13 research outputs found

    Quantitative Determination the Role of the Intrabandgap States in Water Photooxidation over Hematite Electrodes

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    The intrabandgap states on the hematite (α-Fe2O3) electrodes are believed to play an important role in water photooxidation. Yet, it is not fully understood how the intrabandgap states are involved in the reaction. In this work, the intraband-gap states in water photooxidation on α-Fe2O3 electrodes are investigated by a combination of multiple (photo-) electrochemical techniques and operando spectroscopic methods. Two kinds of surface states are observed on the electrodes during water photooxidation, and their roles are quantitatively determined by the correlation with the steady-state photocurrent. It is demonstrated that the intrinsic electronic surface state close to the conduction band can act only as the recombination center for the photocarriers. However, the photogenerated surface state closer to the valence band is revealed to be the reactant in the rate-determining step in oxygen evolution reaction. These findings may be beneficial to elucidate the actual function of the surface states and provide insights into the kinetic and mechanism studies of water photooxidation on the α-Fe2O3 electrodes

    Quantitative Determination the Role of the Intrabandgap States in Water Photooxidation over Hematite Electrodes

    No full text
    The intrabandgap states on the hematite (α-Fe2O3) electrodes are believed to play an important role in water photooxidation. Yet, it is not fully understood how the intrabandgap states are involved in the reaction. In this work, the intraband-gap states in water photooxidation on α-Fe2O3 electrodes are investigated by a combination of multiple (photo-) electrochemical techniques and operando spectroscopic methods. Two kinds of surface states are observed on the electrodes during water photooxidation, and their roles are quantitatively determined by the correlation with the steady-state photocurrent. It is demonstrated that the intrinsic electronic surface state close to the conduction band can act only as the recombination center for the photocarriers. However, the photogenerated surface state closer to the valence band is revealed to be the reactant in the rate-determining step in oxygen evolution reaction. These findings may be beneficial to elucidate the actual function of the surface states and provide insights into the kinetic and mechanism studies of water photooxidation on the α-Fe2O3 electrodes

    New Nonlinear Optical Crystal: NaBa<sub>4</sub>Al<sub>2</sub>B<sub>8</sub>O<sub>18</sub>Cl<sub>3</sub>

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    Single crystals of NaBa<sub>4</sub>Al<sub>2</sub>B<sub>8</sub>O<sub>18</sub>Cl<sub>3</sub> have been grown with sizes up to 34 × 34 × 16 mm<sup>3</sup> from the NaF–LiCl flux by the top-seeded solution growth method. The compound crystallizes in the tetragonal system, space group <i>P</i>4<sub>2</sub><i>nm</i>, with <i>a</i> = 12.0480 (16) Å, <i>c</i> = 6.8165 (11) Å, α = β = γ = 90°, and two formula units per cell. The NaBa<sub>4</sub>Al<sub>2</sub>B<sub>8</sub>O<sub>18</sub>Cl<sub>3</sub> compound is built up of infinite anionic groups of [AlB<sub>4</sub>O<sub>12</sub>]<sup>9–</sup> formed by two BO<sub>4</sub> tetrahedra, one AlO<sub>4</sub> tetrahedra, and two BO<sub>3</sub> triangles. Optical properties including ultraviolet transmission, IR spectrum, and second-harmonic generation of NaBa<sub>4</sub>Al<sub>2</sub>B<sub>8</sub>O<sub>18</sub>Cl<sub>3</sub> crystals were reported. Refractive indices were measured by the minimum deviation technique and fitted to the Sellmeier equations. Thermal properties such as the DSC and thermal expansion were reported. The mechanical properties including the hardness, density, and chemical stability were also reported

    Small Molecule Survivin Inhibitor YM155 Displays Potent Activity Against Human Osteosarcoma Cells

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    <p>Survivin is an important oncogenic protein expressed highly in osteosarcoma. Here, we have shown that small molecule inhibitor YM155 potently suppressed survivin expression, inhibited cell growth, and induced apoptosis in osteosarcoma cells. Furthermore, we also showed that knock down of survivin by small interfering RNA strongly inhibited cell viability in two osteosarcoma cell lines, suggesting that suppression of survivin essentially contributes to YM155-mediated anticancer activity in osteosarcoma cells. Collectively, our study suggests that YM155 holds promise for patients with osteosarcoma.</p

