13 research outputs found
Spearman rank correlation coefficients between year 7 and year 20 fibrinogen and CRP measurements.<sup>*</sup>
<p>*P<0.001 for each correlation coefficient shown.</p
Summary of the population from CARDIA included in the present analysis.
<p>Summary of the population from CARDIA included in the present analysis.</p
Adjusted loss of FVC and FEV<sub>1</sub> from year 5 to year 20 across race-sex specific quartiles of year 7 fibrinogen and CRP as well as linear regression coefficients for fibrinogen and log-transformed CRP as continuous variables.<sup>*</sup>
<p>*Adjusted for center, race-sex group, age, age-squared, height, and height-squared at year 20 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0011431#pone.0011431-Hankinson1" target="_blank">[19]</a>, BMI at the time of fibrinogen or CRP measurement, change in waist circumference from year 7 to year 20, cumulative pack-years of cigarette smoking, and year 5 lung function.</p>†<p>Multivariable linear regression coefficient for the prediction of change in lung function from year 5 to year 20 by year 7 fibrinogen or CRP</p
Characteristics of the subjects included in this analysis at the time of fibrinogen and CRP (year 7) measurement.<sup>a</sup>
a<p>Fibrinogen expressed in mg/dL, CRP expressed in µg/mL.</p
Adjusted odds ratios (95% CI) for COPD using the GOLD definition (FEV<sub>1</sub>/FVC ≤0.70) at year 20 across race- and sex-specific quartiles of year 7 CRP and per standard deviation of CRP stratified by pack-years cigarette exposure.<sup>*</sup>
<p>*Adjusted for center, cigarettes/day, and BMI at the time of CRP measurement, and waist circumference and cumulative pack-years of cigarette exposure at the time of spirometry.</p>†<p>Adjusted odds ratio for COPD per standard deviation of log-transformed year 7 CRP.</p>‡<p>Number of year 20 COPD cases in each smoking stratum.</p
Adjusted odds ratios (95% CI) for FEV<sub>1</sub> or FVC less than 80% predicted, COPD using the GOLD definition (FEV<sub>1</sub>/FVC ≤0.70) or a non-specific spirometry abnormality (FEV<sub>1</sub> and FVC <80% with FEV<sub>1</sub>/FVC >0.70) at year 20 across race- and sex-specific quartiles of year 7 fibrinogen and CRP and per standard deviation of fibrinogen or log-transformed CRP.<sup>*</sup>
<p>*Adjusted for center, cigarettes/d, BMI at the time of fibrinogen and CRP measurement, and waist circumference and cumulative pack-years of cigarette exposure at the time of spirometry.</p>†<p>Adjusted odds ratio per standard deviation of year 7 fibrinogen or log-transformed CRP.</p>‡<p>Test for CRP x pack-years cigarette exposure interaction significant (<i>P</i> = 0.005).</p
Relationship between age, lung function and quartile of fibrinogen or CRP (measured at year 7).
<p>Spirometry exams performed at CARDIA visits at years 5, 10, and 20 were used to determine a mean lung function for each 2 year age group across year 7 CRP or fibrinogen quartiles, and slopes compared between the highest and lowest quartile groups. For both fibrinogen and CRP, the age-related decline in FVC was significantly different between quartiles 1 and 4. There were no significant differences in the FEV<sub>1</sub> across CRP or fibrinogen quartiles.Covariates in the model include race-sex group, exam year, pack-years of cigarette exposure, and time-dependent age, time-dependent height and height-squared, and year 5 waist circumference and time-dependent change in waist circumference.</p
The correlation between right ventricular echocardiographic parameters and six minute walk distance.
<p>Panel 2A: The correlation between right atrial area (cm<sup>2</sup>) and six minute walk distance (meters); (r = −0.4, p = 0.002). Panel 2B: The correlation between right ventricular wall thickness (cm) and six minute walk distance (meters); (r = −0.4, p = 0.002).</p
The correlation between right ventricular echocardiographic parameters and pulmonary artery systolic pressure estimates.
<p>Panel 1A: The correlation between pulmonary artery systolic pressure (mmHg) and right ventricular wall thickness (cm). Panel 1B: The correlation between pulmonary artery systolic pressure (mmHg) and right ventricular basilar diameter (cm). Panel 1C: The correlation between pulmonary artery systolic pressure (mmHg) and right atrial area (cm<sup>2</sup>). Panel 1D: The correlation between pulmonary artery systolic pressure (mmHg) and right ventricular end diastolic area (cm<sup>2</sup>).</p
Left Heart Parameters by COPD Severity.
<p>LV; left ventricular, LA; left atrial.</p><p>*ANOVA comparing mild, moderate, moderately severe.</p