Datasheet1_Comparative observation of common tracers in sentinel lymph node biopsy of breast cancer and a study on simplifying its surgical procedure.pdf

BackgroundMany breast cancer patients have avoided axillary lymph node dissection after sentinel lymph node biopsy (SLNB). During the SLNB operation, the color of lymphatic vessels is sometimes poor and so finding them is difficult. This study observed the tracing effects of three tracer combinations and also reported our experience in simplifying the SLNB program.MethodsIn total, 123 breast cancer patients whose TNM stage was cT1–2N0M0 were retrospectively studied. According to the tracer used, the patients were divided into the carbon nanoparticle (CNP) group (38 cases), CNP combined with methylene blue (CNP + MB) group (41 cases), and indocyanine green combined with MB (ICG + MB) group (44 cases). All 123 breast cancer cases were also classified into the non-tracking group (53 cases) and tracking group (70 cases) according to the SLNB operation process. The non-tracking group looked for the stained sentinel lymph nodes directly, while the tracking group looked for the stained lymph nodes along the lymphatic vessels.ResultsThe SLN identification rates in the CNP, CNP + MB, and ICG + MB groups were 97.4%, 97.6%, and 95.5% respectively (P > 0.05). The average number of SLNs detected was 4.92 ± 2.06, 5.12 ± 2.18, and 4.57 ± 1.90, respectively (P > 0.05). The ideal display rates of lymphatic vessels in the three groups were 86.8%, 87.8%, and 93.2%, respectively (P > 0.05). The SLN identification rates in the non-tracking and tracking groups were 96.2% and 97.1%, respectively (P > 0.05). The average number of SLNs detected were 5.73 ± 1.76 and 5.70 ± 1.93, respectively (P > 0.05), and the average operation time was 16.47 ± 5.78 and 27.53 ± 7.75 min, respectively (P ConclusionThis is the first study to observe the application effect of CNP combined with MB and ICG combined with MB tracers in SLNB of breast cancer patients. No significant difference was observed among the patients in SLN identification and lymphatic vessel display. Omitting the step of searching for lymphatic vessels in SLNB surgery does not reduce the surgical effect, but the reduced operating steps can reduce the surgical time and theoretically reduce postoperative complications.</p

Post-stroke cognition with the Oxford Cognitive Screen versus Montreal Cognitive Assessment: a multi-site randomized controlled study (OCS-CARE): CONSORT checklist

CONSORT checklist to go along with the AMCR manuscript titled 'Post-stroke cognition with the Oxford Cognitive Screen versus Montreal Cognitive Assessment: a multi-site randomized controlled study (OCS-CARE)'<br

A Combinatorial Library of Unsaturated Lipidoids for Efficient Intracellular Gene Delivery

A combinatorial library of unsaturated lipidoids was synthesized through the Michael addition of amines to oleyl acrylamide. Their capability in facilitating in vitro gene delivery was evaluated by transfecting HeLa cells with EGFP-encoding plasmid DNA and mRNA. The preliminary screening results indicated that lipidoids with unsaturated oleyl tails are superior transfection agents compared to saturated lipidoids with <i>n</i>-octadecyl tails under the same conditions. The different transfection abilities of the unsaturated and saturated lipidioids were ascribed to the large, tightly packed lipoplexes of saturated lipidoids. The potential applications of the library of lipidoids were further expanded by looking at their ability to transfect fibroblasts as well as different cancerous cell lines

Quantum Photonic Circuits Integrated with Color Centers in Designer Nanodiamonds

Diamond has emerged as a leading host material for solid-state quantum emitters, quantum memories, and quantum sensors. However, the challenges in fabricating photonic devices in diamond have limited its potential for use in quantum technologies. While various hybrid integration approaches have been developed for coupling diamond color centers with photonic devices defined in a heterogeneous material, these methods suffer from either large insertion loss at the material interface or evanescent light-matter coupling. Here, we present a new technique that enables the deterministic assembly of diamond color centers in a silicon nitride photonic circuit. Using this technique, we observe Purcell enhancement of silicon vacancy centers coupled to a silicon nitride ring resonator. Our hybrid integration approach has the potential for achieving the maximum possible light-matter interaction strength while maintaining low insertion loss and paves the way toward scalable manufacturing of large-scale quantum photonic circuits integrated with high-quality quantum emitters and spins

Characterization of Optical and Spin Properties of Single Tin-Vacancy Centers in Diamond Nanopillars

Color centers in diamond have attracted much interest as candidates for optically active, solid-state quantum bits. Of particular interest are inversion-symmetric color centers based on group-IV impurities in diamond because they emit strongly into their zero-phonon lines and are insensitive to electric field noise to first order. Early studies of the negatively-charged tin-vacancy (SnV$^{-}$) center in diamond have found the SnV$^{-}$ to be a promising candidate: it has high quantum efficiency, emits strongly into its zero-phonon lines, and is expected to have a long $T_2$ spin coherence time at 4~K. To develop the SnV$^{-}$ into a spin qubit requires further characterization, especially of the spin and optical properties of individual SnV$^{-}$ in nanofabricated structures. In this work we isolate single SnV$^{-}$ centers in diamond nanopillars and characterize their emission properties and their spin response to a magnetic field. We observe narrow emission linewidths that are spectrometer-limited, as well as a strong polarization dependence of each transition. We also find the Zeeman splitting under a magnetic field to be in good agreement with theoretical prediction. Our results pave the way toward future employment of single SnV$^{-}$s for optically accessible quantum memories

