Soluble Guanylate Cyclase Generation of cGMP Regulates Migration of MGE Neurons

Here we have provided evidence that nitric oxide-cyclic GMP (NO-cGMP) signaling regulates neurite length and migration of immature neurons derived from the medial ganglionic eminence (MGE). Dlx1/2(-/-) and Lhx6(-/-) mouse mutants, which exhibit MGE interneuron migration defects, have reduced expression of the gene encoding the alpha subunit of a soluble guanylate cyclase (Gucy1A3). Furthermore, Dlx1/2(-/-) mouse mutants have reduced expression of NO synthase 1 (NOS1). Gucy1A3(-/-) mice have a transient reduction in cortical interneuron number. Pharmacological inhibition of soluble guanylate cyclase and NOS activity rapidly induces neurite retraction of MGE cells in vitro and in slice culture and robustly inhibits cell migration from the MGE and caudal ganglionic eminence. We provide evidence that these cellular phenotypes are mediated by activation of the Rho signaling pathway and inhibition of myosin light chain phosphatase activity

The OPERA magnetic spectrometer

The OPERA neutrino oscillation experiment foresees the construction of two magnetized iron spectrometers located after the lead-nuclear emulsion targets. The magnet is made up of two vertical walls of rectangular cross section connected by return yokes. The particle trajectories are measured by high precision drift tubes located before and after the arms of the magnet. Moreover, the magnet steel is instrumented with Resistive Plate Chambers that ease pattern recognition and allow a calorimetric measurement of the hadronic showers. In this paper we review the construction of the spectrometers. In particular, we describe the results obtained from the magnet and RPC prototypes and the installation of the final apparatus at the Gran Sasso laboratories. We discuss the mechanical and magnetic properties of the steel and the techniques employed to calibrate the field in the bulk of the magnet. Moreover, results of the tests and issues concerning the mass production of the Resistive Plate Chambers are reported. Finally, the expected physics performance of the detector is described; estimates rely on numerical simulations and the outcome of the tests described above.Comment: 6 pages, 10 figures, presented at the 2003 IEEE-NSS conference, Portland, OR, USA, October 20-24, 200

Rho primes in analyzing e+e- annihilation, MARK III, LASS and ARGUS data

The results of an analysis are presented of some recent data on the reactions $e^+e^-\to\pi^+\pi^-\pi^+\pi^-$, $e^+e^-\to\pi^+\pi^-\pi^0\pi^0$ with the subtracted $\omega\pi^0$ events, $e^+e^-\to\omega\pi^0$, $e^+e^-\to\eta \pi^+\pi^-$, $e^+e^-\to\pi^+\pi^-$, $K^-p\to\pi^+\pi^-\Lambda$, the decays $J/\psi\to\pi^+\pi^-\pi^0$, $tau^-\to\nu_tau\pi^+\pi^-\pi^-\pi^0$ $tau^-\to\nu_\tau\omega\pi^-$, upon taking into account both the strong energy dependence of the partial widths on energy and the previously neglected mixing of the $\rho$ type resonances. The above effects are shown to exert an essential influence on the specific values of masses and coupling constants of heavy resonances and hence are necessary to be accounted for in establishing their true nature.Comment: 20 pages, ReVTeX, 9 Postscript figures As compared to hep-ph/9607398, new material concerning the analysis of the ARGUS data on the tau decays into four pion hadronic states is adde

Integrated three-dimensional models for noninvasive monitoring and valorization of the Morgantina silver treasure (Sicily)

The Morgantina silver treasure belonging to the Archaeological Museum of Aidone (Sicily) was involved in a three-dimensional (3-D) survey and diagnostics campaign for monitoring the collection over time in anticipation of their temporary transfer to the Metropolitan Museum of Art in New York for a period of 4 years. Using a multidisciplinary approach, a scientific and methodological protocol based on noninvasive techniques to achieve a complete and integrated knowledge of the precious items and their conservation state, as well as to increase their valorization, has been developed. All acquired data, i.e., 3-D models, ultraviolet fluorescence, x-ray images, and chemical information, will be made available, in an integrated way, within a web-oriented platform, which will present an in-progress tool to deepen existing archaeological knowledge and production technologies and to obtain referenced information of the conservation state before and after moving of the collection from its exposure site

Electromagnetic form factors in the J/\psi mass region: The case in favor of additional resonances

