An Analysis on Syntactic and Semantic Factors Found in Newspaper Headlines

As a type of media text, newspaper has an important role in human\u27s life because it presents various local, national and International information and events. In order to attract readers\u27 attention, journalists make the headlines as ambiguous and confusing as possible so that readers are curious to know the content of the whole story and they would read it. Moreover, in presenting the information or events, different reporters will have different linguistic choices which include the choice of words and expressions and different linguistic structures. Thus, this paper analyzes how the different linguistic choices and structures used in the headlines of The Jakarta Post and Indonesian Daily News would construct different linguistic representations of events in the world

Numerical Study on Droplet Sliding across Micropillars

Droplet sliding on surfaces is an important phenomenon since it widely happens in microfluidic industry. In this article, we simulate droplets sliding across micropillars on smooth substrates to test how the pillars with different intrinsic wettability influence the movement of droplets. The simulation is performed using a particle-based numerical method, many-body dissipative particle dynamics (MDPD). The simulated results show that the heterogeneous area (built by arranged micropillars) can influence the dynamical contact angles significantly. Both the advancing and receding contact angles increase when the droplet front slides on the heterogeneous area, and their difference is also enlarged, thus the contact line may be pinned. The droplet shows a creeping motion style when its front climbs over each pillar. We also find when the droplet enwraps all pillars, the composite liquid/solid surfaces have no effect on the advancing and receding contact angles. The outcomes support the viewpoint that the wettability is a contact-line-based problem instead of a contact-area-based one

Genetic Incorporation of a 2‑Naphthol Group into Proteins for Site-Specific Azo Coupling

The 2-naphthol analogue of tyrosine, 2-amino-3-(6-hydroxy-2-naphthyl)­propanoic acid (NpOH), has been genetically introduced into proteins in Escherichia coli. This is achieved through the directed evolution of orthogonal aminoacyl-tRNA synthetase/tRNA pairs that selectively charge the target amino acid in response to the amber stop codon, UAG. Moreover, chemoselective azo coupling reactions have been revealed between the 2-naphthol group and diazotized aniline derivatives that are substituted with an electron donating moiety. The coupling reactions required a very mild condition (pH 7) with great reaction rate (less than 2 h at 0 °C), high efficiency, and excellent selectivity

Covariance Matrix Estimation for High-Throughput Biomedical Data with Interconnected Communities

Estimating a covariance matrix is central to high-dimensional data analysis. Empirical analyses of high-dimensional biomedical data, including genomics, proteomics, microbiome, and neuroimaging, among others, consistently reveal strong modularity in the dependence patterns. In these analyses, intercorrelated high-dimensional biomedical features often form communities or modules that can be interconnected with others. While the interconnected community structure has been extensively studied in biomedical research (e.g., gene co-expression networks), its potential to assist in the estimation of covariance matrices remains largely unexplored. To address this gap, we propose a procedure that leverages the commonly observed interconnected community structure in high-dimensional biomedical data to estimate large covariance and precision matrices. We derive the uniformly minimum variance unbiased estimators for covariance and precision matrices in closed forms and provide theoretical results on their asymptotic properties. Our proposed method enhances the accuracy of covariance- and precision-matrix estimation and demonstrates superior performance compared to the competing methods in both simulations and real data analyses.</p

sj-docx-1-arp-10.1177_02750740231185849 - Supplemental material for In the Shadow of Administrative Decentralization: The Impact of Devolution on Subnational Service Provision

Supplemental material, sj-docx-1-arp-10.1177_02750740231185849 for In the Shadow of Administrative Decentralization: The Impact of Devolution on Subnational Service Provision by Yiran Li, Shuo Chen and Yaohui Peng in The American Review of Public Administration</p

