Enterprise Risk Management Best Practices for Improvement Financial Performance in Manufacturing SMEs in Cameroon

The aim of this study is to determine the relationship between the best practices and the financial performance among 86 manufacturing small and medium enterprises in Cameroon. To achieve this objective, we will carry out a Multivariate Analysis; and the results based on correlation analysis highlight a positive and significant impact of risk culture on financial performance of these enterprises and also show that the independence of the board of directors by itself is not sufficient to increase the firm’s performance

Antifibrotic effects of crocetin in scleroderma fibroblasts and in bleomycin-induced sclerotic mice

OBJECTIVE: To investigate the antifibrotic effects of crocetin in scleroderma fibroblasts and in sclerotic mice. METHODS: Skin fibroblasts that were isolated from three systemic scleroderma (SSc) patients and three healthy subjects were treated with crocetin (0.1, 1 or 10 μM). Cell proliferation was measured with an MTT assay. Alpha-smooth muscle actin was detected via an immunohistochemical method. Alpha 1 (I) procollagen (COL1A1), alpha 1 (III) procollagen (COL3A1), matrix metalloproteinase (MMP)-1 and tissue inhibitor of matrix metalloproteinase (TIMP)-1 mRNA levels were measured using real-time PCR. SSc mice were established by the subcutaneous injection of bleomycin. Crocetin (50 mg/kg/d) was injected intraperitoneally for 14 days. Dermal thickness and lung fibrosis were assessed with Masson's trichrome staining. Plasma ET-1 was detected with an enzyme-linked immunosorbent assay (ELISA). Skin and lung ET-1 and COL1A1 mRNA levels were measured via real-time PCR. RESULTS: Crocetin inhibited the proliferation of SSc and normal fibroblasts, an effect that increased with crocetin concentration and incubation time. Crocetin decreased the expression of α-SMA and the levels of mRNA for COL1A1, COL3A1 and matrix metalloproteinase-1, while crocetin increased TIMP-1 mRNA levels in both SSc and normal fibroblasts. Skin and lung fibrosis was induced, and the levels of ET-1 in the plasma, skin and lungs were elevated in bleomycin-injected mice. Crocetin alleviated the thickening of the dermis and lung fibrosis; decreased COL1A1 mRNA levels in the skin and lung; and simultaneously decreased ET-1 concentrations in the plasma and ET-1 mRNA levels in the skin and lungs of the bleomycin-induced sclerotic mice, especially during the early phase (weeks 1-3). CONCLUSION: Crocetin inhibits cell proliferation, differentiation and collagen production in SSc fibroblasts. Crocetin alleviates skin and lung fibrosis in a bleomycin-induced SSc mouse model, in part due to a reduction in ET-1

BIOMECHANICAL ANALYSIS OF THE PADDLING TECHNIQUE AND THE VELOCITY OF 1000M FULL PADDLING EVENT: A CASE STUDY.

Biomechanical analysis from data obtained by video camera was used to investigate the paddling technique and the velocity of 1000m full paddling event. The results showed the characteristics and the advantages of Meng’s paddling technique. The data also revealed deficiencies and provided a set of kinematics parameters for evaluation, diagnosis and training of paddling techniques

Effectiveness of On-the-job Learning for Enterprises' Innovativeness

The mode of on-the-job learning – one of the methods of acquiring competencies still remains one of the main modes of acquiring workplace competencies in conventional industries in developing countries. This paper explores the impact of aforesaid mode of competency acquisition for enterprise innovativeness of an industry of Sri Lanka.  A structured questionnaire was used to gather primary data related to modes of acquiring competencies. Before data collection, it was reviewed by industry experts and piloted later on for validity. The paper analyses and presents the effectiveness of on-the-job learning on the innovativeness of enterprises in this industry.  The research has found that the main mode of acquiring enterprise competencies remains on-the-job learning. It has been found that the level of innovations in enterprises in the industry remains at low attributed to the traditional way of acquiring competencies. As a result, the industry stagnates and faces challenges for sustainability.  No similar research study was done before in this industry and this is an original work. The study has implications to policy, theoretical and practical aspects of the industry

