Supplementary Figure 1 from TFF2–CXCR4 Axis Is Associated with <i>BRAF</i> V600E Colon Cancer

Supplementary Figure 1. Normalized TFF2 mRNA expression vs. phospho-ERK1/2 protein levels in BRAF WT tumors.</p

Supplementary Figure Legend from TFF2–CXCR4 Axis Is Associated with <i>BRAF</i> V600E Colon Cancer

Supplementary Figure Legend.</p

Supplementary Table 1 from TFF2–CXCR4 Axis Is Associated with <i>BRAF</i> V600E Colon Cancer

Supplementary Table 1. Natural language processing results to identify senescence suppressors that are two-fold overexpressed in sessile serrated polyps.</p

Distribution of MSI-L/MSS colorectal cancers according to the number of methylated promoters

<p><b>Copyright information:</b></p><p>Taken from "18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high"</p><p>http://www.biomedcentral.com/1471-2407/7/72</p><p>BMC Cancer 2007;7():72-72.</p><p>Published online 2 May 2007</p><p>PMCID:PMC1876238.</p><p></p> The X and Y axes indicate the number of methylated promoters and the number of tumors, respectively. Based on the and mutation rates, CIMP-high is defined as the presence of ≥ 6/8 methylated promoters. Also note that CIMP-0 tumors with 0/8 methylated promoters are more likely to have both wild-type and , compared to CIMP-low tumors with 1/8 to 5/8 methylated promoters. Abbreviations: BRAF+, -mutated wild-type; KRAS+, -mutated wild-type; K+/B+, -mutated -mutated; KRAS/BRAF WT, both wild-type and ; MSI-L, microsatellite instability-low; MSS, microsatellite stable

Baseline characteristics of the Nurses' Health Study cohort^*.

<p>*Dietary intake and other characteristics at baseline questionnaire in 1980 (mean value, unless otherwise indicated).</p>Ψ<p>All values have been directly standardized according to the age distribution of the cohort.</p>†<p>Pack-years were calculated for former and current smokers only.</p>‡<p>The body-mass index is the weight in kilograms divided by the square of the height in meters.</p>§<p>METS are metabolic equivalents. This was calculated based on the frequency of physical activities (such as jogging) in 1986.</p

Risk of colon cancer according to baseline quintiles of one-carbon nutrient intake by BRAF mutation status in tumors among 88,691 women in the Nurses' Health Study (1980–2002).

‡<p>Age adjusted only.</p><p>*All models are adjusted for age (continuous), energy intake, gender, screening sigmoidoscopy, family history of colorectal cancer, aspirin use, smoking, physical activity in METs, baseline body mass index, a history of colon polyps, beef intake, calcium, multi-vitamin use, and baseline folate, vitamin B₆, B₁₂, methionine, and alcohol if not primary exposure.</p

Frequency of 18q LOH in MSI-L/MSS colorectal cancers, according to the number of methylated promoters

<p><b>Copyright information:</b></p><p>Taken from "18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high"</p><p>http://www.biomedcentral.com/1471-2407/7/72</p><p>BMC Cancer 2007;7():72-72.</p><p>Published online 2 May 2007</p><p>PMCID:PMC1876238.</p><p></p> CIMP-0 tumors (N = 200) with 0 methylated promoters show the highest frequency of 18q LOH

Risk of colon cancer according to baseline quintiles of one-carbon nutrient intake by CIMP expression in tumors among 88,691 women in the Nurses' Health Study (1980–2002).

‡<p>Age adjusted only.</p><p>*All models are adjusted for age (continuous), energy intake, gender, screening sigmoidoscopy, family history of colorectal cancer, aspirin use, smoking, physical activity in METs, baseline body mass index, a history of colon polyps, beef intake, calcium, multi-vitamin use, and baseline folate, vitamin B6, B12, methionine, and alcohol if not primary exposure. P for heterogeneity of the association for folate intake and CIMP-low/0 colon cancer versus folate intake and CIMP-high colon cancers = 0.73 (χ² = 1.31, 3 d.f.).</p><p>P for heterogeneity of the association for vitamin B₆ intake and CIMP-high colon cancer and vitamin B₆ intake and CIMP-low/0 colon cancers = 0.63 (χ² = 2.6, 4 d.f.) and for vitamin B₁₂ intake = 0.94 (χ² = 0.79, 4 d.f.). P for heterogeneity of the association for methionine intake and CIMP-high colon cancer and methionine intake and CIMP-low/0 colon cancers = 0.007 (χ² = 14.097, 4 d.f.), and for alcohol intake = 0.32 (χ² = 3.52, 3 d.f.).</p

Supplementary Methods and tables from Plasma Inflammatory Markers and Risk of Advanced Colorectal Adenoma in Women

This file contains supplementary methods on assessment of dietary and lifestyle factors, and supplementary table 1 (Stratified association of plasma MIC-1 level with risk of advanced colorectal adenomas in the Nurses' Health Study (1990-2008)).</p

Table S1 from Gene Regulatory Network Analysis Identifies Sex-Linked Differences in Colon Cancer Drug Metabolism

Extensive clinical features for the dataset included in the study.</p