The Solar Neutrino Day/Night Effect in Super-Kamiokande

The time variation of the elastic scattering rate of solar neutrinos with electrons in Super-Kamiokande-I was fit to the day/night variations expected from active two-neutrino oscillations in the Large Mixing Angle region. Combining Super-Kamiokande measurements with other solar and reactor neutrino data, the mixing angle is determined as sin^2theta=0.276+0.033-0.026 and the mass squared difference between the two neutrino mass eigenstates as Delta m^2=7.1+0.6-0.5x10^-5eV^2. For the best fit parameters, a day/night asymmetry of -1.7+-1.6(stat)+1.3-1.2(syst)% was determined from the Super-Kamiokande data, which has improved statistical precision over previous measurements and is in excellent agreement with the expected value of -1.6%.Comment: 3 pages, 4 figures; to appear in the proceedings of the TAUP 2003 conferenc

Coincidence-based reconstruction for reactor antineutrino detection in gadolinium-doped Cherenkov detectors

A reconstruction algorithm has been developed to capitalize on advances in Cherenkov technology for reactor antineutrino detection. Large gadolinium-doped water (Gd-H$_2$O) Cherenkov detectors are a developing technology which use Gd loading to increase the visibility of the neutrons produced in inverse beta decay (IBD) interactions, which produce positron-neutron pairs coincident in time and space. In this paper, we describe the reconstruction which uses the combined light from both events in an IBD pair to accurately reconstruct the interaction vertex. The algorithm has been applied to the reconstruction of reactor antineutrinos in Gd-H$_2$O and in Gd-doped water-based liquid scintillator (Gd-WbLS), an advanced detector medium which is also currently in development. Compared to a single-event reconstruction, the combined reconstruction improves vertex resolution for reactor IBD positrons by up to a factor of 4.5 at the lowest energies. IBD-neutron vertex resolution was found to improve by more than 30% in most instances. Powerful background rejection with the coincidence reconstruction can be achieved by requiring a minimum quality of fit. This was found to reject up to 94% of accidental coincidences of uncorrelated background events, while retaining at least 97.5% of the IBD signal pairs.Comment: 26 pages, 20 figures, submitted to Nucl. Instr. Methods Phys. Res.

Hair cortisol as a novel biomarker of HPA suppression by inhaled corticosteroids in children

Background: Asthma is the most common chronic condition in childhood, and the recommended pharmacotherapy for long-term control includes the use of inhaled corticosteroids (ICS). ICS were designed to act at the site of inflammation in the lung, thus decreasing systemic absorption and reducing the risk of adverse effects associated with corticosteroid use (e.g., HPA suppression and its consequent effects). Available data show that measurement of hair cortisol successfully reflects endogenous cortisol levels. We sought to examine whether hair cortisol measurements can be used to identify HPA suppression surrounding ICS therapy in children with asthma.Methods:Hair samples were collected from the vertex posterior region of the head of 18 asthmatic children. We compared their hair cortisol concentration during ICS use with the concentration prior to ICS use.Results:During ICS therapy, median hair cortisol levels were twofold lower compared with the period of no ICS use (median 89.8 ng/g vs. 198.2 ng/g, P = 0.0015).Conclusion:Hair cortisol is an effective biomarker of the HPA suppression associated with ICS therapy and can be a sensitive tool for determining systemic effects of ICS use and monitoring adherence. Future research is needed to characterize the effect of untreated asthma on hair cortisol concentrations, if any

The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe

The preponderance of matter over antimatter in the early Universe, the dynamics of the supernova bursts that produced the heavy elements necessary for life and whether protons eventually decay --- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our Universe, its current state and its eventual fate. The Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed plan for a world-class experiment dedicated to addressing these questions. LBNE is conceived around three central components: (1) a new, high-intensity neutrino source generated from a megawatt-class proton accelerator at Fermi National Accelerator Laboratory, (2) a near neutrino detector just downstream of the source, and (3) a massive liquid argon time-projection chamber deployed as a far detector deep underground at the Sanford Underground Research Facility. This facility, located at the site of the former Homestake Mine in Lead, South Dakota, is approximately 1,300 km from the neutrino source at Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino charge-parity symmetry violation and mass ordering effects. This ambitious yet cost-effective design incorporates scalability and flexibility and can accommodate a variety of upgrades and contributions. With its exceptional combination of experimental configuration, technical capabilities, and potential for transformative discoveries, LBNE promises to be a vital facility for the field of particle physics worldwide, providing physicists from around the globe with opportunities to collaborate in a twenty to thirty year program of exciting science. In this document we provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess.Comment: Major update of previous version. This is the reference document for LBNE science program and current status. Chapters 1, 3, and 9 provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess. 288 pages, 116 figure

Report on the Depth Requirements for a Massive Detector at Homestake

This report provides the technical justification for locating a large detector underground in a US based Deep Underground Science and Engineering Laboratory. A large detector with a fiducial mass greater than 100 kTon will most likely be a multipurpose facility. The main physics justification for such a device is detection of accelerator generated neutrinos, nucleon decay, and natural sources of neutrinos such as solar, atmospheric and supernova neutrinos. The requirement on the depth of this detector will be guided by the rate of signals from these sources and the rate of backgrounds from cosmic rays over a very wide range of energies (from solar neutrino energies of 5 MeV to high energies in the range of hundreds of GeV). For the present report, we have examined the depth requirement for a large water Cherenkov detector and a liquid argon time projection chamber. There has been extensive previous experience with underground water Cherenkov detectors such as IMB, Kamioka, and most recently, Super-Kamiokande which has a fiducial mass of 22 kTon and a total mass of 50 kTon at a depth of 2700 meters-water-equivalent in a mountain. Projections for signal and background capability for a larger and deeper(or shallower) detectors of this type can be scaled from these previous detectors. The liquid argon time projection chamber has the advantage of being a very fine-grained tracking detector, which should provide enhanced capability for background rejection. We have based background rejection on reasonable estimates of track and energy resolution, and in some cases scaled background rates from measurements in water. In the current work we have taken the approach that the depth should be sufficient to suppress the cosmogenic background below predicted signal rates for either of the above two technologies. Nevertheless, it is also clear that the underground facility that we are examining must have a long life and will most likely be used either for future novel uses of the currently planned detectors or new technologies. Therefore the depth requirement also needs to be made on the basis of sound judgment regarding possible future use. In particular, the depth should be sufficient for any possible future use of these cavities or the level which will be developed for these large structures.Along with these physics justifications there are practical issues regarding the existing infrastructure at Homestake and also the stress characteristics of the Homestake rock formations. In this report we will examine the various depth choices at Homestake from the point of view of the particle and nuclear physics signatures of interest. We also have sufficient information about the existing infrastructure and the rock characteristics to narrow the choice of levels for the development of large cavities with long lifetimes. We make general remarks on desirable ground conditions for such large cavities and then make recommendations on how to start examining these levels to make a final choice. In the appendix we have outlined the initial requirements for the detectors. These requirements will undergo refinement during the course of the design. Finally, we strongly recommend that the geotechnical studies be commenced at the 4850 ft level, which we find to be the most suitable, in a timely manner