The Internet as Idea:For a Transcendental Philosophy of Technology

This article attempts to render the Internet an object of philosophical consideration. It does so by referring to Kant’s transcendental approach. The argument is that Kant’s “transcendental idealism” is one example of an approach focused on conditions that much contemporary philosophy of technology misunderstands or ignores. Diverse contemporary thinkers are engaged, including Verbeek, Brey, Stiegler, Clark and Chalmers, Feenberg, and Fuchs. The article considers how these thinkers stand in relation to tendencies towards determinism, subjectivism and excessive forms of optimism and pessimism in relation to the Internet. In terms of Kant’s transcendental idealism, I argue that contemporary philosophy of technology does not go far enough in considering the Internet as a “regulative idea.” In terms of broader transcendental approaches, I argue that openness to the transcendental calls into question presuppositions regarding what constitutes an “empirical” object of enquiry, opening philosophy of technology to important new areas of research

Anticipating the Internet: how the predictions of Paul Otlet, H.G. Wells and Vannevar Bush shaped the Digital Information Age

This is an historical research project that investigates predictions of future information technology made by Paul Otlet, H.G. Wells and Vannevar Bush, specifically those described in the Mundaneum, World Brain and Memex respectively. It is carried out by means of an extended review of the relevant Library and Information Science literature and aims to determine the reasons for their predictions, the relationship (if any) between them, and their influence upon the development of the modern-day Internet. After investigating the work of each figure in turn, further investigation is undertaken through a comparative analysis. It concludes that, although there are differences in approach and emphasis between the predictions, each of them was made in reaction to a common problem – the proliferation of published information – and each of them aimed to solve this problem by applying scientific means to improve the free flow of information throughout society, thus improving it for the benefit of all. Furthermore, their ideas stemmed from the same intellectual traditions of positivism and utopianism, and were expressed through technology, that although advanced for its time, was rapidly superseded by the rise of digital computing during the second half of the twentieth century. Finally, although the technology they used to express their predictions is now obsolete, and had little direct influence on the practical workings of the contemporary Internet, the works, concepts and ideas of Otlet, Wells and Bush remain highly relevant in today’s ever-increasingly Digital Age

Clinical and perceived quality of care for maternal, neonatal and antenatal care in Kenya and Namibia: the service provision assessment.

BackgroundThe majority of women in sub-Saharan Africa now deliver in a facility, however, little is known about the quality of services for maternal and newborn basic and emergency care, nor how this is associated with patient's perception of their experiences.MethodsUsing data from the Service Provision Assessment (SPA) survey from Kenya 2010 and Namibia 2009, we explore whether facilities have the necessary signal functions for providing emergency and basic maternal (EmOC) and newborn care (EmNC), and antenatal care (ANC) using descriptives and multivariate regression. We explore differences by type of facility (hospital, center or other) and by private and public facilities. Finally, we see if patient satisfaction (taken from exit surveys at antenatal care) is associated with the quality of services (specific services provided).ResultsWe find that most facilities do not have all of the signal functions, with 46 and 27 % in Kenya and 18 and 5 % in Namibia of facilities have high/basic scores in routine and emergency obstetric care, respectively. We found that hospitals preform better than centers in general and few differences emerged between public and private facilities. Patient perceptions were not consistently associated with services provided; however, patients had fewer complaints in private compared to public facilities in Kenya (-0.46 fewer complaints in private) and smaller facilities compared to larger in Namibia (-0.26 fewer complaints in smaller facilities). Service quality itself (measured in scores), however, was only significantly better in Kenya for EmOC and EmNC.ConclusionsThis analysis sheds light on the inadequate levels of care for saving maternal and newborn lives in most facilities in two countries of Africa. It also highlights the disconnect between patients' perceptions and clinical quality of services. More effort is needed to ensure that high quality supply of services is present to meet growing demand as an increasing number of women deliver in facilities

Withholding and withdrawing life-sustaining treatment in a patient's best interests: Australian judicial deliberations

•Intractable disputes about withholding and withdrawing life-sustaining treatment from adults who lack capacity are rare but challenging. Judicial resolution may be needed in some of these cases. •A central concept for judicial (and clinical) decision making in this area is a patient's “best interests”. Yet what this term means is contested. •There is an emerging Supreme Court jurisprudence that sheds light on when life-sustaining treatment will, or will not, be judged to be in a patient's best interests. •Treatment that is either futile or overly burdensome is not in a patient's best interests. Although courts will consider patient and family wishes, they have generally deferred to the views of medical practitioners about treatment decisions

