Table_3_Gut microbiome predicts selenium supplementation efficiency across different Chinese adult cohorts using hybrid modeling and feature refining.XLSX

Selenium (Se) is an essential trace element that plays a vital role in various physiological functions of the human body, despite its small proportion. Due to the inability of the human body to synthesize selenium, there has been increasing concern regarding its nutritional value and adequate intake as a micronutrient. The efficiency of selenium absorption varies depending on individual biochemical characteristics and living environments, underscoring the importance of accurately estimating absorption efficiency to prevent excessive or inadequate intake. As a crucial digestive organ in the human body, gut harbors a complex and diverse microbiome, which has been found to have a significant correlation with the host’s overall health status. To investigate the relationship between the gut microbiome and selenium absorption, a two-month intervention experiment was conducted among Chinese adult cohorts. Results indicated that selenium supplementation had minimal impact on the overall diversity of the gut microbiome but was associated with specific subsets of microorganisms. More importantly, these dynamics exhibited variations across regions and sequencing batches, which complicated the interpretation and utilization of gut microbiome data. To address these challenges, we proposed a hybrid predictive modeling method, utilizing refined gut microbiome features and host variable encoding. This approach accurately predicts individual selenium absorption efficiency by revealing hidden microbial patterns while minimizing differences in sequencing data across batches and regions. These efforts provide new insights into the interaction between micronutrients and the gut microbiome, as well as a promising direction for precise nutrition in the future.</p

Table_4_Gut microbiome predicts selenium supplementation efficiency across different Chinese adult cohorts using hybrid modeling and feature refining.XLSX

Selenium (Se) is an essential trace element that plays a vital role in various physiological functions of the human body, despite its small proportion. Due to the inability of the human body to synthesize selenium, there has been increasing concern regarding its nutritional value and adequate intake as a micronutrient. The efficiency of selenium absorption varies depending on individual biochemical characteristics and living environments, underscoring the importance of accurately estimating absorption efficiency to prevent excessive or inadequate intake. As a crucial digestive organ in the human body, gut harbors a complex and diverse microbiome, which has been found to have a significant correlation with the host’s overall health status. To investigate the relationship between the gut microbiome and selenium absorption, a two-month intervention experiment was conducted among Chinese adult cohorts. Results indicated that selenium supplementation had minimal impact on the overall diversity of the gut microbiome but was associated with specific subsets of microorganisms. More importantly, these dynamics exhibited variations across regions and sequencing batches, which complicated the interpretation and utilization of gut microbiome data. To address these challenges, we proposed a hybrid predictive modeling method, utilizing refined gut microbiome features and host variable encoding. This approach accurately predicts individual selenium absorption efficiency by revealing hidden microbial patterns while minimizing differences in sequencing data across batches and regions. These efforts provide new insights into the interaction between micronutrients and the gut microbiome, as well as a promising direction for precise nutrition in the future.</p

Table_2_Gut microbiome predicts selenium supplementation efficiency across different Chinese adult cohorts using hybrid modeling and feature refining.XLSX

Selenium (Se) is an essential trace element that plays a vital role in various physiological functions of the human body, despite its small proportion. Due to the inability of the human body to synthesize selenium, there has been increasing concern regarding its nutritional value and adequate intake as a micronutrient. The efficiency of selenium absorption varies depending on individual biochemical characteristics and living environments, underscoring the importance of accurately estimating absorption efficiency to prevent excessive or inadequate intake. As a crucial digestive organ in the human body, gut harbors a complex and diverse microbiome, which has been found to have a significant correlation with the host’s overall health status. To investigate the relationship between the gut microbiome and selenium absorption, a two-month intervention experiment was conducted among Chinese adult cohorts. Results indicated that selenium supplementation had minimal impact on the overall diversity of the gut microbiome but was associated with specific subsets of microorganisms. More importantly, these dynamics exhibited variations across regions and sequencing batches, which complicated the interpretation and utilization of gut microbiome data. To address these challenges, we proposed a hybrid predictive modeling method, utilizing refined gut microbiome features and host variable encoding. This approach accurately predicts individual selenium absorption efficiency by revealing hidden microbial patterns while minimizing differences in sequencing data across batches and regions. These efforts provide new insights into the interaction between micronutrients and the gut microbiome, as well as a promising direction for precise nutrition in the future.</p

