Diagnostic value of non-coding RNAs in ovarian cancer

The type of primary tumour of the ovary ranks first among all organs in the body. Although the incidence of malignant ovarian tumour ranks third among gynaecological malignancies, it is the most fatal type. A lack of effective diagnostic methods for early ovarian cancer remains, and the efficacy of advanced ovarian cancer is often unsatisfactory; the five-year survival rate of stage III–IV is less than 30%. Non-coding RNA is RNA that does not have protein-coding potential and was once considered as ‘junk DNA’. However, increasing number of studies have shown that the disorder of non-coding RNA is related to a variety of diseases, including the occurrence and development of tumours. We summarised the dysregulated non-coding RNAs (miRNAs, circRNAs, and lncRNAs) reported currently in ovarian cancer and their functional mechanisms, and the clinical value of different types of ncRNAs as diagnostic or predictive markers for ovarian cancer, providing further evidence for non-coding RNAs to be considered as biomarkers of ovarian cancer.</p

DHPLC shows wave pattern of wild type and mutant type <i>PKHD1</i>.

<p>Wild type: from normal individuals. Mutant type : from affected individuals.</p

Association of the IL-17 polymorphisms with serum IL-17 levels in AG patients.

The serum IL-17A and IL-17F level were measured in different genotype carriers from AG patients. A) The expression of IL-17A level was no difference between the 15 AA homozygotes, 24 AG heterozygotes carriers and 9 GG homozygotes carriers of IL-17A rs2275913 polymorphism. (P>0.05; respectively); B) The expression of IL-17F level was no difference between the 2 CC homozygotes, 14 CT heterozygotes carriers and 62 TT homozygotes carriers of IL-17F rs763780 polymorphism (P>0.05; respectively).</p

The genotypic and allelic frequencies of rs2275913, rs763780 and rs4819554 between cases and controls.

<p>The genotypic and allelic frequencies of rs2275913, rs763780 and rs4819554 between cases and controls.</p

Media 1: Pyroelectric effect in green light-assisted domain reversal of Mg-doped LiNbO₃ crystals

Originally published in Optics Express on 17 December 2012 (oe-20-27-29131

Demographic and clinical characteristics of cases and controls.

<p>Demographic and clinical characteristics of cases and controls.</p

Partial sequence of exon 24 in the <i>PKHD1</i> from member of this Caroli disease-affected pedigree.

<p>(b), (c) and (d) Arrowhead indicates the heterozygous T and C at nucleotide 2507 in proband, elder twins and their father respectively. (a) Arrowhead indicates the T at nucleotide 2507 (wild type) in their mother.</p

Multiple-sequence alignment of the PKHD1 protein including <i>Mus musculus</i>, <i>Rattus norvegicus</i>, <i>Pan paniscus</i>, <i>Xenopus (Silurana) tropicalis</i>, <i>Falco cherrug</i>, <i>Zonotrichia albicollis</i> and <i>Homo sapiens</i>.

<p>The Val 836 residue is located within a highly conserved region.</p

Media 2: Pyroelectric effect in green light-assisted domain reversal of Mg-doped LiNbO₃ crystals

Originally published in Optics Express on 17 December 2012 (oe-20-27-29131

Levels of serum IL-17A and IL-17F in the AG, IG and control groups.

<p>Serum IL-17A and IL-17F levels of 78 AG patients, 150 IG patients and 198 control subjects were detected using Elisa kit. Expression of serum IL-17A and IL-17F were significantly decreased in the AG and IG group compared with controls (P<0.001; respectively), whereas no significant difference was observed between the AG and IG groups (both P>0.05). AG represents acute gout; IG represents intercritical periods of gout. The ANOVA and Bonferroni's test methods were used. The statistical significance was set at P<0.05.</p