Hybrid Cross-Linking to Construct Functional Elastomers

ConspectusElastomers have been extensively used in diverse industrial sectors such as footwear, seals, tires, and cable jacketing and have attracted more and more attention in emerging fields such as regenerative medicine, soft robotics, and stretchable electronics. Global consumption of natural and synthetic elastomers amounted to nearly 27 million metric tons in 2020. In addition, to further enhance the common properties of elastomers, it is highly desired to endow elastomers with functionalities such as reprocessability, biomimetic mechanical properties, self-healing ability, bioactivity, and electrical conductivity, which will significantly broaden their applications. The covalent or noncovalent cross-linked structure is the essential factor for the elasticity of elastomers. Traditional elastomers usually comprise a single type of cross-linked molecular network, for which it is difficult to modulate the properties and introduce functionalities. Inspired by the simultaneous existence of multiple cross-linked structures in proteins, researchers have employed a hybrid cross-linking strategy to construct elastomers. Various noncovalent interactions (e.g., hydrogen bonds, metal–ligand coordination, ionic interactions, and chain folding) and dynamic covalent bonds (e.g., disulfide bonds, oxime–urethane bonds, and urea bonds) have been integrated in elastomers. Accordingly, the properties and functionalities of elastomers can be tuned by regulating the types, ratios, and distributions of cross-links. The hybrid cross-linking strategy provides a versatile and effective way to construct diverse functional elastomers for broad applications in various important fields.In this Account, we present our recent progress on functional elastomers constructed by a hybrid cross-linking strategy, including their design, preparation, properties, and diverse applications. First, we provide a brief introduction of the basic concept of functional elastomers and outline general strategies and mechanics for functional elastomers constructed by hybrid cross-linking. Then, we classify hybrid cross-linked elastomers by their design strategies, including multiple cross-linking, topological design, chemical coupling, and multiple networks. The relationships between the functionalities and hybrid cross-linked structures are summarized. At the same time, we also introduce diverse applications of these hybrid cross-linked elastomers in biomedicine, flexible electronics, soft robotics, 3D printing, and so on. Finally, we discuss our perspective on open challenges and future development trends of this rapidly evolving field. This Account highlighting the diverse hybrid cross-linked elastomers not only provides insights into strategies for elastomer functionalization but also provides new ideas for material design and inspires a variety of new applications

Additional file 1 of ALKBH5-mediated m6A demethylation of lncRNA PVT1 plays an oncogenic role in osteosarcoma

Additional file 1: Figure S1. The 19 RRACH motifs within PVT1 transcript

Modification of Crystal-Optimized TiO₂ with Biomass-Derived Carbon Quantum Dots for Highly Efficient Degradation of Favipiravir in Water

TiO2 has been extensively used in the photocatalytic degradation of diverse organic pollutants; however, the wide band gap and high recombination of photogenerated electrons and holes severely limit its practical application. Herein, we propose a novel and cost-effective approach for synthesizing a highly efficient TiO2-based photocatalyst by modifying crystalline phase-optimized TiO2 (with a rutile ratio of 78.5%) with blue algae-derived carbon quantum dots (B-CQDs). The as-synthesized photocatalyst (BCQD@TiO2–700) can activate peroxymonosulfate to degrade 98.6% of the COVID-19 drug favipiravir within 60 min (k = 0.0438 min–1), which was approximately 10 times that of B-CQD-modified TiO2 and 16 times that of conventional organic-derived CQD-modified TiO2–700. The abundant functional groups (−OH, CO, C–O–C, P–O, etc.) and narrow average particle size (only 1.42 nm) of the B-CQDs, as well as the optimized rutile ratio, are the main reasons for the improved reactivity of BCQD@TiO2–700. The nonradical degradation process with 1O2 as the main active species dominates favipiravir degradation, which includes the removal of substituents (–F/–NH2) and the opening of a nitrogen heterocyclic ring; these findings are also supported by density functional theory quantum chemical calculations. This work presents a cost-effective TiO2-based photocatalyst for the high-efficiency degradation of emerging organic pollutants

Efficient Electrochemical Reduction of Carbon Dioxide to Acetate on Nitrogen-Doped Nanodiamond

Electrochemical reduction of CO₂ is an attractive technique for reducing CO₂ emission and converting it into useful chemicals, but it suffers from high overpotential, low efficiency or poor product selectivity. Here, N-doped nanodiamond/Si rod array (NDD/Si RA) was proposed as an efficient nonmetallic electrocatalyst for CO₂ reduction. It preferentially and rapidly converted CO₂ to acetate over formate with an onset potential of −0.36 V (vs RHE), overcoming the usual limitation of low selectivity for C2 products. Moreover, faradic efficiency of 91.2–91.8% has been achieved for CO₂ reduction at −0.8 to −1.0 V. Its superior performance for CO₂ reduction can be attributed to its high overpotential for hydrogen evolution and N doping, where N-sp³C species was highly active for CO₂ reduction. Electrokinetic data and <i>in situ</i> infrared spectrum revealed the main pathway for CO₂ reduction might be CO₂ → CO₂^•– → (COO)₂^• → CH₃COO^–

Immunocytochemical localization of NHE1 in CHO and AP1 cells.

Upper row, CHO cells which contain their own endogenous NHE1 protein. Bottom row, AP1 cells (that do not have an endogenous NHE1 protein) that were stably transfected with the 735 stop NHE1 protein. Column 1, DAPI staining of cells. Column 2, cells were reacted with anti-NHE1 antibody that reacts with the distal region of the NHE1 cytosolic tail. Column 3, merge of the images of the first two columns. Anti-NHE1 protein reacts with the endogenous, full length NHE1 protein present in wild type CHO cells. There was no signal in the AP1 cells transfected with the 735 stop NHE1 protein. AP1 cells have no endogenous NHE1 protein. Since the 735 stop NHE1 protein is shortened, the monoclonal anti NHE1 antibody site is absent and the antibody does not react with the 735 stop protein. (PDF)</p