Construction of Functionalized Annulated Sulfone via SO₂/I Exchange of Cyclic Diaryliodonium Salts

A straightforward protocol for diarylannulated sulfone construction is efficiently established via SO₂/I exchange of iodonium­(III) salts. Readily available inorganic Na₂S₂O₅ was served as a safe and convenient SO₂ surrogate. Diverse functionalized diarylannulated sulfones were smoothly achieved in good to excellent yields with great functional group compatibility. Organic light emitting diodes (OLEDs) material molecules were subsequently established via this method in gram scale. The unsymmetrical conjugated systems with donor-acceptor groups and π-conjugation bridges motifs, which substantially communicate electron mobility in semiconductor material molecules, were successfully afforded under the facile conditions of the exchange strategy

Construction of Functionalized Annulated Sulfone via SO₂/I Exchange of Cyclic Diaryliodonium Salts

A straightforward protocol for diarylannulated sulfone construction is efficiently established via SO₂/I exchange of iodonium­(III) salts. Readily available inorganic Na₂S₂O₅ was served as a safe and convenient SO₂ surrogate. Diverse functionalized diarylannulated sulfones were smoothly achieved in good to excellent yields with great functional group compatibility. Organic light emitting diodes (OLEDs) material molecules were subsequently established via this method in gram scale. The unsymmetrical conjugated systems with donor-acceptor groups and π-conjugation bridges motifs, which substantially communicate electron mobility in semiconductor material molecules, were successfully afforded under the facile conditions of the exchange strategy

Construction of Functionalized Annulated Sulfone via SO₂/I Exchange of Cyclic Diaryliodonium Salts

A straightforward protocol for diarylannulated sulfone construction is efficiently established via SO₂/I exchange of iodonium­(III) salts. Readily available inorganic Na₂S₂O₅ was served as a safe and convenient SO₂ surrogate. Diverse functionalized diarylannulated sulfones were smoothly achieved in good to excellent yields with great functional group compatibility. Organic light emitting diodes (OLEDs) material molecules were subsequently established via this method in gram scale. The unsymmetrical conjugated systems with donor-acceptor groups and π-conjugation bridges motifs, which substantially communicate electron mobility in semiconductor material molecules, were successfully afforded under the facile conditions of the exchange strategy

Construction of Functionalized Annulated Sulfone via SO₂/I Exchange of Cyclic Diaryliodonium Salts

A straightforward protocol for diarylannulated sulfone construction is efficiently established via SO₂/I exchange of iodonium­(III) salts. Readily available inorganic Na₂S₂O₅ was served as a safe and convenient SO₂ surrogate. Diverse functionalized diarylannulated sulfones were smoothly achieved in good to excellent yields with great functional group compatibility. Organic light emitting diodes (OLEDs) material molecules were subsequently established via this method in gram scale. The unsymmetrical conjugated systems with donor-acceptor groups and π-conjugation bridges motifs, which substantially communicate electron mobility in semiconductor material molecules, were successfully afforded under the facile conditions of the exchange strategy

Table1_Safety assessment of cenobamate: real-world adverse event analysis from the FAERS database.XLS

Objective:This study aims to analyze adverse drug events (ADEs) associated with cenobamate from the FAERS database, covering the third quarter of 2020 to the second quarter of 2023.Methods:Data related to cenobamate-associated ADEs from the third quarter of 2020 to the second quarter of 2023 were collected. After standardizing the data, various signal quantification techniques, including ROR, MHRA, BCPNN, and MGPS, were employed for analysis.Results:Among 2535 ADE reports where cenobamate was the primary suspected drug, 94 adverse reactions involving 11 different System Organ Class (SOC) categories were identified through the application of four signal quantification techniques. More specifically, neurological disorders and injuries resultant from complications are frequent adverse reactions associated with cenobamate.Conclusion:Our research findings align with established results, affirming the favorable safety profile of cenobamate. Effective prevention of adverse reactions induced by cenobamate can be achieved through the establishment of efficient blood concentration monitoring and dose adjustments.</p

Table2_Safety assessment of cenobamate: real-world adverse event analysis from the FAERS database.XLS

Objective:This study aims to analyze adverse drug events (ADEs) associated with cenobamate from the FAERS database, covering the third quarter of 2020 to the second quarter of 2023.Methods:Data related to cenobamate-associated ADEs from the third quarter of 2020 to the second quarter of 2023 were collected. After standardizing the data, various signal quantification techniques, including ROR, MHRA, BCPNN, and MGPS, were employed for analysis.Results:Among 2535 ADE reports where cenobamate was the primary suspected drug, 94 adverse reactions involving 11 different System Organ Class (SOC) categories were identified through the application of four signal quantification techniques. More specifically, neurological disorders and injuries resultant from complications are frequent adverse reactions associated with cenobamate.Conclusion:Our research findings align with established results, affirming the favorable safety profile of cenobamate. Effective prevention of adverse reactions induced by cenobamate can be achieved through the establishment of efficient blood concentration monitoring and dose adjustments.</p

Pre-operative corneal surface with the epithelium (green) (a), is reshaped into a regular aspheric surface of desired curvature (b) and the new surface is transferred below the epithelium (c) in a single non-interrupted ablation.

<p>Pre-operative corneal surface with the epithelium (green) (a), is reshaped into a regular aspheric surface of desired curvature (b) and the new surface is transferred below the epithelium (c) in a single non-interrupted ablation.</p

Mean wavefront aberrations 12 months after surgery and pre-operatively (6 mm zone analysis, 96 eyes).

<p>RMS: Root Mean Square; HOA: Higher Order Aberration; SD: Standard Deviation; S3+5+7: Odd Order Aberrations; S4+6+8: Even Order Aberrations.</p

Stability of spherical equivalent.

<p><b>Error bars indicate standard deviation.</b></p

Post-operative uncorrected visual acuity vs. pre-operative best spectacle-corrected visual acuity.

<p>Post-operative uncorrected visual acuity vs. pre-operative best spectacle-corrected visual acuity.</p