512 research outputs found

    ANTEPROJETO DE UM TERMINAL URBANO PARA O MUNIC√ćPIO DE FRAIBURGO- SC.

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    O presente trabalho tem por finalidade desenvolver um estudo para um anteprojeto arquitet√īnico de um novo terminal urbano para o munic√≠pio de Fraiburgo - SC, que atualmente est√° instalado em um local inapropriado, sobre um terreno de pra√ßa p√ļblica. O objetivo √© definir um local apropriado para acomodar e recepcionar os usu√°rios de √īnibus de linha urbana com seguran√ßa, proporcionando acessibilidade e conforto, que ofere√ßa solu√ß√Ķes alternativas para o transporte p√ļblico, analisando √†s quest√Ķes de mobilidade existentes na cidade. A pesquisa foi realizada a partir de pesquisas de referencial te√≥rico que mostra a hist√≥ria da cidade e do transporte p√ļblico, modelos de √īnibus j√° utilizados, acessibilidade e sustentabilidade. Tamb√©m foram realizados estudos de caso, que avaliaram edifica√ß√Ķes de terminais em √Ęmbito internacional e nacional, com caracter√≠sticas semelhantes ao tema proposto. O levantamento de dados realizado com visitas in loco, mostra as caracter√≠sticas do terminal atual. Por fim, quantificou-se a demanda atrav√©s de dados dispostos pelo IBGE (Instituto Brasileiro de Geografia e Estat√≠stica), referentes a popula√ß√£o. Os resultados obtidos permitiram efetivar a escolha do terreno, para qual a proposta foi desenvolvida, a qual conta com an√°lise do perfil dos usu√°rios, programa de necessidades, pr√©-dimensionamento, organograma, fluxogramas, embasamentos que contribu√≠ram para posterior defini√ß√£o do conceito e partido do anteprojeto.¬† ¬† ¬† ¬† ¬†¬†Palavras-chave:Arquitetura. Mobilidade Urbana. Acessibilidade.

    Overview of the organization of protease genes in the genome of Leishmania spp

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    Background: The genus Leishmania includes protozoan parasites that are able to infect an array of phlebotomine and vertebrate species. Proteases are related to the capacity of these parasites to infect and survive in their hosts and are therefore classified as virulence factors. Findings: By analyzing protease genes annotated in the genomes of four Leishmania spp [Leishmania (Leishmania) infantum, L. (L.) major, L. (L.) mexicana and L. (Viannia) braziliensis], these genes were found on every chromosome of these protozoa. Four protease classes were studied: metallo-, serine, cysteine and aspartic proteases. Metalloprotease genes predominate in the L. (V.) braziliensis genome, while in the other three species studied, cysteine protease genes prevail. Notably, cysteine and serine protease genes were found to be very abundant, as they were found on all chromosomes of the four studied species. In contrast, only three aspartic protease genes could be detected in these four species. Regarding gene conservation, a higher number of conserved alleles was observed for cysteine proteases (42 alleles), followed by metalloproteases (35 alleles) and serine proteases (15 alleles). Conclusions: The present study highlights substantial differences in the organization of protease genes among L. (L.) infantum, L. (L.) major, L. (L.) mexicana and L. (V.) braziliensis. We observed significant distinctions in many protease features, such as occurrence, quantity and conservation. These data indicate a great diversity of protease genes among Leishmania species, an aspect that may be related to their adaptations to the peculiarities of each microenvironment they inhabit, such as the gut of phlebotomines and the immune cells of vertebrate hosts

    Tree-Network Overrun Model Associated with Pilots’ Actions and Flight Operational Procedures

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    The runway excursions are defined as the exit of an aircraft from the surface of the runway. These excursions can take place at takeoff or at landing and consist of two types of events: veer off and overrun. This last one, which occurs when the aircraft exceeds the limits at the end of the runway, is the event of interest in the current study. This chapter aims to present an accident model with a new approach in aeronautical systems, based on the tasks of the pilots related to the operational procedures necessary for the approach and landing, in order to obtain the chain of events that lead to this type of accident. Thus, the tree-network overrun model (TNO model) was proposed, unlike most traditional models, which consider only the hardware failures or which do not satisfactorily explain the interrelationship between the factors influencing the operator. The proposed model is developed in a fault tree and transformed into a Bayesian network up to the level of the basic elements. The results showed the qualitative model of the main tasks performed by the pilots and their relation to the accident. It has also been suggested how to find and estimate the probability of factors that can impact on each of the tasks

