First and Second Mover Advantage in Asymmetric Price Duopoly

We consider the issue of first versus second mover advantage in differentiated-product Bertrand duopoly with asymmetric linear costs. We provide a generalization of some well-known results in the cases where prices are strategic substitutes or complements, dispensing with extraneous assumptions of single-valued optimal reactions, uniqueness of Bertrand equilibrium, ... We also consider a new mixed case. Our approach is based on the theory of supermodular optimization/games. Furthermore, we show that even when prices are strategic complemnts, one firm may have a first mover advantage under a linear demand.

R&D spillovers, concentration and market performance

In a two-stage R&D game of process innovation, we investigate the effect of exogenously changing R&D spillovers and market concentration on the equilibrium level of effective cost reduction, total output, profits and social welfare. Interpreting spillover as a measure of patent protection, we find that weaker patent protection results in less R&D. We also show that firms prefer weaker patent protection, but social welfare is maximized for higher levels of patent protection. In terms of market concentration we show that firm profits decrease with increasing numbers of firms. Social welfare is typically maximized under oligopoly with the optimal number of firms depending on the level of spillover and efficiency of R&D investment

Threshold public good games and impulse balance theory

We propose and develop a model of behavior in threshold public good games. The model draws on learning direction theory and impulse balance theory. We find good support for the model and demonstrate that it can explain the success rates observed in threshold public good experiments. The model is applied in a variety of dierent settings : we compare games with a full refund to those with no refund, consider changes in relative endowment, and consider changes in the step return and net reward.Public good, threshold, learning direction theory, impulse balance theory, counterfactual thinking

Hormone-Mediated Gene-Specific Translation Regulation

The central role of translation regulation in the control of critical cellular processes has long been recognized. Yet the systematic exploration of quantitative changes in translation at a genome-wide scale in response to specific stimuli has only recently become technically feasible. Using a genetic approach, we have identified new Arabidopsis weak-ethylene insensitive mutants that also display defects in translation, which suggested the existence of a previously unknown molecular module involved in ethylene-mediated translation regulation of components of this signaling pathway. To explore this link in detail, we implemented for Arabidopsis the ribosome-footprinting technology, which enables the study of translation at a whole-genome level at single codon resolution[1]. Using ribosome-footprinting we examined the effects of short exposure to ethylene on the Arabidopsis translatome looking for ethylene-triggered changes in translation rates that could not be explained by changes in transcript levels. The results of this research, in combination with the characterization of a subset of the aforementioned weak-ethylene insensitive mutants that are defective in the UPF genes (core-components of the nonsense-mediated mRNA decay machinery), uncovered a translation-based branch of the ethylene signaling pathway[2]. In the presence of ethylene, translation of a negative regulator of ethylene signaling EBF2 is repressed, despite induced transcription of this gene. These translational effects of ethylene require the long 3´UTR of EBF2 (3´EBF2), which is recognized by the C-terminal end of the key ethylene-signaling protein EIN2 (EIN2C) in the cytoplasm once EIN2C is released from the ER-membrane by proteolytic cleavage. EIN2C binds the 3´EBF2, recruits the UPF proteins and moves to P-bodies, where the translation of EBF2 in inhibited despite its mRNA accumulation. Once the ethylene signal is withdrawn, the translation of the stored EBF2 mRNAs is resumed, thus rapidly dampening the ethylene response. These findings represent a mechanistic paradigm of gene-specific regulation of translation in response to a key growth regulator. Translation regulatory elements can be located in both 3′ and 5′ UTRs. We are now focusing on the ead1 and ead2 mutants, another set of ethylene-signaling mutants defective in translational regulation. Ribosome-footprinting on the ead1 mutant revealed an accumulation of translating ribosomes in the 5´UTRs of uORF-containing genes and reduction in the levels of ribosomes in the main ORF. The mutant is also impaired in the translation of GFP when this reporter is fused to WT 5´UTR of potential EAD1 targets but not when GFP is fused to the uORF-less versions of the same 5´UTRs. Our hypothesis is that EAD1/2 work as a complex that is required for the efficient translation of mRNAs that have common structural (complex 5´UTR with uORFs) and functional (regulation of key cellular processes) features. We are working towards the identification of the conditions where the EAD1 regulation of translation is required. [1] Ingolia, N. et al. (2009) Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling. Science, 324; 218-222 [2] Merchante, C. et al. (2015) Gene-Specific Translation Regulation Mediated by the Hormone-Signaling Molecule EIN2. Cell, 163(3): 684-697Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Efficiency in a forced contribution threshold public good game

We contrast and compare three ways of predicting efficiency in a forced contribution threshold public good game. The three alternatives are based on ordinal potential, quantal response and impulse balance theory. We report an experiment designed to test the respective predictions and find that impulse balance gives the best predictions. A simple expression detailing when enforced contributions result in high or low efficiency is provided

Effect of monovalent cations on the kinetics of hypoxic conformational change of mitochondrial complex I