Table_3_Influence of Water Temperature and Flow Velocity on Locomotion Behavior in Tropical Commercially Important Sea Cucumber Stichopus monotuberculatus.xlsx

Sea cucumber Stichopus monotuberculatus is one species of tropical sea cucumbers with high recognition and economic value. While advances have been made in the nursery rearing of the sea cucumber, influence of environmental factors on its locomotion behavior remains less understood, which restricts the establishment of mariculture technologies. In the present study, locomotion behavior of S. monotuberculatus under different temperatures and flow velocities were examined through controlled simulation experiments. Results showed that the creeping activities were obviously affected by temperature, and the most active movement and feeding behavior were recorded at relatively high temperatures. Diurnal variation of locomotion and feeding activities indicated that S. monotuberculatus displayed an evident nocturnal activity pattern, being the most active at night, exhibiting intermediate activity at dusk, and minimal activity during the daytime. The movement velocity decreased with the increasing flow speed and was only 1.65 ± 1.35cm·min-1 in the highest flow rate group (20.8 ± 3.4cm/s). Moreover, the sea cucumber S. monotuberculatus displayed positive rheotaxis behavior of moving downstream at all flow velocities. Overall, the sea cucumber S. monotuberculatus exhibited high locomotor and feeding activities at night of relatively high temperature, and its favoured flow regime was downstream and low water velocity area. These findings may assist the sea ranching and aquaculture development of the tropical commercial sea cucumber species.</p

sj-docx-6-hss-10.1177_15563316221145688 – Supplemental material for Comparison of Perioperative Outcomes and Early Complications Between a Direct Anterior Approach or Posterolateral Approach in Simultaneous Bilateral Total Hip Arthroplasty: A Retrospective Study

Supplemental material, sj-docx-6-hss-10.1177_15563316221145688 for Comparison of Perioperative Outcomes and Early Complications Between a Direct Anterior Approach or Posterolateral Approach in Simultaneous Bilateral Total Hip Arthroplasty: A Retrospective Study by Liyile Chen, Shuo Sun, Qiuru Wang, Aergen Bahete, Lijun Cai and Pengde Kang in HSS Journal®: The Musculoskeletal Journal of Hospital for Special Surgery</p

sj-docx-4-hss-10.1177_15563316221145688 – Supplemental material for Comparison of Perioperative Outcomes and Early Complications Between a Direct Anterior Approach or Posterolateral Approach in Simultaneous Bilateral Total Hip Arthroplasty: A Retrospective Study

Supplemental material, sj-docx-4-hss-10.1177_15563316221145688 for Comparison of Perioperative Outcomes and Early Complications Between a Direct Anterior Approach or Posterolateral Approach in Simultaneous Bilateral Total Hip Arthroplasty: A Retrospective Study by Liyile Chen, Shuo Sun, Qiuru Wang, Aergen Bahete, Lijun Cai and Pengde Kang in HSS Journal®: The Musculoskeletal Journal of Hospital for Special Surgery</p

Table_2_Influence of Water Temperature and Flow Velocity on Locomotion Behavior in Tropical Commercially Important Sea Cucumber Stichopus monotuberculatus.xlsx

Sea cucumber Stichopus monotuberculatus is one species of tropical sea cucumbers with high recognition and economic value. While advances have been made in the nursery rearing of the sea cucumber, influence of environmental factors on its locomotion behavior remains less understood, which restricts the establishment of mariculture technologies. In the present study, locomotion behavior of S. monotuberculatus under different temperatures and flow velocities were examined through controlled simulation experiments. Results showed that the creeping activities were obviously affected by temperature, and the most active movement and feeding behavior were recorded at relatively high temperatures. Diurnal variation of locomotion and feeding activities indicated that S. monotuberculatus displayed an evident nocturnal activity pattern, being the most active at night, exhibiting intermediate activity at dusk, and minimal activity during the daytime. The movement velocity decreased with the increasing flow speed and was only 1.65 ± 1.35cm·min-1 in the highest flow rate group (20.8 ± 3.4cm/s). Moreover, the sea cucumber S. monotuberculatus displayed positive rheotaxis behavior of moving downstream at all flow velocities. Overall, the sea cucumber S. monotuberculatus exhibited high locomotor and feeding activities at night of relatively high temperature, and its favoured flow regime was downstream and low water velocity area. These findings may assist the sea ranching and aquaculture development of the tropical commercial sea cucumber species.</p

A single-photon switch and transistor enabled by a solid-state quantum memory

Single-photon switches and transistors generate strong photon-photon interactions that are essential for quantum circuits and networks. However, to deterministically control an optical signal with a single photon requires strong interactions with a quantum memory, which have been lacking in a solid-state platform. We realize a single-photon switch and transistor enabled by a solid-state quantum memory. Our device consists of a semiconductor spin qubit strongly coupled to a nanophotonic cavity. The spin qubit enables a single gate photon to switch a signal field containing up to an average of 27.7 photons, with a switching time of 63 ps. Our results show that semiconductor nanophotonic devices can produce strong and controlled photon-photon interactions that could enable high-bandwidth photonic quantum information processing