitudinal DTI assessment of Alzheimer's disease in the splenium.

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    <p>Baseline and 12 months versus controls comparisons are reported as Wilcoxon rank-sum Z-statistic values; paired longitudinal results are given as Wilcoxon signed-rank Z-statistic.</p><p>Significance levels: <sup>§</sup>0.01</p

    Corpus callosum subdivision.

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    <p>Depiction of the semi-automated callosal subdivision into splenium, truncus and genu (top), and their intersection with the mean FA skeleton inferred from N = 69 subjects–N = 43 Alzheimer’s disease patients and N = 26 matched controls (bottom).</p
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