47 research outputs found

    A Multicomponent Intervention Helped Reducing Sugar-Sweetened Beverage Intake in Economically Disadvantaged Hispanic Children

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    This study aimed to examine the effect of a multicomponent intervention program on consumption of sugar-sweetened beverages (SSBs), and lifestyle factors associated with SSB intake, in Hispanic children from low-income families

    Specialized Re-Ranking: A Novel Retrieval-Verification Framework for Cloth Changing Person Re-Identification

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    Cloth changing person re-identification(Re-ID) can work under more complicated scenarios with higher security than normal Re-ID and biometric techniques and is therefore extremely valuable in applications. Meanwhile, higher flexibility in appearance always leads to more similar-looking confusing images, which is the weakness of the widely used retrieval methods. In this work, we shed light on how to handle these similar images. Specifically, we propose a novel retrieval-verification framework. Given an image, the retrieval module can search for similar images quickly. Our proposed verification network will then compare the input image and the candidate images by contrasting those local details and give a similarity score. An innovative ranking strategy is also introduced to take a good balance between retrieval and verification results. Comprehensive experiments are conducted to show the effectiveness of our framework and its capability in improving the state-of-the-art methods remarkably on both synthetic and realistic datasets.Comment: Accepted by Pattern Recognitio

    Synthetic Datasets for Autonomous Driving: A Survey

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    Autonomous driving techniques have been flourishing in recent years while thirsting for huge amounts of high-quality data. However, it is difficult for real-world datasets to keep up with the pace of changing requirements due to their expensive and time-consuming experimental and labeling costs. Therefore, more and more researchers are turning to synthetic datasets to easily generate rich and changeable data as an effective complement to the real world and to improve the performance of algorithms. In this paper, we summarize the evolution of synthetic dataset generation methods and review the work to date in synthetic datasets related to single and multi-task categories for to autonomous driving study. We also discuss the role that synthetic dataset plays the evaluation, gap test, and positive effect in autonomous driving related algorithm testing, especially on trustworthiness and safety aspects. Finally, we discuss general trends and possible development directions. To the best of our knowledge, this is the first survey focusing on the application of synthetic datasets in autonomous driving. This survey also raises awareness of the problems of real-world deployment of autonomous driving technology and provides researchers with a possible solution.Comment: 19 pages, 5 figure

    High-speed widefield photoacoustic microscopy of small-animal hemodynamics

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    Optical-resolution photoacoustic microscopy (OR-PAM) has become a popular tool in small-animal hemodynamic studies. However, previous OR-PAM techniques variously lacked a high imaging speed and/or a large field of view, impeding the study of highly dynamic physiologic and pathophysiologic processes over a large region of interest. Here we report a high-speed OR-PAM system with an ultra-wide field of view, enabled by an innovative water-immersible hexagon-mirror scanner. By driving the hexagon-mirror scanner with a high-precision DC motor, the new OR-PAM has achieved a cross-sectional frame rate of 900 Hz over a 12-mm scanning range, which is 3900 times faster than our previous motor-scanner-based system and 10 times faster than the MEMS-scanner-based system. Using this hexagon-scanner-based OR-PAM system, we have imaged epinephrine-induced vasoconstriction in the whole mouse ear and vascular reperfusion after ischemic stroke in the mouse cortex in vivo, with a high spatial resolution and high volumetric imaging speed. We expect that the hexagon-scanner-based OR-PAM system will become a powerful tool for small animal imaging where the hemodynamic responses over a large field of view are of interest

    Assessing civility at an academic health science center: Implications for employee satisfaction and well-being.

