691 research outputs found

    Implementation of an efficient Fuzzy Logic based Information Retrieval System

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    This paper exemplifies the implementation of an efficient Information Retrieval (IR) System to compute the similarity between a dataset and a query using Fuzzy Logic. TREC dataset has been used for the same purpose. The dataset is parsed to generate keywords index which is used for the similarity comparison with the user query. Each query is assigned a score value based on its fuzzy similarity with the index keywords. The relevant documents are retrieved based on the score value. The performance and accuracy of the proposed fuzzy similarity model is compared with Cosine similarity model using Precision-Recall curves. The results prove the dominance of Fuzzy Similarity based IR system.Comment: arXiv admin note: substantial text overlap with http://ntz-develop.blogspot.in/ , http://www.micsymposium.org/mics2012/submissions/mics2012_submission_8.pdf , http://www.slideshare.net/JeffreyStricklandPhD/predictive-modeling-and-analytics-selectchapters-41304405 by other author

    The Vulnerable Phase of Heart Failure

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    Extended Treatment with a High Dosage of EGCG to Rescue Appendicular Bone Abnormalities in a Down Syndrome Mouse Model

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    poster abstractIndividuals with Down syndrome (DS) show significant abnormalities in cognitive abilities, muscle tone, and bone homeostasis. DS is caused by a triplication of the 21st human chromosome (Hsa21). Previous research conducted by our lab using mouse models indicates that three copies of Dyrk1a causes the appendicular skeletal deficits associated with DS. Ts65Dn mouse model carries 50% of the genes homologous to Hsa21, and exhibit excellent phenotypic model for the skeletal deficits seen in individuals with DS, such as low bone mineral density, altered bone structure, and decreased cortical bone. Epigallocatechin-3-gallate (EGCG) is a green tea polyphenol that inhibits Dyrk1a activity. In a previous study, we showed that a three-week, low dose (10mg/kg/day) treatment of EGCG rescued bone mineral density, and trabecular bone to that of euploid levels, but not cortical bone. We hypothesize that increasing the concentration and duration of the treatment will be sufficient enough to more fully restore bone abnormalities by rescuing femoral bone mineral density, bone volume, and improving overall bone strength. This project explores the effects of using a prolonged seven-week, high dosage (100mg/kg/day) treatment on specific bone phenotypes. Dual Energy X-ray absorptiometry (DXA), MicroCT, and mechanical testing will be used as our means of analysis of the treated and untreated bones

    Examining the Effects of a Peer-Mediated Social Skills Intervention on the Prosocial Behaviors of Elementary Students with Emotional and Behavioral Disorders

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    Students with Emotional and Behavioral Disorders represent part of the population of students who receive special education services, and the social skill deficits that they present makes it so that they are less likely to pass their classes and more likely to drop out of school than their typical peers. The social skill deficits of these students often lead to a variety of negative factors including poor relationships and academic achievement. The purpose of this study was to examine the effects of a peer-mediated social skills intervention on fourth and fifth grade students in a public-school setting. The current study explicitly taught students the target social skills of sharing, compliment giving, and sportsmanship using modeling, role-play, and discussion with feedback. Results of the study indicated participants increased target skills in intervention phases with the skill of sharing showing strong results for all three participants and sportsmanship skills showing strong results for one participant. Target skills declined somewhat in maintenance phases for all participants but remained above baseline levels. Two participants generalized the skill of sharing to the recess setting with untrained peers, while the third participant generalized sportsmanship skills to the recess setting

    The Role Of Adult Stem Cells And Tumor Necrosis Factor In Peripheral Neuropathy

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    Peripheral neuropathies are a significant cause of morbidity and mortality, with a population prevalence of 2,400 per 100,000 (2.4%) that increases in the elderly to 8,000 per 100,000 (8%)(C. N. Martyn and R. A. Hughes, 1997). The variations in symptom distribution and etiologic attribution have resulted in the classification of over 100 types of peripheral neuropathy with specific patterns of development and prognoses. In the first study, we use a mouse model of hereditary peripheral neuropathy that results in hind-limb paralysis to investigate the therapeutic efficacy of adult, adipose derived stem cells (ADSC). The paralyzed mice that received ADSC transplantation demonstrated significantly improved motor function, likely due to stromal support provided by ADSCs. The ultrastructure of the nerve was not significantly improved, indicating that the threshold of functional motor improvement can be met through alternative means. In the second study, we developed a process to identify highly-connected genes in a model of peripheral nerve development using entropy maximized network analysis of gene microarrays. We found that Tumor Necrosis Factor (TNF) mediates axonal-Schwann cell communication, and that disruption of TNF signaling results in sensory and tissue dysfunction. These findings indicate that the threshold of wild-type physiological function in peripheral nerve development can be addressed by disrupting or strengthening specific signaling processes without significant changes to tissue structure
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