23 research outputs found

    Illustration of the bead-picture match task.

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    <p>Schematic illustration of 1 trial of the experiment design, the bead-picture match task.</p

    Between-group differences after SFN correction.

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    <p>Group differences in the rOFC region (marked) were consistently detected for all three templates when the SFN was included as a covariate (<i>p</i> < 0.05, AlphaSim corrected). Red indicates trained group > control group; blue indicates trained group < control group.</p

    Mean (±Standard Deviation) of the SFN in the two groups across the three templates.

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    <p>Mean (±Standard Deviation) of the SFN in the two groups across the three templates.</p

    Relationship between response time and BOLD contrast size in the rOFC.

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    <p>The relationship between the subject’s response time in the trained group and BOLD contrast size in the rOFC were correlated (<i>p</i> < 0.05) for the CCT (<i>r</i> = -0.54, <i>p</i> = 0.019) and SST (<i>r</i> = -0.51, <i>p</i> = 0.023) templates, but not for the MNI template (<i>r</i> = -0.39, <i>p</i> = 0.192) <b>(a)</b>. After SFN correction, significant correlations were observed across all three templates in the trained group (MNI: <i>r</i> = -0.59, <i>p</i> = 0.017; CCT: <i>r</i> = -0.59, <i>p</i> = 0.016; SST: <i>r</i> = -0.57, <i>p</i> = 0.02) <b>(b)</b>. However, no negative correlation was observed in the control group without (MNI: <i>r</i> = -0.48, <i>p</i> = 0.119; CCT: <i>r</i> = -0.52, <i>p</i> = 0.087; SST: <i>r</i> = -0.47, <i>p</i> = 0.151) or with (MNI: <i>r</i> = -0.46, <i>p</i> = 0.115; CCT: <i>r</i> = -0.49, <i>p</i> = 0.091; SST: <i>r</i> = -0.51, <i>p</i> = 0.077) SFN correction, regardless of the brain template used <b>(c, d)</b>.</p

    Between-group differences in the rOFC region across three templates.

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    <p>Significant between-group differences in the rOFC region (marked by red circle) were observed using both the CCT and SST templates, but not the MNI template (<i>p</i> < 0.05, AlphaSim corrected). Red indicates trained group > control group; blue indicates trained group < control group.</p

    Regions of significant between-group differences, coordinates (x, y, z) and T-values of local maxima detected across three templates for the bead-picture match task without and with SFN correction (<i>p</i> < 0.05, AlphaSim corrected).

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    <p>Regions of significant between-group differences, coordinates (x, y, z) and T-values of local maxima detected across three templates for the bead-picture match task without and with SFN correction (<i>p</i> < 0.05, AlphaSim corrected).</p

    Whole-brain correlation maps of the SFN and BOLD contrast size.

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    <p>Voxel-based whole-brain correlation maps of the SFN and BOLD contrast size (<i>p</i> < 0.05, AlphaSim corrected) among the three templates.</p

    Correlations between BOLD contrast size and the SFN in the rOFC.

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    <p>Scatter plot showing the distribution of BOLD contrast size in the rOFC as a function of the SFN. (a) The SFN was significantly correlated with BOLD contrast size (<i>p</i> < 0.05) among the three templates in the trained group (MNI: <i>r</i> = -0.65, <i>p</i> = 0.006; CCT: <i>r</i> = -0.59, <i>p</i> = 0.015; SST*: <i>r</i> = -0.54, <i>p</i> = 0.036). (b) Scatter plot revealing that the SFN had no effect on BOLD contrast size among the three templates in the control group (MNI: <i>r</i> = -0.30, <i>p</i> = 0.320; CCT: <i>r</i> = -0.40, <i>p</i> = 0.177; SST: <i>r</i> = -0.29, <i>p</i> = 0.338). (* one subject had much smaller SFN (3.48) than others in the trained group (mean SFN 3.82), but there was no difference when all subjects were considering. This subject’s data were not included in this correlation analysis.)</p

    Active regions during the bead-picture match task.

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    <p>Regions activated during the bead-picture match task in each group (<i>p</i> < 0.05, AlphaSim corrected). Activation in the rOFC (marked in red circle) was only observed in the trained group, and not in the control group.</p

    Table1_Dl-3-n-butylphthalide attenuates cerebral ischemia/reperfusion injury in mice through AMPK-mediated mitochondrial fusion.DOCX

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    Introduction: NBP is a compound isolated from celery seeds, which was approved by the National Medical Products Administration in 2002 for clinical treatment of ischemic stroke. However, in brain ischemia/reperfusion (I/R) injury, the related research on mitochondrial dynamics and its mechanism of action of NBP still need to be further studied. The aim of this study was to assess NBP on cerebral pathology in ischemic stroke in vivo, with a specific focus on the molecular mechanisms of how NBP promotes mitochondrial fusion.Methods: Male C57BL/6 mice were utilized in this study and were subjected to middle cerebral artery occlusion/reperfusion (MCAO/R). Pre-ischemia, NBP was administered through intraperitoneal (i.p.) injection for 7 days.Results: Our findings demonstrated that NBP effectively reduced infarct volume, improved neurological dysfunction, enhanced cerebral blood flow, and promoted mitochondrial fusion in mice subjected to MCAO/R. More importantly, the pro-fusion effects of NBP were found to be linked to the activation of AMPK/Mfn1 pathway, and with the activation of neurological function, which was partially eliminated by inhibitors of AMPK.Discussion: Our results revealed that NBP is a novel mitochondrial fusion promoter in protecting against ischemic stroke through the AMPK-mediated Mfn1. These findings contribute to the understanding of novel mechanisms involved in the protection of neurological function following NBP treatment for ischemic stroke.</p
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