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    Incivilities are pervasive among workers in healthcare institutions. Previously identified effects include deterioration of employee physical and mental health, absenteeism, burnout, and turnover, as well as reduced patient safety and quality of care. This study documented factors related to organizational civility at an academic health sciences center (AHSC) as the basis for future intervention work. We used a cross-sectional research design to conduct an online survey at four of five campuses of an AHSC. Using the Organizational Civility Scale (OCS), we assessed differences across gender, race (White and non-White) and job type (faculty or staff) in the eleven subscales (frequency of incivility, perceptions of organizational climate, existence of civility resources, importance of civility resources, feelings about current employment, employee satisfaction, sources of stress, coping strategies, overall levels of stress/coping ability, and overall civility rating). Significant gender differences were found in six of the eleven subscales: perception of organizational climate (p \u3c .001), existence of civility resources (p = .001), importance of civility resources (p \u3c .001), frequency of incivilities (p \u3c .001), employee satisfaction (p = .002), and overall civility rating (p = .007). Significant differences between respondents by self-identified race were found only in one subscale: existence of civility resources (p = .048). Significant differences were found between faculty and staff in four subscales: perception of organizational climate (p = .001), importance of civility resources (p = .02), employee satisfaction (p = .01), and overall levels of stress (p = .03). Results suggest that gender and employment type differences exist in the perception of organizational climate at the academic health center, while significant racial differences only occurred in reference to reported existence of civility resources. Attention to these differences should be incorporated into the development of programs to address the problem

    High-speed widefield photoacoustic microscopy of small-animal hemodynamics

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    Optical-resolution photoacoustic microscopy (OR-PAM) has become a popular tool in small-animal hemodynamic studies. However, previous OR-PAM techniques variously lacked a high imaging speed and/or a large field of view, impeding the study of highly dynamic physiologic and pathophysiologic processes over a large region of interest. Here we report a high-speed OR-PAM system with an ultra-wide field of view, enabled by an innovative water-immersible hexagon-mirror scanner. By driving the hexagon-mirror scanner with a high-precision DC motor, the new OR-PAM has achieved a cross-sectional frame rate of 900 Hz over a 12-mm scanning range, which is 3900 times faster than our previous motor-scanner-based system and 10 times faster than the MEMS-scanner-based system. Using this hexagon-scanner-based OR-PAM system, we have imaged epinephrine-induced vasoconstriction in the whole mouse ear and vascular reperfusion after ischemic stroke in the mouse cortex in vivo, with a high spatial resolution and high volumetric imaging speed. We expect that the hexagon-scanner-based OR-PAM system will become a powerful tool for small animal imaging where the hemodynamic responses over a large field of view are of interest

    The Interaction of Equol and Genistein on Estrogen Dependent Tumors and Bones in Ovariectomized Athymic Nude Mice

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    104 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008.Experiments were conducted to evaluate the possible effects of dietary equol, one of the metabolites of daidzein, with and without genistein on human estrogen dependent tumor growth and bone development in ovariectomized athymic nude mice. In the first study, the experiments were conducted to evaluate the effect of equol alone on the T47D human breast cancer cells and bone metabolism. At the physiological concentration levels, 100 nM equol stimulated the T47D cell proliferation similarly as 0.1 nM 17-beta-estradiol in vitro. However, 250 ppm and 750 ppm dietary equol, which gave the total plasma equol concentrations (95% CI) 2.24+/-1.0 muM and 6.84+/-2.41 muM respectively, didn't affect either the tumor growth or bone metabolism compared with placebo control diet in OVX athymic mice. Then the interaction between equol and genistein was evaluated using MCF-7 human breast cancer cells. Equol and genistein both stimulated MCF-7 cell proliferation at physiological concentration levels (10-8--10-5 muM) in vitro. The diets containing 500 ppm genistein, 500 ppm genistein plus 250 ppm equol, 500 ppm genistein plus 500 ppm equol and 500 ppm genistein plus 1000 ppm equol stimulated MCF-7 tumor growth in OVX athymic mice similarly during 18 weeks treatment. There was no significant difference (p >0.1) on the final tumor size and mammary terminal end buds number for the treatment groups. To explain the lack of activity for equol in vivo, two pharmacokinetic studies on equol and equol plus genistein were conducted. No interaction between equol and genistein on their absorption and elimination was found. The half-life times of plasma total equol and total genistein (both conjugate and aglycone forms) were 1.18+/-0.24 hours (mean +/- STD) and 1.57+/-0.16 hours (mean +/- STD), respectively. The average aglycone forms of equol and genistein at 0.5h, 1h, 2h and 4h were approximately 0.5% and 5.6% of their total concentration, respectively. The half-life time for genistein aglycone was 3.66 hours, which was more than double of EQ aglycone (1.44 hours). Low concentration and short half-life time of equol aglycone form caused low activity of equol in vivo. The last part of my study was focus on using mathematical modeling to simulate the tumor growth and classify the characteristics of the tumors stimulated by genistein and genistein plus equol. Approximately, 66% of the growing tumors, which had at least one fold increase than their initial tumor size, would have two growing phase. The average time for tumors treated with genistein entering the late exponential growing phase was slightly shorter than genistein plus equol treated ones (18.20+/-4.04 vs. 21.28+/-4.70, p=0.0529). Most of the tumors with the second growth phase would have lower response to estrogen than the original MCF-7 cells. Also, these tumors with increased response to genistein and equol had correlated decreased response to tamoxifen. This suggested that genistein or genistein plus equol may induce the estrogen dependent tumor to be estrogen independent through some pathways other than estrogen regulated ones. Future studies on these genistein or isoflavones regulated pathways may help us understand the association between diet factors and estrogen independent tumors.U of I OnlyRestricted to the U of I community idenfinitely during batch ingest of legacy ETD

