Down-regulation of D2R leads to the shift of synaptic plasticity from LTD to LTP in PD 30 EtOH rats.

<p>‘↑’ indicates the time point of HFS application. The hollow line represents the period of drug occurrence in ASCF. <b>A & B:</b> L-sulpiride completely blocked HFS induced LTD in control rats, but had no effect on HFS induced LTP in EtOH rats. <b>C:</b> the D2R agonist quinpirole recovered the induction of LTD in EtOH rats. <b>D & E:</b> SCH23390 completely blocked either the induction of LTD in control rats or quinpirole-recovered LTD in EtOH rats.</p

Prenatal EtOH exposure changed the postnatal synaptic plasticity at corticalstratial pathway in the DL striatum.

<p><b>A:</b> Synaptic plasticity in PD 15 control and EtOH offspring. The upper traces are the original PS waves at 15 min pre-HFS and 60 min post-HFS. Calibration bars: 0.3 mV and 4 msec. ‘↑’ indicates the time of HFS delivery. Note that HFS induced the significant potentiaton of the PS 60 min post-HFS indicative of LTP in control offspring, while did not change the PS amplitude 60 min post-HFS in EtOH offspring. <b>B&C:</b> Synaptic plasticity in PD 30–40 control and EtOH offspring. Note that HFS induced LTD in control offspring, but LTP in EtOH offspring.</p

mGluR activation mediates the quinpirole-recovered LTD in EtOH rats.

<p>‘↑’ indicates the time point of HFS application. The hollow line represents the period of drug occurrence in ASCF. <b>A & B:</b> the LTD in control rats was sensitive to MPEP, but not AP5. <b>C & D:</b> The quinpirole-recovered LTD in EtOH rats was inhibited by MPEP, but not AP5.</p