3D-Printed Photocurable Resin with Synergistic Hydrogen Bonding Based on Deep Eutectic Solvent

Vat polymerization, one of the 3D printing technologies, has been widely applied owing to its advantageous properties, such as high accuracy and surface quality. However, the applicability of this technology is limited to end-use product manufacturing, requiring advancements due to a gradual increase in the performance requirements and functional demands of the products. In this study, deep eutectic solvent-based photocurable resins (PCRs) with synergistic hydrogen bonding are synthesized using a facile and ecofriendly procedure to tune monomer proportions. The as-prepared PCRs, with ultralow viscosity and ultrahigh curing rate, are compatible with commercial liquid-crystal display printers. The 3D-printed parts with high optical transparency, stiffness, and thermal resistance exhibit humidity-dependent electrical conductivity and mechanical properties. In addition, the 3D-printed objects demonstrate self-healing features due to the synergistic effect of high-density hydrogen bonding in the microphase-separated polymer matrix. Moreover, different categories of structural assembly, from 2D to 3D and small to large, are demonstrated, and their solubility ensued in recycling and remolding. The synthesized PCRs are suitable for fabricating sacrificial molds, enabling the on-demand fabrication of precise multifunctional structures with various materials, which are otherwise incompatible with UV-based 3D printing, facilitating 3D printing by overcoming its material-selection limitations

Supplemental_Figure_1 - Prevalence of Workplace Violence Against Health-Care Professionals in China: A Comprehensive Meta-Analysis of Observational Surveys

<p>Supplemental_Figure_1 for Prevalence of Workplace Violence Against Health-Care Professionals in China: A Comprehensive Meta-Analysis of Observational Surveys by Li Lu, Min Dong, Shi-Bin Wang, Ling Zhang, Chee H. Ng, Gabor S. Ungvari, Jun Li, and Yu-Tao Xiang in Trauma, Violence, & Abuse</p

Overcoming Multidrug Resistance through the Synergistic Effects of Hierarchical pH-Sensitive, ROS-Generating Nanoreactors

Recently, multidrug resistance (MDR) has become a major clinical chemotherapeutic burden that robustly diminishes the intracellular drug levels through various mechanisms. To overcome the doxorubicin (Dox) resistance in tumor cells, we designed a hierarchical nanohybrid system possessing copper-substituted mesoporous silica nanoparticles (Cu-MSNs). Further, Dox was conjugated to copper metal in the Cu-MSNs framework through a pH-sensitive coordination link, which is acutely sensitive to the tumor acidic environment (pH 5.0–6.0). In the end, the nanocarrier was coated with D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS), a P-gp inhibitor-entrenched compact liposome net for obstructing the drug efflux pump. Copper ions in the framework synergize the antitumor activity of Dox by enhancing the intracellular reactive oxygen species (ROS) levels through a Fenton-like reaction-mediated conversion of hydrogen peroxide. Furthermore, intracellularly generated ROS triggered the apoptosis by reducing the cellular as well as mitochondrial membrane integrity in MDR cells, which was confirmed by the mitochondrial membrane potential (MMP) measurement. The advancement of the design and critical improvement of cytotoxic properties through free radical attack demonstrate that the proposed hierarchical design can devastate the MDR for efficient cancer treatment

Data_Sheet_1_Violent behavior and the network properties of psychopathological symptoms and real-life functioning in patients with schizophrenia.PDF

ObjectiveTo assess the interplay among psychopathological symptoms and real-life functioning, and to further detect their influence with violent behavior in patient with schizophrenia.MethodsA sample of 1,664 patients with post-violence assessments and their propensity score–matched controls without violence from a disease registration report system of community mental health service in Guangdong, China, were studied by network analysis. Ising-Model was used to estimate networks of psychopathological symptoms and real-life functioning. Then, we tested whether network properties indicated the patterns of interaction were different between cases and controls, and calculated centrality indices of each node to identify the central nodes. Sensitivity analysis was conducted to examine the difference of interaction patterns between pre-violence and post-violence assessments in violence cases.ResultsSome nodes in the same domain were highly positive interrelations, while psychopathological symptoms were negatively related to real-life functioning in all networks. Many symptom-symptom connections and symptom-functioning connections were disconnected after the violence. The network density decreased from 23.53% to 12.42% without statistical significance (p = 0.338). The network structure, the global network strength, and the global clustering coefficient decreased significantly after the violence (p ConclusionThe decreasing connectivity may indicate an increased risk of violence and early warning for detecting violence. Interventions and improving health state based on nodes with high strength might prevent violence in schizophrenia patients.</p

Supplemental material for Effect of adjunctive ranitidine for antipsychotic-induced weight gain: A systematic review of randomized placebo-controlled trials

<p>Supplemental material for Effect of adjunctive ranitidine for antipsychotic-induced weight gain: A systematic review of randomized placebo-controlled trials in Journal of International Medical Research</p

Prevalence of insomnia according to socio-demographic characteristics.

<p>Prevalence of insomnia according to socio-demographic characteristics.</p

Characteristics of studies included in the meta-analysis.

<p>Characteristics of studies included in the meta-analysis.</p

PRISMA flow diagram.

<p>PRISMA flow diagram.</p

Point prevalence of insomnia in Chinese general population.

<p>Point prevalence of insomnia in Chinese general population.</p