Using the results of our recent analysis of e^+e^- annihilation, we plot the curves for the diagonal and transition form factors of light hadrons in the time-like region up to the production threshold of an open charm quantum number. The comparison with existing data on the decays of J/\psi into such hadrons shows that some new resonance structures may be present in the mass range between 2 GeVand the J/\psi mass. Searching them may help in a better understanding of the mass spectrum in both the simple and a more sophisticated quark models, and in revealing the details of the three-gluon mechanism of the OZI rule breaking in K\bar K channel.Comment: Formulas are added, typo is corrected, the text is rearranged. Replaced to match the version accepted in Phys Rev

The NESSiE way to searches for sterile neutrinos at FNAL

AbstractNeutrino physics is nowadays receiving more and more attention as a possible source of information for the long–standing problem of new physics beyond the Standard Model. The recent measurement of the mixing angle θ13 in the standard mixing oscillation scenario encourages us to pursue the still missing results on leptonic CP violation and absolute neutrino masses. However, puzzling measurements exist that deserve an exhaustive evaluation.The NESSiE Collaboration has been setup to undertake conclusive experiments to clarify the muon–neutrino disappearance measurements at small L/E, which will be able to put severe constraints to models with more than the three-standard neutrinos, or even to robustly measure the presence of a new kind of neutrino oscillation for the first time. To this aim the use of the current FNAL–Booster neutrino beam for a Short–Baseline experiment has been carefully evaluated. Its recent proposal refers to the use of magnetic spectrometers at two different sites, Near and Far ones. Their positions have been extensively studied, together with the possible performances of two OPERA–like spectrometers. The proposal is constrained by availability of existing hardware and a time–schedule compatible with the undergoing project of a multi–site Liquid–Argon detectors at FNAL.The experiment to be possibly setup at Booster will allow to definitively clarify the current νμ disappearance tension with νe appearance and disappearance at the eV mass scale

Prospects for the measurement of muon-neutrino disappearance at the FNAL-Booster

Neutrino physics is nowadays receiving more and more attention as a possible source of information for the long-standing problem of new physics beyond the Standard Model. The recent measurement of the mixing angle $\theta_{13}$ in the standard mixing oscillation scenario encourages us to pursue the still missing results on leptonic CP violation and absolute neutrino masses. However, puzzling measurements exist that deserve an exhaustive evaluation. The NESSiE Collaboration has been setup to undertake conclusive experiments to clarify the muon-neutrino disappearance measurements at small $L/E$, which will be able to put severe constraints to models with more than the three-standard neutrinos, or even to robustly measure the presence of a new kind of neutrino oscillation for the first time. To this aim the use of the current FNAL-Booster neutrino beam for a Short-Baseline experiment has been carefully evaluated. This proposal refers to the use of magnetic spectrometers at two different sites, Near and Far. Their positions have been extensively studied, together with the possible performances of two OPERA-like spectrometers. The proposal is constrained by availability of existing hardware and a time-schedule compatible with the CERN project for a new more performant neutrino beam, which will nicely extend the physics results achievable at the Booster. The possible FNAL experiment will allow to clarify the current $\nu_{\mu}$ disappearance tension with $\nu_e$ appearance and disappearance at the eV mass scale. Instead, a new CERN neutrino beam would allow a further span in the parameter space together with a refined control of systematics and, more relevant, the measurement of the antineutrino sector, by upgrading the spectrometer with detectors currently under R&D study.Comment: 76 pages, 52 figure

Prospect for Charge Current Neutrino Interactions Measurements at the CERN-PS

Tensions in several phenomenological models grew with experimental results on neutrino/antineutrino oscillations at Short-Baseline (SBL) and with the recent, carefully recomputed, antineutrino fluxes from nuclear reactors. At a refurbished SBL CERN-PS facility an experiment aimed to address the open issues has been proposed [1], based on the technology of imaging in ultra-pure cryogenic Liquid Argon (LAr). Motivated by this scenario a detailed study of the physics case was performed. We tackled specific physics models and we optimized the neutrino beam through a full simulation. Experimental aspects not fully covered by the LAr detection, i.e. the measurements of the lepton charge on event-by-event basis and their energy over a wide range, were also investigated. Indeed the muon leptons from Charged Current (CC) (anti-)neutrino interactions play an important role in disentangling different phenomenological scenarios provided their charge state is determined. Also, the study of muon appearance/disappearance can benefit of the large statistics of CC muon events from the primary neutrino beam. Results of our study are reported in detail in this proposal. We aim to design, construct and install two Spectrometers at "NEAR" and "FAR" sites of the SBL CERN-PS, compatible with the already proposed LAr detectors. Profiting of the large mass of the two Spectrometers their stand-alone performances have also been exploited.Comment: 70 pages, 38 figures. Proposal submitted to SPS-C, CER