Re-colonizing spaces of memorializing: the case of the Chattri Indian Memorial, UK

This article inspects the ways that spaces of war memorialization are organized and reorganized through official and unofficial meaning-making activities. It aims to contribute to the discussion of the ‘value’ of memorializing by examining a multifaceted space of remembrance and commemoration: the Chattri Indian Memorial built near Brighton, UK. The article brings postcolonial perspectives to explore how memorializing has been organized here, focusing on the activities of once-colonized people and the affective, embodied aspects of organizing practices. Built in 1921 to honour Indian soldiers who fought in WWI, the Chattri evolved from a colonial instrument to symbol and space for ethnic-Indian group activities. The study employed historical, visual and ethnographic methods to study the tangible monument and the changing nature of the memorializing activities carried out around the monument. Memorializing is conceptualized within three inter-related processes: colonizing, de-colonizing and re-colonizing to examine how forms and practices of memorialization constitute a values-laden organizing system

Wright-Fisher diffusion bridges

The trajectory of the frequency of an allele which begins at $x$ at time $0$ and is known to have frequency $z$ at time $T$ can be modelled by the bridge process of the Wright-Fisher diffusion. Bridges when $x=z=0$ are particularly interesting because they model the trajectory of the frequency of an allele which appears at a time, then is lost by random drift or mutation after a time $T$. The coalescent genealogy back in time of a population in a neutral Wright-Fisher diffusion process is well understood. In this paper we obtain a new interpretation of the coalescent genealogy of the population in a bridge from a time $t\in (0,T)$. In a bridge with allele frequencies of 0 at times 0 and $T$ the coalescence structure is that the population coalesces in two directions from $t$ to $0$ and $t$ to $T$ such that there is just one lineage of the allele under consideration at times $0$ and $T$. The genealogy in Wright-Fisher diffusion bridges with selection is more complex than in the neutral model, but still with the property of the population branching and coalescing in two directions from time $t\in (0,T)$. The density of the frequency of an allele at time $t$ is expressed in a way that shows coalescence in the two directions. A new algorithm for exact simulation of a neutral Wright-Fisher bridge is derived. This follows from knowing the density of the frequency in a bridge and exact simulation from the Wright-Fisher diffusion. The genealogy of the neutral Wright-Fisher bridge is also modelled by branching P\'olya urns, extending a representation in a Wright-Fisher diffusion. This is a new very interesting representation that relates Wright-Fisher bridges to classical urn models in a Bayesian setting. This paper is dedicated to the memory of Paul Joyce

<i>SLC2A3</i> promotes glycolysis in OSCC.

The impact of overexpressed and knocked-down SLC2A3 on the intracellular levels of Lactic Acid (A), Glucose (B), and ATP (C). The overexpression groups SLC2A3 and si-SLC2A3 were compared with their negative controls, respectively.</p

<i>SLC2A3</i> promote the growth, invasion and migration of OSCC cells.

(A) SLC2A3 was successfully knocked down and overexpressed at the RNA and protein levels in SCC9 and SAS cells. (B-E) Cell growth was detected by colony formation and cell count. And the invasion, migration were detected by transwell and wound healing expriments, respectively. (F,G) These EMT-related protein levels were detected by western blot, while morphological changes(×1000) were analyzed by cell area and aspect ratio. In these analyses, the overexpression groups SLC2A3 and si-SLC2A3 were compared with their negative controls, respectively. Data are presented as means of three independent repeats ± standard deviations (SD).</p

Image4_Identification of an autophagy-related 12-lncRNA signature and evaluation of NFYC-AS1 as a pro-cancer factor in lung adenocarcinoma.JPEG

Objective: To develop an autophagy-related lncRNA-based risk signature and corresponding nomogram to predict overall survival (OS) for LUAD patients and investigate the possible meaning of screened factors.Methods: Differentially expressed lncRNAs and autophagy genes were screened between normal and LUAD tumor samples from the TCGA LUAD dataset. Univariate and multivariate Cox regression analyses were performed to construct the lncRNA-based risk signature and nomogram incorporating clinical information. Then, the accuracy and sensitivity were confirmed by the AUC of ROC curves in both training and validation cohorts. qPCR, immunoblot, shRNA, and ectopic expression were used to verify the positive regulation of NFYC-AS1 on BIRC6. CCK-8, immunofluorescence, and flow cytometry were used to confirm the influence of NFYC-AS1 on cell proliferation, autophagy, and apoptosis via BIRC6.Results: A 12-lncRNA risk signature and a nomogram combining related clinical information were constructed. Furthermore, the abnormal increase of NFYC-AS1 may promote LUAD progression through the autophagy-related gene BIRC6.Conclusion: 12-lncRNA signature may function as a predictive marker for LUAD patients, and NFYC-AS1 along with BIRC6 may function as carcinogenic factors in a combinatorial manner.</p

<i>SLC2A3</i> regulates malignant behavior of OSCC cells through the TGF-β pathway.

(A) Results of GSEA analysis of highly expressed SLC2A3, items with p SLC2A3 and knockdown group si-SLC2A3 were compared with their negative controls, respectively.</p

Impact of attitudinal ambivalence on safety behaviour in construction

Unsafe acts have been identified as a major factor of construction accidents. The Theory of Planned Behaviour (TPB) has been used to explain the factors influencing unsafe behaviour, by establishing the relationship between attitude, intention, and behaviour. However, the existing research on the relationship between safety attitude and safety behaviour could not fully explain the decision-making process of unsafe acts, in that the relationship could be mediated by attitudinal ambivalence, which is caused by conflicting information sources and the social network pressure of peer workers. This research examined whether attitudinal ambivalence was a mediating factor, either fully or partially, in the relationship between safety attitude and safety behaviour by expanding the TPB model. Data were collected from questionnaire survey of 228 construction workers. The results showed that attitudinal ambivalence existed as a partial mediating factor in the relationship between safety attitude and safety behaviour. '1 his paper contributed to the body of knowledge on safety management by recognizing the role of attitudinal ambivalence in construction workers and integrated it into the TPB model. This research will be helpful in providing greater understanding of the dynamic and complex decision-making process of unsafe behaviour given multiple information sources and conflicting environments

Lacitc acid is a mediator of TGF-β regulation by <i>SLC2A3</i>.

(A) The expression of SLC2A3 and TGF-β signaling pathway in SLC2A3-knockdown cells was detected by western blot after the lactic acid was added. (B,C) Cell invasion and migration were detected by transwell and would healing experiment, respectively. (D,E) The growth was detected by colony formation, and cell count. The comparsion of two pairs(sh-NC and sh-SLC2A3 LA(-); sh-SLC2A3 LA(-) and LA(+)) were respectively performed in these analysis.</p

The correlation between <i>SLC2A3</i> mRNA expression and clinicopathological features of OSCC patients based on the TCGA database.

The correlation between SLC2A3 mRNA expression and clinicopathological features of OSCC patients based on the TCGA database.</p