16 research outputs found

    Federal Recovery Funds Allocated

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    Figure S1. Overview of the informatics pipeline used to the identify lincRNAs in goat. (PDF 216 kb

    The Importance of Learning Islamic History and Civilization of Malaysia in the Building of Human Capital and Identity of the Muslim Society in Malaysia

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    AbstractThe purpose of this research is to study the importance of learning Islamic History and Civilization in Malaysia for human capital building and identification of the muslim society in Malaysia. Its aim is to clarify the importance of this course, specifically at the Department of Arabic Studies and Islamic Civilization, and the need to produce graduates who are conversant in this field in order that they may utilise it in their lives regardless of whichever field they venture into. This study uses the library research method by analysis and evaluation with an argumentative as well as narrative approach. The results of study finds that knowledge and conversance in this field is integral in the formation of human capital and identity of the muslim society in Malaysia. Knowledge and conversance in this field would enable Malays to know the ‘true’ history of the muslim ummah in Malaysia. This knowledge is crucial to help them form and build a Malay-muslim generation in Malaysia, strongly attached to Malay traditions which have once brought the muslims to the pinnacle of success

    Additional file 1 of Genetic characterization of dilated cardiomyopathy patients undergoing heart transplantation in the Chinese population by whole-exome sequencing

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    Additional file 1: Figure S1. Variant filtering flowchart for PCA. DCM, dilated cardiomyopathy; MAF, minor allele frequency; PCA, principal component analysis

    Additional file 2 of Genetic characterization of dilated cardiomyopathy patients undergoing heart transplantation in the Chinese population by whole-exome sequencing

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    Additional file 2: Figure S2. Variant filtering flowchart for gene burden analysis. DCM, dilated cardiomyopathy; MAF, minor allele frequency; REVEL, rare exome variant ensemble learner

    Additional file 3 of Genetic characterization of dilated cardiomyopathy patients undergoing heart transplantation in the Chinese population by whole-exome sequencing

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    Additional file 3: Table S1. Quality control statistics for sequencing. DCM, dilated cardiomyopathy; Q20, percentage of bases with a Phred score greater than 20 to the total bases; Q30, percentage of bases with a Phred score greater than 30 to the total bases. Table S2. The number of variants carried by each DCM patient before and after filtering. DCM, dilated cardiomyopathy. Table S3. Rare variants in high evidence genes identified in the Fuwai DCM HTx cohort. One TTN variant (NM_133379:exon46:c.C12949T:p.Q4317X) was predicted to be VUS since it affects only the Novex-3 isoform. Bold PMID represents the paper focused on the HTx patients. ACMG/AMP, American College of Medical Genetics and Genomics and the Association for Molecular Pathology; ACTC1, actin alpha cardiac muscle 1; ACTN2, actinin alpha 2; B, benign; BAG3, BAG cochaperone 3; DCM, dilated cardiomyopathy; DES, desmin; DSP, desmoplakin; FLNC, filamin C; HTx, heart transplantation; JPH2, junctophilin 2; LB, likely benign; LMNA, lamin A/C; LP, likely pathogenic; MYH7, myosin heavy chain 7; NEXN, nexilin F-actin binding protein; P, pathogenic; PLN, phospholamban; RBM20, RNA binding motif protein 20; SCN5A, sodium voltage-gated channel alpha subunit 5; TNNT2, troponin T2, cardiac type; TTN, titin; VUS, variant of unknown significance. Table S4. The clinical characterization of DCM in relation to P/LP variant status. Continuous variables are expressed as the mean ± SD values, and all categorical variables are depicted using relative frequency distributions. Disease course: months from symptom onset to heart transplantation. AF, atrial fibrillation; BAG3, BAG cochaperone 3; BMI, body mass index; DCM, dilated cardiomyopathy; FLNC, filamin C; IVS, interventricular septum; LAD, left atrial diameter; LMNA, lamin A/C; LP, likely pathogenic; LVEDD, left ventricular end-diastolic dimension; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association classification; P, pathogenic; RVD, right ventricle diameter; TTN, titin. P value < 0.05 = *, < 0.01 = **. Table S5. Clinical characterization of DCM in patients with one P/LP variant and those with more than one P/LP variant. Continuous variables are expressed as the mean ± SD values, and all categorical variables are depicted using relative frequency distributions. Disease course: months from symptom onset to heart transplantation. AF, atrial fibrillation; BMI, body mass index; DCM, dilated cardiomyopathy; IVS, interventricular septum; LAD, left atrial diameter; LP, likely pathogenic; LVEDD, left ventricular end-diastolic dimension; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association classification; P, pathogenic; RVD, right ventricle diameter

    Rock-Climbing in the Region of the Bohemian Paradise in the Second Half of the 20th Century

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    Rock climbing in the cities of the Bohemian Paradise became widely popular already by the end of the 19th century. Quite specific qualities of the local sandstone attracted domestic as well as foreign climbers right from the beginning. After 1948, many of the regional climbers, whose qualities were undisputable even in the nationwide scale, remained reliant upon climbing merely within the borders of the former Czechoslovakia. Until 1989, majority of them were not allowed to travel abroad and thus they could not prove their skills and qualities worldwide. There was a very limited number of those who could participate in foreign expeditions and thus fulfil their dreams. The rare contact with foreign climbers became a source of new information, new styles and trends in climbing, and an access to new equipment and gear in general. To many domestic climbers, however, such sources remained unattainable, and without them they were often left to develop and produce their equipment by their own, until they were allowed to travel to the West. This paper, with the help of the method of the oral history and qualitative subject analysis, gives a concise picture of the history of rock climbing in the Bohemian Paradise in the context of the constraints set by the communist Czechoslovakia. The chapters trace the..

    Additional file 4: of Genome-wide discovery of lincRNAs with spatiotemporal expression patterns in the skin of goat during the cashmere growth cycle

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    Figure S3. Characterization of the HF development-related gene expression in skin. Note: A. Number of RNA-seq reads obtained from the 15 samples at five time points. B. Histogram presenting differentially expressed genes with an adjusted P value ≤0.05 for at least one of the ten comparisons (May vs. Jun, May vs. Aug, May vs. Sep, May vs. Oct, Jun vs. Aug, Jun vs. Sep, Jun vs. Oct, Aug vs. Sep, Aug vs. Oct, and Sep vs. Oct). (PDF 275 kb

    Additional file 5: of Genome-wide discovery of lincRNAs with spatiotemporal expression patterns in the skin of goat during the cashmere growth cycle

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    Figure S4. Comparison of the expression patterns of selected lincRNAs and protein-coding genes detected in RNA-seq (red line) and RT-qPCR (blue line) assays revealing a high correlation between the two methods. Note: The log2 ratios of the expression changes during Oct relative to the other time points were calculated and plotted (the ratio was set to 0 for the normal condition). The expression levels of the selected protein-coding genes were normalized against that of β-actin. The expression levels of the selected lincRNAs were normalized against that of SDHA, UBC and YWHAZ. The R values (Pearson correlation coefficients) across the different time points are presented for each gene. (PDF 543 kb
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