Nickel-Catalyzed Enantioselective Reductive Arylation of Common Ketones

A nickel complex of chiral bisoxazolines catalyzed the stereoselective reductive arylation of ketones in high enantioselectivity. A range of common acyclic and cyclic ketones reacted without the aid of directing groups. Mechanistic studies using isolated complex of a chiral bis(oxazoline) (L)Ni(Ar)Br revealed that Mn reduction was not needed, while Lewis acidic titanium alkoxides were critical to ketone insertion

Nickel-Catalyzed Enantioselective Reductive Arylation of Common Ketones

A nickel complex of chiral bisoxazolines catalyzed the stereoselective reductive arylation of ketones in high enantioselectivity. A range of common acyclic and cyclic ketones reacted without the aid of directing groups. Mechanistic studies using isolated complex of a chiral bis(oxazoline) (L)Ni(Ar)Br revealed that Mn reduction was not needed, while Lewis acidic titanium alkoxides were critical to ketone insertion

Additional file 1 of Understanding the complexity of sepsis mortality prediction via rule discovery and analysis: a pilot study

Additional file 1. The remaining 67 rules

Subgroup analysis of the association between circulating Nrg4 levels and DM.

Subgroup analysis of the association between circulating Nrg4 levels and DM.</p

Forest plot of the association between circulation Nrg4 levels and renal function markers in DM.

Summaries are shown of the association circulation Nrg4 levels and (A) eGFR and (B) creatinine.</p

Additional file 2 of Understanding the complexity of sepsis mortality prediction via rule discovery and analysis: a pilot study

Additional file 2. TRIPOD Checklist for prediction model development and validation with added text excerpts or remarks

Forest plot of the association between circulation Nrg4 levels and DM; RE Model, random-effect model.

Forest plot of the association between circulation Nrg4 levels and DM; RE Model, random-effect model.</p

Forest plot of the association between circulation Nrg4 levels and obesity markers in DM.

Summaries are shown of the association circulation Nrg4 levels and (A) BMI and (B) WC.</p

Forest plot of the association between circulation Nrg4 levels and diabetes markers in DM.

Summaries are shown of the association circulation Nrg4 levels and (A) FPG, (B) HOMA-IR and (C) HbA1c; FE Model, fixed-effect model.</p