    New Nonlinear Optical Crystal: NaBa<sub>4</sub>Al<sub>2</sub>B<sub>8</sub>O<sub>18</sub>Cl<sub>3</sub>

    No full text
    Single crystals of NaBa<sub>4</sub>Al<sub>2</sub>B<sub>8</sub>O<sub>18</sub>Cl<sub>3</sub> have been grown with sizes up to 34 × 34 × 16 mm<sup>3</sup> from the NaF–LiCl flux by the top-seeded solution growth method. The compound crystallizes in the tetragonal system, space group <i>P</i>4<sub>2</sub><i>nm</i>, with <i>a</i> = 12.0480 (16) Å, <i>c</i> = 6.8165 (11) Å, α = β = γ = 90°, and two formula units per cell. The NaBa<sub>4</sub>Al<sub>2</sub>B<sub>8</sub>O<sub>18</sub>Cl<sub>3</sub> compound is built up of infinite anionic groups of [AlB<sub>4</sub>O<sub>12</sub>]<sup>9–</sup> formed by two BO<sub>4</sub> tetrahedra, one AlO<sub>4</sub> tetrahedra, and two BO<sub>3</sub> triangles. Optical properties including ultraviolet transmission, IR spectrum, and second-harmonic generation of NaBa<sub>4</sub>Al<sub>2</sub>B<sub>8</sub>O<sub>18</sub>Cl<sub>3</sub> crystals were reported. Refractive indices were measured by the minimum deviation technique and fitted to the Sellmeier equations. Thermal properties such as the DSC and thermal expansion were reported. The mechanical properties including the hardness, density, and chemical stability were also reported

    Table_1_Induction chemoimmunotherapy may improve outcomes of chemoradiotherapy in patients with unresectable stage III NSCLC.docx

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    BackgroundCurrently, the value of induction chemoimmunotherapy before chemoradiotherapy (CRT) in unresectable stage III non-small cell lung cancer (NSCLC) has not been explored. This study was designed to explore the efficacy and safety of induction chemoimmunotherapy in patients with unresectable stage III NSCLC.MethodsUnresectable stage III NSCLC patients who received CRT with or without induction chemoimmunotherapy between August 2014 and December 2021 were retrospectively enrolled. Progression-free survival (PFS) and overall survival (OS) were assessed from the initiation of treatment and estimated by the Kaplan-Meier method. The potential factors affecting PFS and OS were analyzed by univariate and multivariate Cox regression models. One-to-one propensity score matching (PSM) was used to further minimize confounding.ResultsA total of 279 consecutive patients were enrolled, with 53 (19.0%) receiving induction chemoimmunotherapy followed by CRT (I-CRT group), and the remaining 226 (81.0%) receiving CRT alone (CRT group). After PSM, the median PFS was 24.8 months in the I-CRT group vs. 13.3 months in the CRT group (P=0.035). The median OS was not reached (NR) vs. 36.6 months ((P=0.142). The incidence of treatment-related adverse events (TRAEs) was similar in both groups, except that the incidence of hematological toxicity was higher in the I-CRT group (77.1% vs. 58.3%, P=0.049). Compared to induction chemotherapy, induction chemoimmunotherapy demonstrated a superior objective response rate (60.4% vs. 22.2%, PConclusionInduction chemoimmunotherapy is safe and may improve outcomes of CRT in patients with unresectable stage III NSCLC. Moreover, induction chemoimmunotherapy may further improve treatment response and survival outcomes compared to induction chemotherapy before cCRT.</p

    Odd ratios (OR) for ICAS according to baseline blood lipid levels quintiles.

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    <p>95% CI, 95% confidence interval; non-HDL-C, non-high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol.</p>*<p>Model 1: adjusted for age, and gender. <sup>†</sup>Model2: adjusted for age, gender, BMI, hypertension, diabetes, smoking, HDL-C and triglycerides.</p
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