Submission of Evidence on Online Violence Against Women to the UN Special Rapporteur on Violence Against Women, its Causes and Consequences, Dr Dubravka Šimonović

Figure S1. B3GALNT2 levels determined by W.B. and ROC curve. a–c Relative mRNA expression of B3GALNT2 in HCC tumor tissues and normal liver tissues obtained from GSE76427, GSE36376, and TCGA-LIHC datasets. d Western blot analysis of B3GALNT2 levels in 24 pairs of HCC tissues. T HCC tumor tissue, N adjacent non-tumor tissue. e ROC curve analysis of the sensitivity and specificity for the predictive value of TNM model, B3GALNT2 expression, and the combination model. (TIFF 546 kb

Additional file 8: of Increased B3GALNT2 in hepatocellular carcinoma promotes macrophage recruitment via reducing acetoacetate secretion and elevating MIF activity

Table S4. Genes correlated with B3GALNT2 from TCGA data and their Functional enrichments. (XLSX 29 kb

Additional file 8: of Increased B3GALNT2 in hepatocellular carcinoma promotes macrophage recruitment via reducing acetoacetate secretion and elevating MIF activity

Table S4. Genes correlated with B3GALNT2 from TCGA data and their Functional enrichments. (XLSX 29 kb

Additional file 6: of Increased B3GALNT2 in hepatocellular carcinoma promotes macrophage recruitment via reducing acetoacetate secretion and elevating MIF activity

Figure S4. The total ion chromatogram for metabolomics analysis. a The total ion chromatogram (TIC) of 7402-B3GALNT2 and 7402-control in negative ion mode. b The total ion chromatogram (TIC) of 7402-B3GALNT2 and 7402-control in positive ion mode. (TIFF 574 kb

Additional file 10: of Increased B3GALNT2 in hepatocellular carcinoma promotes macrophage recruitment via reducing acetoacetate secretion and elevating MIF activity

Figure S6. KEGG pathway schematic. KEGG pathway schematic of butanoate metabolism marked with the enzymes and metabolites correlated with B3GALNT2. Blue is for enzymes, red is for metabolites. (TIFF 82 kb

Additional file 5: of Increased B3GALNT2 in hepatocellular carcinoma promotes macrophage recruitment via reducing acetoacetate secretion and elevating MIF activity

Figure S3. Secreted levels of some cytokines. Secreted levels of macrophage-recruiting cytokines in the culture media of B3GALNT2 overexpression or knock down HCC cells as determined by ELISA. (TIFF 153 kb

Additional file 2: of Increased B3GALNT2 in hepatocellular carcinoma promotes macrophage recruitment via reducing acetoacetate secretion and elevating MIF activity

Table S1. Relationships between the B3GALNT2expression and the clinicopathological variables of hepatocellular carcinoma patients. (DOCX 20 kb

Additional file 7: of Increased B3GALNT2 in hepatocellular carcinoma promotes macrophage recruitment via reducing acetoacetate secretion and elevating MIF activity

Table S3. B3GALNT2-associated metabolites determined by LC-MS and the functional enrichment of KEGG pathway on these metabolites. (XLSX 39 kb

Additional file 3: of Increased B3GALNT2 in hepatocellular carcinoma promotes macrophage recruitment via reducing acetoacetate secretion and elevating MIF activity

Table S2. Univariate and multivariate Cox regression analysis for overall survival of hepatocellular carcinoma patients. (DOCX 20 kb