AbstractMitochondrial complex I is a large, membrane-bound enzyme central to energy metabolism, and its dysfunction is implicated in cardiovascular and neurodegenerative diseases. An interesting feature of mammalian complex I is the so-called A/D transition, when the idle enzyme spontaneously converts from the active (A) to the de-active, dormant (D) form. The A/D transition plays an important role in tissue response to ischemia and rate of the conversion can be a crucial factor determining outcome of ischemia/reperfusion. Here, we describe the effects of alkali cations on the rate of the D-to-A transition to define whether A/D conversion may be regulated by sodium.At neutral pH (7–7.5) sodium resulted in a clear increase of rates of activation (D-to-A conversion) while other cations had minor effects. The stimulating effect of sodium in this pH range was not caused by an increase in ionic strength. EIPA, an inhibitor of Na+/H+ antiporters, decreased the rate of D-to-A conversion and sodium partially eliminated this effect of EIPA. At higher pH (>8.0), acceleration of the D-to-A conversion by sodium was abolished, and all tested cations decreased the rate of activation, probably due to the effect of ionic strength.The implications of this finding for the mechanism of complex I energy transduction and possible physiological importance of sodium stimulation of the D-to-A conversion at pathophysiological conditions in vivo are discussed

Ostracod species of the genus <em>Cytheropteron</em> from late Pleistocene-Holocene and recent sediments of the Laptev Sea (Arctic Siberia)

Sixteen species of the genus Cytheropteron from the Laptev Sea Late Pleistocene, Holocene deposits and Recent surface sediments have been described. Analysis of the literature on this subject and the collections of O.M.Lev from St. Petersburg, together with our own material from the Laptev Sea, allowed us to introduce certain changes in the taxonomy of this genus. One species Cytheropteron laptevensis Stepanova sp. nov. is described as new

Recent Ostracoda from the Laptev Sea (Arctic Siberia): Species assemblages and some environmental applications

Ostracod assemblages from coretop sediments collected at 26 localities at different depths of the Laptev Sea shelf and upper continental slope were investigated for assemblage studies. A total of 41 species belonging to 19 genera and 12 families have been identified. Three assemblages have been established that could be linked to environmental factors such as water depth, bottom salinities, water mass circulation and sea-ice transportation. The species-rich and abundant assemblages of the western and central Laptev Sea were related to the Atlantic waters occupying the upper continental slope. These include relatively deep-water forms that show clear affinities to North Atlantic and Arctic Ocean assemblages (Cytheropteron biconvexa, C. testudo, C. simplex, C. nodosoalatum, C. inflatum, C. porterae, Krithe glacialis, K. minima, Pseudocythere caudata, Polycope punctata, P. orbicularis). In the eastern middle shelf region, the assemblage is comprised of Acanthocythereis dunelmensis together with other normal marine species (Semicytherura complanata, Elofsonella concinna, Cluthia cluthae). This assemblage seems connected to the winter flaw polynya which is believed to be the main area of sediment entrainment into sea ice. The inner shelf assemblage of the southern Laptev Sea is dominated by shallow-water euryhaline species (Paracyprideis pseudopunctillata and Heterocyprideis sorbyana) with admixture of the brackish-water species Roundstonia macchesneyi. The unusual occurrence of a number of shallow-water ostracod species on the upper continental slope may be explained by ice-rafting which these ostracods are probably able to survive

The spillover effect of companies' brands in B2B relationships : the role of governance form choice

Masteroppgave(MSc) in Master of Science in Strategic Marketing Management - Handelshøyskolen BI, 2014In marketing literature there is a large gap in understanding the importance of brands and brand management in interorganizational relationships. This thesis aims to extend the existing B2B branding literature by analyzing the spillover effect of companies’ brands in interorganizational relationships. The current paper suggests that relational governance form should be positively related to brand spillover effect on both focal and partner companies. Additionally, this thesis is testing whether the relationship between reputation, resources and contracting capabilities with brand spillover effect is strengthened (weakened) while moderated by governance forms. These ideas are examined using a sample of 86 Ukrainian B2B managers. By means of hierarchical regression analyses it is found that (1) there is a significant positive relationship between relational governance form and the extent of spillover effect of brands in B2B relationship for partner firm; (2) the relationship between contracting capabilities and brand spill-over effect for partner firm is weakened while moderated by formal governance; (3) the direct relationship between reputation of a partner firm with brand spillover effect for a focal company is positive; and (4) positive relationship between reputation of a focal firm with brand spill-over effect for a partner company is strengthened while moderated by the relational governance form. Based on the results theoretical and managerial implications are provided

Teachers' use of students' first language in primary school English as a foreign language classroom : a study of Russian-language school in Estonia

This thesis is a study of teachers' use of students' mother tongue (Russian) in English-language classrooms in one Russian-language school in Estonia. The aim of the study is to find out the amount and functions of the mother tongue use by the teachers in the primary English as a foreign language classroom. In order to gain the data for the study, three primary classroom English language lessons were observed and analysed in detail using the word-count method and the functional analysis of the teachers' utterances. Lesson observations were followed by the semi-structured interviews with the teachers. The teachers' answers about their classroom practice were compared to the observation data. The Introduction of this study provides a brief insight into the topic of the role of the first language in foreign language teaching, presents the rationale for the research and gives an overview of the structure of the paper. The first chapter discusses the findings of the previous research concerning the amount and the main purposes for using the first language in the English as a foreign language classroom. The second chapter gives an overview of the participants, the data gathering methods and its analysis. The third chapter focuses on presenting and analysing the lesson observation data and the interviews with the teachers. The fourth chapter provides an evaluation of the research findings in the light of previous research. The Conclusion summarises the findings of the study.https://www.ester.ee/record=b5156590*es