Prevalence of Cardiometabolic Risk Factors in First Episode Psychosis Patients

INTRODUCTION Previous research in patients with schizophrenia have shown a high prevalence of metabolic syndrome and disease progression (~30-40%) which presents an increased risk for cardiovascular disease and long-term mortality (Correll et al. 2014; Mitchell et al. 2013). To date, little is known about the prevalence of existing cardiometabolic risk factors at time of diagnosis. This study presents a clinical overview of the cardiometabolic risk profile in young people presenting with early psychosis from a UK early intervention in psychosis service. METHODS: Participants (n=45; age 24.4 ± 4.5 yrs, 71% male, 88.9% White British) clinically diagnosed with a first episode psychosis with <3 months (n=39) or< 6 months (n=6) Duration of Untreated Psychosis (DUP) were assessed for anthropometric, lifestyle behaviours and clinical measurements including resting heart rate, blood pressure, blood lipids, HbA1c, and prolactin. The majority (n=38, 84.4%) were in receipt of antipsychotic medication (8.9% Aripiprazole, 28.9% Olanzepine, 31.1% Quetiapine, 4.4% Risperidone, 2.2% Paliperidone, 6.7% Clozapine). Seven participants (15.6%) were not on any antipsychotic medication. RESULTS Table 1 presents the cardiometabolic risk status and self reported lifestyle behaviours at baseline by sex of this first episode psychosis patient sample (n=45). • Participants had high prevalence of cardiometabolic risk factors due to elevated values for BMI (38.1%), abdominal adiposity (57.5%), high blood pressure (30.8% prehypertensive; 20.5% hypertensive), elevated resting heart rate (44.7%), hypercholesterolemia (27.9%), suboptimal HDL levels (25.6%), and hypertriglyceridemia (42.1%). • Participants also self-reported poor lifestyle habits including: smoking (55.8%), alcohol use (37.2%), substance use (16.3%), poor diet (53.5%), and a sedentary lifestyle (39.5%). CONCLUSION • Young people with psychosis are at increased risk for cardiometabolic disorders due to elevated clinical markers and unhealthy lifestyle behaviours. • Physical health interventions are needed early in the treatment process to address the increased risk for cardiometabolic disorders in individuals recently diagnose

Osteoblast response to disordered nanotopography

The ability to influence stem cell differentiation is highly desirable as it would help us improve clinical outcomes for patients in various aspects. Many different techniques to achieve this have previously been investigated. This concise study, however, has focused on the topography on which cells grow. Current uncemented orthopaedic implants can fail if the implant fails to bind to the surrounding bone and, typically, forms a soft tissue interface which reduces direct bone contact. Here, we look at the effect of a previously reported nanotopography that utilises nanodisorder to influence mesenchymal stromal cell (as may be found in the bone marrow) differentiation towards bone and to also exert this effect on mature osteoblasts (as may be found in the bone). As topography is a physical technique, it can be envisaged for use in a range of materials such as polymers and metals used in the manufacture of orthopaedic implants

Effect of dietary n‐3 PUFA supplementation on the muscle transcriptome in older adults

Dietary fish oil‐derived n‐3 PUFA supplementation can increase muscle mass, reduce oxygen demand during physical activity, and improve physical function (muscle strength and power, and endurance) in people. The results from several studies conducted in animals suggest that the anabolic and performance‐enhancing effects of n‐3 PUFA are at least in part transcriptionally regulated. The effect of n‐3 PUFA therapy on the muscle transcriptome in people is unknown. In this study, we used muscle biopsy samples collected during a recently completed randomized controlled trial that found that n‐3 PUFA therapy increased muscle mass and function in older adults to provide a comprehensive assessment of the effect of n‐3 PUFA therapy on the skeletal muscle gene expression profile in these people. Using the microarray technique, we found that several pathways involved in regulating mitochondrial function and extracellular matrix organization were increased and pathways related to calpain‐ and ubiquitin‐mediated proteolysis and inhibition of the key anabolic regulator mTOR were decreased by n‐3 PUFA therapy. However, the effect of n‐3 PUFA therapy on the expression of individual genes involved in regulating mitochondrial function and muscle growth, assessed by quantitative RT‐PCR, was very small. These data suggest that n‐3 PUFA therapy results in small but coordinated changes in the muscle transcriptome that may help explain the n‐3 PUFA‐induced improvements in muscle mass and function

Marginal abatement cost curves for UK agriculture, forestry, land-use and land-use change sector out to 2022

Greenhouse gas emissions from agriculture, land use, land use change and forestry (ALULUCF) are a significant percentage of UK industrial emissions. The UK Government is committed to ambitious targets for reducing emissions and all significant industrial sources are coming under increasing scrutiny. The task of allocating shares of future reductions falls to the newly appointed Committee on Climate Change (CCC), which needs to consider efficient mitigation potential across a range of sectors. Marginal abatement cost curves are derived for a range of mitigation measures in the agriculture and forestry sectors over a range of adoption scenarios and for the years 2012, 2017 and 2022. The results indicate that in 2022 around 6.36 MtCO2e could be abated at negative or zero cost. Further, in same year over 17% of agricultural GHG emissions (7.85MtCO2e) could be abated at a cost of less than the 2022 Shadow Price of Carbon (£34tCO2e).Environmental Economics and Policy,

A Perspective on Development Flight Instrumentation and Flight Test Analysis Plans for Ares I-X

NASA. s Constellation Program will take a significant step toward completion of the Ares I crew launch vehicle with the flight test of Ares I-X and completion of the Ares I-X post-flight evaluation. The Ares I-X flight test vehicle is an ascent development flight test that will acquire flight data early enough to impact the design and development of the Ares I. As the primary customer for flight data from the Ares I-X mission, Ares I has been the major driver in the definition of the Development Flight Instrumentation (DFI). This paper focuses on the DFI development process and the plans for post-flight evaluation of the resulting data to impact the Ares I design. Efforts for determining the DFI for Ares I-X began in the fall of 2005, and significant effort to refine and implement the Ares I-X DFI has been expended since that time. This paper will present a perspective in the development and implementation of the DFI. Emphasis will be placed on the process by which the list was established and changes were made to that list due to imposed constraints. The paper will also discuss the plans for the analysis of the DFI data following the flight and a summary of flight evaluation tasks to be performed in support of tools and models validation for design and development