    O trabalho do intérprete de libras no ambiente escolar

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    Resumo: A pesquisa sobre o trabalho do int√©rprete de Libras no ambiente escolar, objetiva identificar a rela√ß√£o dial√≥gica entre o professor regente da disciplina e o int√©rprete de Libras educacional no contexto da sala de aula comum. Assim como compreender as atribui√ß√Ķes do int√©rprete de Libras educacional na sala comum do ensino regular, diagnosticando suas compet√™ncias no contexto escolar. Para a fundamenta√ß√£o te√≥rica t√™m-se os estudos de Briega (2019), Cunha (2016), Quixaba (2015), os documentos, foram consultados a Lei n¬ļ 10.436/2002, Lei 12.319/10, Decreto n¬ļ 5.626/05. O ILS, no contexto educacional atua como mediador da comunica√ß√£o, o que n√£o o limita de orientar os professores, numa perspectiva colaborativa, sobre o processo de aprendizagem do estudante com surdez e as metodologias que podem ser adotadas na pr√°tica docente. Palavras- chave: Ambiente escolar. Atua√ß√£o profissional. Int√©rprete de Libras. &nbsp

    O trabalho do intérprete de libras no ambiente escolar

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    Resumo: A pesquisa sobre o trabalho do int√©rprete de Libras no ambiente escolar, objetiva identificar a rela√ß√£o dial√≥gica entre o professor regente da disciplina e o int√©rprete de Libras educacional no contexto da sala de aula comum. Assim como compreender as atribui√ß√Ķes do int√©rprete de Libras educacional na sala comum do ensino regular, diagnosticando suas compet√™ncias no contexto escolar. Para a fundamenta√ß√£o te√≥rica t√™m-se os estudos de Briega (2019), Cunha (2016), Quixaba (2015), os documentos, foram consultados a Lei n¬ļ 10.436/2002, Lei 12.319/10, Decreto n¬ļ 5.626/05. O ILS, no contexto educacional atua como mediador da comunica√ß√£o, o que n√£o o limita de orientar os professores, numa perspectiva colaborativa, sobre o processo de aprendizagem do estudante com surdez e as metodologias que podem ser adotadas na pr√°tica docente. Palavras- chave: Ambiente escolar. Atua√ß√£o profissional. Int√©rprete de Libras. &nbsp

    Bioemulsifier produced by Yarrowia lipolytica using residual glycerol as a carbon source

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    Bioemulsifier is bioactive molecules produced by different microorganisms with reducing power and surface and interfacial tension. Among the microorganisms producing this molecule is yeast, which can produce different bioemulsifiers in different substrates. Undoubtedly, this biomolecule has excellent potential for industrial applications, but high production costs are the biggest problem in production. Aiming at cost reduction the present study using crude residual glycerol for biosurfactant production by Yarrowia lipolytica. Then isolates were grown in residual glycerol compound medium, rotating 200 rpm at 28¬ļC for 48 hours. Bioemulsifier production was observed by analysis of dry biomass, pH, surface tension and emulsification index. The results indicated that the emulsion produced from biosurfactant using glycerol as a carbon source by Y. lipolytica has the potential for bioemulsifier production. All isolates obtained similar results for all analyzes, indicating that this species has a linear production among the isolates. Biomass reached 10.08 ¬Ī 0.62 g.L-1, there was a sharp drop in pH reaching 4.6, surface tension averaged 41.7 mN.m-1 and emulsification index reached 56%. The isolates tested show potential for bioemulsifier production using glycerol as an unconventional carbon source

    Increased Percentages of T Helper Cells Producing IL-17 and Monocytes Expressing Markers of Alternative Activation in Patients with Sepsis

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    BACKGROUND: A shift from Th1 to Th2 as well as an increase in Treg CD4+T cell subsets has been reported in septic patients (SP). Furthermore, these patients display modulation of monocyte function, with reduced production of pro-inflammatory cytokines upon LPS stimulus, which resembles the phenotype of alternatively activated macrophages. In this study, we evaluated the percentages of T cells differentiated into Th1, Th17 and Treg subsets, as well as the percentage of monocytes expressing markers of alternatively activated monocytes/macrophages (AAM) in SP. METHODOLOGY/PRINCIPAL FINDINGS: Peripheral blood mononuclear cells (PBMC) were obtained from 32 healthy volunteers (HV) and from SP at admission (D0, n‚Ää=‚Ää67) and after 7 days of therapy (D7, n‚Ää=‚Ää33). Th1 and Th17 (CD3+CD8-) lymphocytes were identified by the intracellular detection of IFN-ő≥ and IL-17, respectively, spontaneously and after PMA/Io stimulation, and Treg cells were identified by Foxp3+CD127- expression. Monocytes were evaluated for CD206 and CD163 expression. Absolute numbers of CD4+T lymphocytes were measured in whole blood samples by flow cytometry. The Mann-Whitney or Wilcoxon test was applied, as appropriate. The percentage of Th1 cells was lower in SP than in HV at admission after PMA/Io stimulation, whereas the percentage of Th17 cells was higher. In patients' follow-up samples, a higher percentage of Th1 cells and a lower percentage of Th17 cells were observed on D7 compared with the D0 samples. Treg cells remained unchanged. Septic patients showed a markedly increased proportion of monocytes expressing CD163 and CD206. CONCLUSIONS/SIGNIFICANCE: Upon in vitro stimulus, the percentage of T helper lymphocytes producing IL-17 was higher in SP than in HV at admission, and the percentage producing IFN-ő≥ was lower, a pattern that was reversed during follow-up. The increased expression of CD163 and CD206 indicates that monocytes may acquire the AAM phenotype during sepsis

