Table1_The seasonal and spatial variability of ammonium uptake in a hilly watershed.DOCX

Elevated nutrient loading can cause deleterious impacts on aquatic ecosystems such as eutrophication. Seasonal variability and land use change often lead to varied nutrient uptake from streams. However, the impacts of seasonal and spatial variation on stream nutrient transport within the same watershed haven’t been fully understood. Here, we conducted nutrient addition experiments using the Tracer Additions for Spiraling Curve Characterization (TASCC) approach within the Xiaogang Watershed, Zhejiang Province, China. Six of the experiments were conducted in one stream every other month and eight releases in eight different streams to quantify ammonium uptake kinetics across different seasons and land uses. Our findings suggest that the uptake capability increases with both discharge and ambient concentration (C0): seasonal variability of discharge shows small impacts on uptake metrics, except the ambient uptake length (Sw-amb), which increases with discharge; while the change in C0 could have more significant effects on both ambient areal uptake (Uamb) and maximum areal uptake rate parameter (Umax). Downstream the river network, the increase in discharge led to a significant increase in Uamb, ambient uptake velocity (Vf-amb), and Umax. On the other hand, the change in C0 is less influential than discharge along the river network, which may be correlated with the hydraulic geometry. Additionally, there is an optimal temperature (T) for uptake in our study region around 17°C, which may be explained by the growth of chlorophyll a. The positive correlation between Vf-amb and Q at the spatial scale may be attributed to the increase of dissolved organic carbon (DOC) and river chlorophyll a downstream with stream width. In addition, land use had an important effect on ion concentration in streams, and the proportion of agricultural land was positively correlated with nutrient concentration. Our findings could help provide scientific support for land use management and water quality regulation.</p

Efficacy and Safety of Crizotinib among Chinese EML4-ALK-Positive, Advanced-Stage Non-Small Cell Lung Cancer Patients - Figure 1

<p><b>A.</b> Overall of 40 Chinese patients treated with crizotinib. <b>B</b>. Progression free survival by different PS subgroup of 40 Chinese patients treated with crizotinib. PS, ECOG (Eastern Cooperative Oncology Group) performance status.</p

Baseline demographics of 40 Chinese patients treated with crizotinib.

<p>Baseline demographics of 40 Chinese patients treated with crizotinib.</p

Association of GPS with characteristics of patients.

<p>Association of GPS with characteristics of patients.</p

Efficacy of 40 Chinese patients treated with crizotinib according to RECIST criteria.

<p>PR: partial response; SD: stable disease; PD: progressive disease</p><p>Efficacy of 40 Chinese patients treated with crizotinib according to RECIST criteria.</p

Common side effects of 40 Chinese patients treated with crizotinib.

<p>Common side effects of 40 Chinese patients treated with crizotinib.</p

Comparison of overall survival according to scoring systems, GPS (A), NLR (B) and PLR (C).

<p>Comparison of overall survival according to scoring systems, GPS (A), NLR (B) and PLR (C).</p

A Cysteine-Maleimide-Based Design for Hemostatic, Antibacterial, and Biodegradable Wound Dressing

The field of clinical surgery frequently encounters challenges related to atypical wound tissue healing, resulting in the development of persistent chronic wounds or aesthetically displeasing scar tissue. The use of wound dressings crafted from mussel adhesive proteins and hyaluronic acid has demonstrated the potential in mitigating these undesirable outcomes. However, the synergistic effects of these two biomaterials remain underexplored. In this study, we have engineered a versatile, degradable, and biocompatible dressing that comprises recombinant 3,4-dihydroxyphenylalanine (DOPA)-modified mussel adhesive proteins and maleimide-functionalized hyaluronic acid. We have successfully fabricated this biocompatible dressing and conducted comprehensive experimental assessments to confirm its hemostatic, antibacterial, and biocompatible characteristics. Importantly, this dressing exclusively incorporates biologically derived materials characterized by low toxicity and minimal immunogenicity, thus holding immense promise for clinical applications in the field of wound healing

Additional file 1: Table S1. of Fermi Level Tuning of ZnO Films Through Supercycled Atomic Layer Deposition

Process details for one growth supercycle in the supercycled ALD process used in this study. Figure S1. Diffraction intensity ratio of the ZnO (0 0 2) peak to (1 0 1) peak as a function of O2 plasma times with fixed thermal cycle (m = 1). Figure S2. (a, d) The fitted refractive index n, (b, e) extinction coefficient k, and (c, f) plot of (αhν)2 as a function of photo energy of ZnO films grown from different O2 plasma times with fixed thermal cycle (m = 1) and different thermal cycles with fixed O2 plasma time (t 3 = 1 s) by the supercycled ALD process. Figure S3. AFM images of the supercycled ALD-grown ZnO films with O2 plasma times of (a) 0 s, (b) 1 s, (c) 2 s, (d) 4 s, and (e) 8 s and fixed thermal cycle (m = 1). Figure S4. Electronic energy levels of the tip sample system for three different cases. (a) Tip and sample are not electrically connected; (b) tip and sample are electrically connected with Fermi energy levels lined up; (c) an external bias equals to the contact potential difference V CPD is applied to the tip. Figure S5. Two-dimensional contact potential difference V CPD images of the surface potential measurements of the supercycled ALD-grown ZnO films with thermal cycles varying from (a) 2, (b) 3, and (c) 5 at fixed O2 plasma time (t 3 = 1 s). Figure S6. XPS spectra and their Gaussian fittings of the O 1s region of the supercycled ALD-grown ZnO films with thermal cycles varying from (a) 2, (b) 3, and (c) 5 at fixed O2 plasma time (t 3 = 1 s). (DOCX 1919 kb

Comparisons of the area under the receiver operating curve for survival status between scoring systems at 6 month (A), 12 month (B) and 24 month (C).

<p>Comparisons of the area under the receiver operating curve for survival status between scoring systems at 6 month (A), 12 month (B) and 24 month (C).</p