DataSheet1_Screening and diagnosis of triple negative breast cancer based on rapid metabolic fingerprinting by conductive polymer spray ionization mass spectrometry and machine learning.pdf

We present the use of conductive spray polymer ionization mass spectrometry (CPSI-MS) combined with machine learning (ML) to rapidly gain the metabolic fingerprint from 1 μl liquid extraction from the biopsied tissue of triple-negative breast cancer (TNBC) in China. The 76 discriminative metabolite markers are verified at the primary carcinoma site and can also be successfully tracked in the serum. The Lasso classifier featured with 15- and 22-metabolites detected by CPSI-MS achieve a sensitivity of 88.8% for rapid serum screening and a specificity of 91.1% for tissue diagnosis, respectively. Finally, the expression levels of their corresponding upstream enzymes and transporters have been initially confirmed. In general, CPSI-MS/ML serves as a cost-effective tool for the rapid screening, diagnosis, and precise characterization for the TNBC metabolism reprogramming in the clinical practice.</p

Organogold Clusters Protected by Phenylacetylene

A new class of monolayer-protected Au clusters with Au–C covalent bonds (organogold clusters) was synthesized by ligating phenylacetylene (PhCCH) to PVP-stabilized Au clusters. Matrix-assisted laser desorption ionization mass spectrometry revealed for the first time a series of stable compositions of the organogold (Au:C2Ph) clusters

Aerobic Oxidation of Cyclohexane Catalyzed by Size-Controlled Au Clusters on Hydroxyapatite: Size Effect in the Sub-2 nm Regime

In this work, we synthesized gold clusters, Aun (n = 10, 18, 25, 39), with atomically controlled sizes on hydroxyapatite (HAP) and studied the catalysis for aerobic oxidation of cyclohexane. These Aun/HAP catalysts could efficiently oxidize cyclohexane to cyclohexanol and cyclohexanone. The turnover frequency monotonically increased with an increase in the size, reaching values as high as 18 500 h−1 Au atom−1 at n = 39, and thereafter decreased with a further increase in n up to n ∼ 85. This finding provides a fundamental insight into size-specific catalysis of gold in the cluster regime (diameter < 2 nm) and a guiding principle for rational design of Au cluster-based catalysts

Enhancement in Aerobic Alcohol Oxidation Catalysis of Au₂₅ Clusters by Single Pd Atom Doping

Au₂₅ and Pd₁Au₂₄ clusters on multiwalled carbon nanotubes were developed via adsorption of Au₂₅(SC₁₂H₂₅)₁₈ and Pd₁Au₂₄(SC₁₂H₂₅)₁₈, respectively, on the nanotubes, followed by calcination. Comparison of their catalysis for the aerobic oxidation of benzyl alcohol showed that single Pd atom doping significantly improved the catalytic performance of Au₂₅ for the first time

Preparation of Zeolite ANA Crystal from Zeolite Y by in Situ Solid Phase Iso-Structure Transformation

A new method has been explored to synthesize zeolite ANA crystals with regular icositetrahedron in aqueous media via transformation of zeolite Y under the conditions of low temperature, short reaction time, and without organic template. The products are perfect, almost 100% crystals. The samples prepared at different crystallization stages are measured by XRD, TEM, and SEM to investigate the transformation mechanism from zeolite Y to zeolite ANA. It has been demonstrated for the first time that the mechanism of forming a zeolite ANA polycrystal with sphere or shell morphologies is the in situ solid phase iso-structure transformation (Is-SPIST) of zeolite Y. The Is-SPIST mechanism is also supported by the results of steam-induced crystallization experiments and other assistant means, including the same Si/Al ratio, the same weight, the same particle size, and the same morphology before and after transformation of zeolite Y to zeolite ANA. It is also observed that a spherical or shell ANA polycrystal is constructed via the reconstruction from its exterior to interior, to form an ANA single crystal with a solid or hollow icositetrahedron. The main driving force of the reconstruction is considered to be the grain boundary energy existing between polycrystalline grains. This process also obeys the mechanism of in situ solid phase reconstruction (Is-SPR). Furthermore, the size and morphology of the zeolite ANA single crystal can be modified by surfactants

Iron-Assisted Vapor-Phase Hydrothermal Method: A Low-Temperature Approach To Synthesize Blue Light Emissive SiO<i>_x</i> Nanowires with Single-Crystal Structure of <i>P</i>2₁2₁2

A novel and facile approach, named iron-assisted vapor-phase hydrothermal method, is proposed to fabricate the long and stable bright blue light emitting SiOx nanowires (SiONWs) at a low temperature. The obtained SiONWs possess a brand-new single-crystalline structure of space group P21212. This new type of bright blue light emitting SiONW with a new single-crystalline structure may initiate a new 1D optical material and offer new opportunities for the research in science and technology

Palladium Nanoparticles Confined in the Cages of MIL-101: An Efficient Catalyst for the One-Pot Indole Synthesis in Water

A hydrothermally stable metal–organic framework, MIL-101, was used as support for a metallic Pd nanoparticle catalyst. With the characterization of X-ray photoelectron spectroscopy, X-ray diffraction, N2 physisorption, scanning electron microscopy, transmission electron microscopy, and CO chemisorption, the resulting Pd nanoparticles were identified to be confined in the cages of MIL-101. During the one-pot indole synthesis between 2-iodoaniline and phenylacetylene in water, the as-prepared Pd catalyst was more active and stable than the metallic Pd nanoparticles supported on MCM-41. The enhanced catalytic properties were found to depend on both the texture and the surface chemistry of the MIL-101 support

Ordered Mesoporous Ni Nanowires with Enhanced Hydrogenation Activity Prepared by Electroless Plating on Functionalized SBA-15

Highly ordered mesoporous Ni nanowires were synthesized by Ni electroless plating on the amine-functionalized SBA-15 (NH2−SBA-15) support, followed by removing the silica template with NaOH. The incorporation of amine groups into the pore channels and the subsequent activation of NH2−SBA-15 with PdCl2 acetone solution are essential for generating Pd crystal seeds distributed in the pore channels. As a result, the following Ni electroless plating occurred mainly in pore channels, leading to the formation of ordered Ni nanowires catalyst with high surface area, ordered mesopore arrangement, and higher activity than Raney Ni in liquid-phase p-chloronitrobenzene hydrogenation

Iron-Assisted Vapor-Phase Hydrothermal Method: A Low-Temperature Approach to Synthesize Blue Light Emissive SiO<i>_x</i> Nanowires with Single-Crystal Structure of <i>P</i>2₁2₁2 [<i>J. Am. Chem. Soc.</i> <b>2006</b>, <i>128</i>, 1470−1471].

Iron-Assisted Vapor-Phase Hydrothermal Method:  A Low-Temperature Approach to Synthesize Blue Light Emissive SiOx Nanowires with Single-Crystal Structure of P21212 [J. Am. Chem. Soc. 2006, 128, 1470−1471]