Localizing urban SDGs indicators for an integrated assessment of urban sustainability: a case study of Hainan province

Due to the Sustainable Development Goals (SDGs) being designed at both national and globally applicable level, it is challenging to adequately reflect the local context and characteristics in different urban regions without fully utilizing big earth data. To effectively address this issue, this study localized 73 urban indicators for 13 SDGs and both assessed and forecasted urban sustainability across 18 cities in Hainan (2010-2030) using big earth data. Our analysis specifically focused on indicator score, goal score, SDG index, SDG spatial spillover effect, and trade-offs and synergies. The results indicated an overall upward trend in sustainable development in Hainan province, predicting achievement of the SDGs by 2030. The SDG index and spatial spillover showed a pattern of ‘high in the north and south, low in the middle’. While synergies outweighed trade-offs, trade-offs increased at a faster pace. More specifically, the average SDG index increased from 29.85 in 2010–60.09 in 2018, with a projected score of 89.76 by 2030. During 2010–2018, the synergy-to-trade-off ratio declined from 3.91–1.84, driven by a trade-off growth rate 2.03 times higher than synergy. Our work provides a valuable localized case method, and data support for monitoring sustainable development at the global urban level.</p

Ultralight Porous Cu Nanowire Aerogels as Stable Hosts for High Li-Content Metal Anodes

Using porous copper (Cu) as the host is one of the most effective approaches to stabilize Li metal anodes. However, the most widely used porous Cu hosts usually account for the excessive mass proportion of composite anodes, which seriously decreases the energy density of Li metal batteries. Herein, an ultralight porous Cu nanowire aerogel (UP-Cu) is reported as the Li metal anode host to accommodate a high mass loading of Li content of 77 wt %. Specifically, the Li/UP-Cu electrode displays a satisfactory gravimetric capacity of 2715 mAh g–1, which is higher than that of the most reported Li metal composite anodes. The UP-Cu host achieves a high Coulombic efficiency of ∼98.9% after 250 cycles in the half cell and exceptional electrochemical stability under high-current-density and deep-plating-stripping conditions in the symmetrical cell. The Li/UP-Cu|LiFePO4 battery displays a specific capacity of 102 mAh g–1 at 5 C for 5000 cycles. The Li/UP-Cu|LiFePO4 pouch cell achieves a significantly high capacity of 146.3 mAh g–1 with a high capacity retention of 95.83% for 360 cycles. This work provides a lightweight porous host to stabilize Li-metal anodes and maintain their high mass-specific capacity

Supplementary document for Long-term monitoring chlorophyll-a concentration using HJ-1 A/B imagery and machine learning algorithms in typical lakes, a cold semi-arid region - 6943993.pdf

Supplemental Documen

Effects of PTH withdrawal on mineralization.

<p>Mineralized nodule formation was assessed by Alizarin red S (ARS) staining 20 days after differentiation. The blank control group without the supplement of bPTH and the osteogenic induction in the cell culture was performed as a negative control. Original magnification 100×.</p

Effects of PTH withdrawal on osteoblast proliferation.

<p>Cells were grown in microtiter plates in a final volume of 200 μL culture medium per well for 2–20 days. MTT assays were performed after 48 h. (A) Cell proliferation appears to be downregulated in the first 8 days, and inhibited after 10 days of culture in the continuously-treated bPTH groups. The effect of inhibition increases with the concentration of bPTH. (B) Although osteoblast proliferation coordinately declined in the PTH-C 100 ng/mL and PTH Day 1–10 groups, it rebounded after bPTH withdrawal in the PTH Day 1–10 group. *Significantly different compared to the PTH-C 100 ng/mL group at the same time point, <i>P</i> < 0.05.</p

Baseline characteristics of patients with parathyroidectomy.

<p>Baseline characteristics of patients with parathyroidectomy.</p

Effects of PTH withdrawal on calcium and phosphorus in culture.

<p>Calcium and phosphorus derived from control and bPTH treated cultures at different time points. In the control group, there was a gradual decline of calcium and phosphorus content that reached a plateau after day 16. Similarly, calcium and phosphorus content slowly decreased with time in continuous bPTH cultures. Although the initial calcium and phosphorus content in cultures treated with transient bPTH decreased more slowly than in controls, they showed a rapid decline after bPTH withdrawal on day 10 and attained similar levels as control. *^{, #}Significantly different compared with control at the same time point, <i>P</i>< 0.05.</p

Effects of PTH withdrawal on AKP activity.

<p>In control cultures, AKP activity increased with time and reached a plateau after 14 days. In contrast, AKP activity declined from day 4 to day 10 and did not increase over time in the continuous PTH cultures. In the PTH Day 1–10 group that was treated with bPTH on days 1 to 10, AKP activity rebounded after withdrawal of bPTH and was significantly higher than controls and continuously bPTH-treated cells from day 16. AKP activity did not fully recover until day 20. *^{, #}Significantly different compared to control at the same time point, <i>P</i> < 0.05.</p

Additional file 1 of Genomics insights into flowering and floral pattern formation: regional duplication and seasonal pattern of gene expression in Camellia

Additional file 1: Fig. S1. The karyotyping and Kmer-based analyses of the cjaND genome. Fig. S2. The Hi-C heatmap shows the interaction of the chromosome. Fig. S3. The segregation patterns of the genetic makers. Fig. S4. The evolution and expression pattern of CjAGs. Fig. S5. Co-expression network analysis of CjAG1 and CjAG2. Fig. S6. Identification of annual rhythmic genes in C. japonica. Fig. S7. Identification of annual rhythmic genes in C. azalea. Fig. S8. The relationship of co-expression module of common rhythmic genes. Fig. S9. The seasonal expression genes participating in different pathways in C. japonica and C. azalea. Fig. S10. Identification of FT genes from C. japonica and C. azalea

Targeted Delivery of LXR Agonist Using a Site-Specific Antibody–Drug Conjugate

Liver X receptor (LXR) agonists have been explored as potential treatments for atherosclerosis and other diseases based on their ability to induce reverse cholesterol transport and suppress inflammation. However, this therapeutic potential has been hindered by on-target adverse effects in the liver mediated by excessive lipogenesis. Herein, we report a novel site-specific antibody–drug conjugate (ADC) that selectively delivers a LXR agonist to monocytes/macrophages while sparing hepatocytes. The unnatural amino acid <i>para</i>-acetylphenylalanine (pAcF) was site-specifically incorporated into anti-CD11a IgG, which binds the α-chain component of the lymphocyte function-associated antigen 1 (LFA-1) expressed on nearly all monocytes and macrophages. An aminooxy-modified LXR agonist was conjugated to anti-CD11a IgG through a stable, cathepsin B cleavable oxime linkage to afford a chemically defined ADC. The anti-CD11a IgG-LXR agonist ADC induced LXR activation specifically in human THP-1 monocyte/macrophage cells in vitro (EC50–27 nM), but had no significant effect in hepatocytes, indicating that payload delivery is CD11a-mediated. Moreover, the ADC exhibited higher-fold activation compared to a conventional synthetic LXR agonist T0901317 (Tularik) (3-fold). This novel ADC represents a fundamentally different strategy that uses tissue targeting to overcome the limitations of LXR agonists for potential use in treating atherosclerosis