Two Sides of the Same Coin: White-box and Black-box Attacks for Transfer Learning

Transfer learning has become a common practice for training deep learning models with limited labeled data in a target domain. On the other hand, deep models are vulnerable to adversarial attacks. Though transfer learning has been widely applied, its effect on model robustness is unclear. To figure out this problem, we conduct extensive empirical evaluations to show that fine-tuning effectively enhances model robustness under white-box FGSM attacks. We also propose a black-box attack method for transfer learning models which attacks the target model with the adversarial examples produced by its source model. To systematically measure the effect of both white-box and black-box attacks, we propose a new metric to evaluate how transferable are the adversarial examples produced by a source model to a target model. Empirical results show that the adversarial examples are more transferable when fine-tuning is used than they are when the two networks are trained independently

Influences of Divalent Ions in Natural Seawater/River Water on Nanofluidic Osmotic Energy Generation

Besides the dominant NaCl, natural seawater/river water contains trace multivalent ions, which can provide effective screening to surface charges. Here, in both negatively and positively charged nanopores, influences from divalent ions as counterions and coions have been investigated on the performance of osmotic energy conversion (OEC) under natural salt gradients. As counterions, trace Ca2+ ions can suppress the electric power and conversion efficiency significantly. The reduced OEC performance is due to the bivalence and low diffusion coefficient of Ca2 ions, instead of the uphill transport of divalent ions discovered in the previous work. Effectively screened charged surfaces by Ca2+ ions induce enhanced diffusion of Cl ions which simultaneously decreases the net ion penetration and ionic selectivity of the nanopore. While as coions, Ca2+ ions have weak effects on the OEC performance. The promotion from charged exterior surfaces on OEC processes for ultra-short nanopores is also studied, which effective region is ~200 nm in width beyond pore boundaries independent of the presence of Ca2+ ions. Our results shed light on the physical details of the nanofluidic OEC process under natural seawater/river water conditions, which can provide a useful guide for high-performance osmotic energy harvesting.Comment: 24 pages, 5 figure

Radiofrequency ablation with or without transarterial chemoembolization for hepatocellular carcinoma meeting Milan criteria: a focus on tumor progression and recurrence patterns

Background/objectiveThe aim of this study was to evaluate tumor progression and recurrence patterns of radiofrequency ablation (RFA) with or without transarterial chemoembolization (TACE) for treating hepatocellular carcinoma (HCC) that meets Milan criteria.MethodsThis retrospective study included consecutive HCC patients meeting Milan criteria who underwent percutaneous RFA with or without TACE as initial treatment at a tertiary academic center between December 2017 and 2022. Technical success rate, local recurrence-free survival (LRFS), progression-free survival (PFS) and recurrence patterns were recorded.ResultsA total of 135 HCC patients (109 male [80.7%]) with a mean age of 62 years and 147 target lesions were retrospectively enrolled. The technical success rate was 99.3%. The median LRFS was 60 months, and the cumulative 1-, 3-, and 5-year LRFS were 88.9%, 70.1%, and 30.0%, respectively. Additionally, the median PFS was 23 months, with cumulative 1-, 3-, and 5-year PFS of 74%, 30%, and 0%, respectively. Multivariate analysis confirmed that age > 60, alpha-fetoprotein (AFP) (> 10), and albumin were associated with PFS (2.34, p = 0.004; 1.96, p = 0.021; 0.94, p = 0.007, respectively). Six recurrence patterns were identified: local tumor progression (LTP) alone (n = 15, 25.0%), intrahepatic distant recurrence (IDR) alone (n = 34, 56.7%), extrahepatic recurrence (ER) alone (n = 2, 3.3%), IDR + ER (n = 2, 3.3%), LTP + IDR (n = 5, 8.8%), and LTP + IDR + ER (n = 2, 3.3%). IDR occurred most frequently as a sign of good local treatment.ConclusionsRFA in combination with TACE does not appear to provide an advantage over RFA alone in improving tumor progression in patients with HCC meeting the Milan criteria. However, further prospective studies are needed to confirm these findings and to determine the optimal treatment approach for this patient population