Univariate and multivariate Cox proportional hazards model for 5-year cancer-specific survival (N = 634 [147 events, 487 censored]).

Univariate and multivariate Cox proportional hazards model for 5-year cancer-specific survival (N = 634 [147 events, 487 censored]).</p

Kaplan-Meier survival curves for the independent variables.

<p>Kaplan-Meier survival curves for the independent variables.</p

Comparison between those included and those excluded in the analysis.

<p>Comparison between those included and those excluded in the analysis.</p

Pretreatment patient characteristics of newly diagnosed head and neck cancer patients.

<p>(N = 622).</p

Univariate and multivariate Cox proportional hazards model for 5-year disease-free survival (N = 634 [207 events, 427 censored]).

<p>Univariate and multivariate Cox proportional hazards model for 5-year disease-free survival (N = 634 [207 events, 427 censored]).</p

Univariate and multivariate Cox proportional hazards model for 5-year overall survival.

<p>(N = 634 [216 events, 418 censored]).</p

DNA methylation heatmap constructed using unsupervised hierarchical Ward clustering of the 711 CpG sites with the greatest variance across the 68 tumor samples identified six distinct methylation clusters.

<p>DNA methylation heatmap constructed using unsupervised hierarchical Ward clustering of the 711 CpG sites with the greatest variance across the 68 tumor samples identified six distinct methylation clusters.</p

Kaplan-Meier survival curves depicting three year survival for each of the six clusters identified via unsupervised hierarchical cluster analysis.

<p>Kaplan-Meier survival curves depicting three year survival for each of the six clusters identified via unsupervised hierarchical cluster analysis.</p

CpG sites with DNA methylation values significantly associated (Adjusted p<0.05) with HPV status of the tumor.

<p>Positive T-Values correspond with higher methylation in HPV(+) while negative T-Values correspond with higher methylation in HPV(−) tumors.</p

Clinical characteristics of the study participants (n = 68).

<p>Clinical characteristics of the study participants (n = 68).</p