    The Recent Development of Multifunctional Gold Nanoclusters in Tumor Theranostic and Combination Therapy

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    The rising incidence and severity of malignant tumors threaten human life and health, and the current lagged diagnosis and single treatment in clinical practice are inadequate for tumor management. Gold nanoclusters (AuNCs) are nanomaterials with small dimensions (≤3 nm) and few atoms exhibiting unique optoelectronic and physicochemical characteristics, such as fluorescence, photothermal effects, radiosensitization, and biocompatibility. Here, the three primary functions that AuNCs play in practical applications, imaging agents, drug transporters, and therapeutic nanosystems, are characterized. Additionally, the promise and remaining limitations of AuNCs for tumor theranostic and combination therapy are discussed. Finally, it is anticipated that the information presented herein will serve as a supply for researchers in this area, leading to new discoveries and ultimately a more widespread use of AuNCs in pharmaceuticals

    Genetic transformation of marine cyanobacterium Synechococcus sp CC9311 (Cyanophyceae) by electroporation

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    Synechococcus sp. CC9311 is a marine cyanobacterium characterized by type IV chromatic acclimation (CA). A genetic transformation system was developed as a first step to elucidate the molecular mechanism of CA. The results show that Synechococcus sp. CC9311 cells were sensitive to four commonly used antibiotics: ampicillin, kanamycin, spectinomycin, and chloramphenicol. An integrative plasmid to disrupt the putative phycoerythrin lyase gene mpeV, using a kanamycin resistance gene as selectable marker, was constructed by recombinant polymerase chain reaction. The plasmid was then transformed into Synechococcus sp. CC9311 via electroporation. High transformation efficiency was achieved at a field strength of 2 kV/cm. DNA analysis showed that mpeV was fully disrupted following challenge of the transformants with a high concentration of kanamycin. In addition, the transformants that displayed poor growth on agar SN medium could be successfully plated on agarose SN medium.Synechococcus sp. CC9311 is a marine cyanobacterium characterized by type IV chromatic acclimation (CA). A genetic transformation system was developed as a first step to elucidate the molecular mechanism of CA. The results show that Synechococcus sp. CC9311 cells were sensitive to four commonly used antibiotics: ampicillin, kanamycin, spectinomycin, and chloramphenicol. An integrative plasmid to disrupt the putative phycoerythrin lyase gene mpeV, using a kanamycin resistance gene as selectable marker, was constructed by recombinant polymerase chain reaction. The plasmid was then transformed into Synechococcus sp. CC9311 via electroporation. High transformation efficiency was achieved at a field strength of 2 kV/cm. DNA analysis showed that mpeV was fully disrupted following challenge of the transformants with a high concentration of kanamycin. In addition, the transformants that displayed poor growth on agar SN medium could be successfully plated on agarose SN medium
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