1 research outputs found
Photodegradable Coordination Polymer Particles for Light-Controlled Cargo Release
Stimuli-responsive
coordination polymer particles (CPPs) show great
promise for encapsulating and releasing cargos due to their unique
and highly tailorable structures and properties. In particular, photoresponsive
CPPs have received enormous interest, as noninvasive light can be
spatially and temporally controlled, resulting in great safety and
efficiency. In this work, we report the design and synthesis of novel
photodegradable CPPs by infinite coordination polymerization of Zn<sup>2+</sup> and a photocleavable organic linker containing <i>o</i>-nitrobenzyl derivatives. We further demonstrate that these novel
photodegradable CPPs are able to efficiently encapsulate cargos and
are applicable for on-command drug release upon low-power UV light
irradiation (5.78 mW/cm<sup>2</sup>). Because light is a highly desirable
remote-trigger and can be used externally, we expect that these photodegradable
CPPs can provide a unique platform for controlled cargo release