Table_1_Cervical cancer incidence, mortality, and burden in China: a time-trend analysis and comparison with England and India based on the global burden of disease study 2019.DOCX

BackgroundCervical cancer is the fourth highest incidence of malignancy in the world and a common cause of cancer death in women. We assessed the trends of incidence and mortality and disability-adjusted life year (DALY) in China, England and India from 1990 to 2030.MethodData were obtained from the Global Burden of Disease (GBD) database. We collected the number and rate of incidence, death and DALY from 1990 to 2019 and calculated the estimated annual percentage change (EAPC). Further analysis was carried out by ages and years. We also collected attributable risk factors to cervical cancer. Finally, we utilized the Bayesian Age-Period-Cohort (BAPC) model to forecast trends in the rate of age-standardized incidence (ASIR) and age-standardized death (ASDR) the for the next decade.ResultGlobally, the incidence of cervical cancer cases increased from 335,641.56 in 1990 to 565,540.89 in 2019. In 2019, the ASIR and ASDR of cervical cancer were higher than those of India but lower than those of England. Furthermore, unsafe sex and smoking emerge as prominent risk factors for cervical cancer. Over the next decade, ASIR and ASDR are expected to decline in China and England, while India’s ASIR is still on an upward trend and ASDR is on a downward trend.ConclusionThe epidemiological data of cervical cancer in these three countries reflects the influence of different stages of development and healthcare systems. Trends over the next decade suggest that China and India still face a huge burden of cervical cancer. When England has made significant progress, China and India need to take more measures to improve the prevention and control of cervical cancer.</p

First preoperative risk assessments.

<p>First preoperative risk assessments.</p

Preoperative risk assessments.

<p>Preoperative risk assessments.</p

X-ray images of the right femoral neck fracture in a 72-year old male patient with chronic renal failure before and after hemiarthroplasty.

<p>(A) Preoperative imaging shows compression fractures on the femoral neck of the right hip and shortening deformity of the femoral neck. (B) Representative images taken 6 months after right femoral head arthroplasty. (C) At 24 months of follow-up, the prosthesis was in the correct position. On subsequent X-ray images, there were no further changes.</p

Retrosynthetic Analysis-Guided Breaking Tile Symmetry for the Assembly of Complex DNA Nanostructures

Current tile-based DNA self-assembly produces simple repetitive or highly symmetric structures. In the case of 2D lattices, the unit cell often contains only one basic tile because the tiles often are symmetric (in terms of either the backbone or the sequence). In this work, we have applied retrosynthetic analysis to determine the minimal asymmetric units for complex DNA nanostructures. Such analysis guides us to break the intrinsic structural symmetries of the tiles to achieve high structural complexities. This strategy has led to the construction of several DNA nanostructures that are not accessible from conventional symmetric tile designs. Along with previous studies, herein we have established a set of four fundamental rules regarding tile-based assembly. Such rules could serve as guidelines for the design of DNA nanostructures

The Kaplan-Meier survival curves analysis in patients with or without surgical treatment.

<p>Survival curves in 32 study patients. Based on surgical risk assessment, 28 patients were selected for surgical treatment. The remaining 4 patients could not undergo the surgery and dead within 30 days. Furthermore, mortality rates in the early surgery group were equal with the delayed surgery group.</p

Demographic and clinical characteristics of study patients.

<p>Demographic and clinical characteristics of study patients.</p

Chest X-ray images of a 72-year old male patient with femoral neck fracture complicated with chronic renal failure.

<p>(A) Frontal projection. (B) Lateral projection.</p

IKK inhibitor reversed the IFN-β induction and virus replication suppression mediated by poly(I∶C) pretreatment.

<p>HepG2 cells were incubated in control or IKK inhibitor for 30 min before poly(I∶C) pretreatment and virus infection. (A) Cells were harvested for measurement of IFN-β expression level; (B) Immunofluorescence microscopy. Cells were fixed at 24 h p.i. and incubated with DENV2 prM antibody. Panel a, mock infected; b, DENV2; c, DMSO+poly(I∶C)+DENV2; d, BMS345541+poly(I∶C)+DENV2; (C) Percentages of positive-stained cells determined by PicCnt 100×; (D) Extracellular viral production determined by TCID50. Supernatants were harvested at 24 h p.i. and titered on C6/36 cells. Error bars represent the standard error of mean from the average of three experiments. Student's <i>t</i> test, *, p<0.05; **, p<0.01; ***, p<0.001.</p

Electrophysiological studies were performed at 4 w, 8 w and 12 w after surgery.

<p>Comparisons of amplitude of CMAP (A), NCV (B) and latency onset of CMAP (C) were performed. The Representative recordings from the CS+ES group (D), NCS+ES group (E) and CS−ES group (F) were shown. All data were expressed as the mean±standard deviation. *<i>p</i><0.05 for the comparison with CS−ES group. ^#<i>p</i><0.05 for the comparison with NCS+ES group.</p