Table_1_Gut microbiome predicts selenium supplementation efficiency across different Chinese adult cohorts using hybrid modeling and feature refining.DOCX

Selenium (Se) is an essential trace element that plays a vital role in various physiological functions of the human body, despite its small proportion. Due to the inability of the human body to synthesize selenium, there has been increasing concern regarding its nutritional value and adequate intake as a micronutrient. The efficiency of selenium absorption varies depending on individual biochemical characteristics and living environments, underscoring the importance of accurately estimating absorption efficiency to prevent excessive or inadequate intake. As a crucial digestive organ in the human body, gut harbors a complex and diverse microbiome, which has been found to have a significant correlation with the host’s overall health status. To investigate the relationship between the gut microbiome and selenium absorption, a two-month intervention experiment was conducted among Chinese adult cohorts. Results indicated that selenium supplementation had minimal impact on the overall diversity of the gut microbiome but was associated with specific subsets of microorganisms. More importantly, these dynamics exhibited variations across regions and sequencing batches, which complicated the interpretation and utilization of gut microbiome data. To address these challenges, we proposed a hybrid predictive modeling method, utilizing refined gut microbiome features and host variable encoding. This approach accurately predicts individual selenium absorption efficiency by revealing hidden microbial patterns while minimizing differences in sequencing data across batches and regions. These efforts provide new insights into the interaction between micronutrients and the gut microbiome, as well as a promising direction for precise nutrition in the future.</p

Network Propagation with Dual Flow for Gene Prioritization

<div><p>Based on the hypothesis that the neighbors of disease genes trend to cause similar diseases, network-based methods for disease prediction have received increasing attention. Taking full advantage of network structure, the performance of global distance measurements is generally superior to local distance measurements. However, some problems exist in the global distance measurements. For example, global distance measurements may mistake non-disease hub proteins that have dense interactions with known disease proteins for potential disease proteins. To find a new method to avoid the aforementioned problem, we analyzed the differences between disease proteins and other proteins by using essential proteins (proteins encoded by essential genes) as references. We find that disease proteins are not well connected with essential proteins in the protein interaction networks. Based on this new finding, we proposed a novel strategy for gene prioritization based on protein interaction networks. We allocated positive flow to disease genes and negative flow to essential genes, and adopted network propagation for gene prioritization. Experimental results on 110 diseases verified the effectiveness and potential of the proposed method.</p></div

Networks used in this work.

<p>Networks used in this work.</p

An example of gene prioritization based on network.

<p>(a) The disease proteins <i>a</i> and <i>b</i> are selected as the training set, while <i>c</i> as the test disease protein. (b) Global distance measurements may mistake the non-disease hub protein <i>e</i> for a disease protein.</p

Median values of the proportions of non-disease essential proteins among <i>n</i> (<i>n</i> ∈ {1, 2, 3, 4, 5, 6}) neighbors of nonessential disease proteins (<i>D</i>⁻) and other proteins (<i>O</i>) in the protein interaction network constructed based on the i2d database.

<p>Median values of the proportions of non-disease essential proteins among <i>n</i> (<i>n</i> ∈ {1, 2, 3, 4, 5, 6}) neighbors of nonessential disease proteins (<i>D</i>⁻) and other proteins (<i>O</i>) in the protein interaction network constructed based on the i2d database.</p

Leukoencephalopathy with Vanishing White Matter Protein-Protein Interaction Network.

<p>Leukoencephalopathy with Vanishing White Matter Protein-Protein Interaction Network.</p

ROC curves.

<p>ROC curves.</p