Choroidal rupture: Eyewiki

<p>Choroidal rupture</p> <p>-</p> <p>Original article contributed by: Sharon Fekrat, MD<br>All contributors: Koushik Tripathy, Sharon Fekrat, MD and Theodore Leng, MD, MS</p> <p> </p> <p>http://eyewiki.org/Choroidal_rupture</p> <p> </p

Supplemental Material, ds-vrd-10.1177_2474126418786659 - Longitudinal Follow-Up of Choroidal Thickness in Central Retinal Vein Occlusion With and Without Cystoid Macular Edema

<p>Supplemental Material, ds-vrd-10.1177_2474126418786659 for Longitudinal Follow-Up of Choroidal Thickness in Central Retinal Vein Occlusion With and Without Cystoid Macular Edema by Atalie C. Thompson, Akshay S. Thomas, Adam L. Rothman, Duncan Berry, and Sharon Fekrat in Journal of VitreoRetinal Diseases</p

Generalized estimating equation analysis on OCTA parameters in individuals with motor manifest HD and controls.

Generalized estimating equation analysis on OCTA parameters in individuals with motor manifest HD and controls.</p

S1 Data -

ObjectiveTo characterize retinal and choroidal microvascular and structural changes in patients who are gene positive for mutant huntingtin protein (mHtt) with symptoms of Huntington’s Disease (HD).MethodsThis study is a cross-sectional comparison of patients who are gene positive for mHtt and exhibit symptoms of HD, either motor manifest or prodromal (HD group), and cognitively normal individuals without a family history of HD (control group). HD patients were diagnosed by Duke movement disorder neurologists based on the Unified Huntington’s Disease Rating Scale (UHDRS). Fovea and optic nerve centered OCT and OCTA images were captured using Zeiss Cirrus HD-5000 with AngioPlex. Outcome metrics included central subfield thickness (CST), peripapillary retinal nerve fiber layer (pRNFL) thickness, ganglion cell-inner plexiform layer (GCIPL) thickness, and choroidal vascularity index (CVI) on OCT, and foveal avascular zone (FAZ) area, vessel density (VD), perfusion density (PD), capillary perfusion density (CPD), and capillary flux index (CFI) on OCTA. Generalized estimating equation (GEE) models were used to account for inter-eye correlation.ResultsForty-four eyes of 23 patients in the HD group and 77 eyes of 39 patients in the control group were analyzed. Average GCIPL thickness and FAZ area were decreased in the HD group compared to controls (p = 0.001, p ConclusionsPatients in the HD group had decreased GCIPL thickness and smaller FAZ area, highlighting the potential use of retinal biomarkers in detecting neurodegenerative changes in HD.</div

Correlation coefficients between retinal parameters and number of CAG repeats in the HD group.

Correlation coefficients between retinal parameters and number of CAG repeats in the HD group.</p

STROBE statement—checklist of items that should be included in reports of observational studies.

STROBE statement—checklist of items that should be included in reports of observational studies.</p

Generalized estimating equation analysis on OCT parameters in individuals in the HD group and control group.

Generalized estimating equation analysis on OCT parameters in individuals in the HD group and control group.</p

Generalized estimating equation analysis on OCT parameters in individuals with motor manifest HD and controls.

Generalized estimating equation analysis on OCT parameters in individuals with motor manifest HD and controls.</p

Representative Optical Coherence Tomography Angiography (OCTA) scan of control and Huntington’s Disease participants.

Representative OCTA 3x3mm images of the superficial capillary plexus (SCP) of the right eye of a 38 year old male control subject (A) and the right eye of a 44 year old male Huntington’s Disease (HD) subject (C) show decreased FAZ area in the subject with HD. Corresponding quantitative color maps (Carl Zeiss Meditec, Dublin, CA) of the ganglion cell layer, with the scale on the right show attenuation in the subject with HD (D) compared to the control subject (B).</p

Generalized estimating equation analysis on OCTA parameters in individuals in the HD group and control group.

Generalized estimating equation analysis on OCTA parameters in individuals in the HD group and control group.</p