    Biology education research: Academic production characteristics of the graduate program in science education at the Federal Rural University of Pernambuco, Brazil

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    Este artigo apresenta um estudo referente √† pesquisa em ensino de Biologia, pautado na descri√ß√£o, an√°lise e caracteriza√ß√£o das disserta√ß√Ķes defendidas no Programa de P√≥s-Gradua√ß√£o em Ensino de Ci√™ncias (PPGEC), da Universidade Federal Rural de Pernambuco (UFRPE). Para tal, foram analisadas 41 disserta√ß√Ķes defendidas no per√≠odo de 2003 a 2009, a partir de descritores propostos pelo Centro de Documenta√ß√£o em Ensino de Ci√™ncias (CEDOC), da Faculdade de Educa√ß√£o da Universidade Estadual de Campinas (UNICAMP): ano de defesa, autor e orientadores, n√≠vel de ensino, foco tem√°tico e g√™nero do trabalho acad√™mico. Os resultados mostraram que a pesquisa em Ensino de Biologia do PPGEC/UFRPE apresenta caracter√≠sticas comuns √† pesquisa nessa √°rea em √Ęmbito nacional, como o predom√≠nio de problem√°ticas que envolvem a Educa√ß√£o B√°sica. E, tamb√©m, caracter√≠sticas singulares que refletem o processo de implanta√ß√£o e consolida√ß√£o do curso de mestrado do PPGEC/UFRPE.v. 21n.228530

    A Agricultura Familiar no Município de Amambai/MS: uma análise dos desafios na comercialização da Associação de Agricultores Familiares (ASSAFAM)

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    O presente artigo visa analisar o processo de comercializa√ß√£o de alimentos entre o segmento da agricultura familiar e o mercado institucional, mediante o Programa de Aquisi√ß√£o de Alimentos (PAA) desenvolvido na Associa√ß√£o dos Agricultores Familiares de Amambai (Assafam), enfocando na sua modalidade Compra Institucional (CI), considerando o conceito de qualidade ampla como guia para a compreens√£o dos poss√≠veis avan√ßos e barreiras existentes e consequentemente a percep√ß√£o dos fatores que contribuem com estes dois aspectos. O PAA e as chamadas p√ļblicas, apesar de apresentarem algumas barreiras e dificuldades para sua implanta√ß√£o e efetividade, ainda √© visto como instrumentos de fortalecimento e de inclus√£o do segmento da agricultura familiar no mercado institucional. A proposta do PAA revela estar mais relacionada √† qualidade ampla, podendo conduzir a constru√ß√£o de editais, mais abrangentes e eficazes em seus processos de comercializa√ß√£o. Compreende-se a necessidade de algumas estrat√©gias de aproxima√ß√£o e di√°logo com as organiza√ß√Ķes de agricultores familiares com o intuito de superar dificuldades existentes no processo, aprimorando assim a rela√ß√£o de compra e venda entre o segmento da agricultura familiar e os √≥rg√£os p√ļblicos.Palavras-Chave: controle de qualidade; desperd√≠cio; associa√ß√£o; agricultura familiar.Family Farming in the Municipality of Amambai-MS, Brazil: an analysis of the commercialization challenges of the Family Farmers Association (ASSAFAM)ABSTRACTThis article aims to analyze the process of food commercialization between the family farming segment and the institutional market, through the Food Acquisition Program (PAA) developed at the Amambai Family Farmers Association (Assafam), focusing on its Institutional Purchasing modality. (CI), considering the concept of broad quality as a guide for understanding the possible advances and existing barriers and consequently the perception of the factors that contribute to these two aspects. The PAA and the public calls, despite presenting some barriers and difficulties for their implementation and effectiveness, are still seen as instruments for strengthening and including the family farming segment in the institutional market. The PAA proposal reveals to be more related to the broad quality and may lead to the construction of edicts, more comprehensive and effective in its commercialization processes. It is understood the need for some strategies of approach and dialogue with family farmers organizations in order to overcome existing difficulties in the process, thus improving the buying and selling relationship between the family farming segment and public agencies.Keywords: quality control; waste; association; family farming
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