Sex party first aid guide.

One of the best resources we have to keep ourselves, our friends, and those we play with safe in sex party environments – is each other. Learning some first aid skills, while remembering how vulnerable we can be if we’re using drugs for sex, can improve our chances of avoiding accidents, overdoses and deaths

Emerging climate-driven disturbance processes: Widespread mortality associated with snow-to-rain transitions across 10° of latitude and half the range of a climate-threatened conifer

Climate change is causing rapid changes to forest disturbance regimes worldwide. While the consequences of climate change for existing disturbance processes, like fires, are relatively well studied, emerging drivers of disturbance such as snow loss and subsequent mortality are much less documented. As the climate warms, a transition from winter snow to rain in high latitudes will cause significant changes in environmental conditions such as soil temperatures, historically buffered by snow cover. The Pacific coast of North America is an excellent test case, as mean winter temperatures are currently at the snow–rain threshold and have been warming for approximately 100 years post-Little Ice Age. Increased mortality in a widespread tree species in the region has been linked to warmer winters and snow loss. Here, we present the first high-resolution range map of this climate-sensitive species, Callitropsis nootkatensis (yellow-cedar), and document the magnitude and location of observed mortality across Canada and the United States. Snow cover loss related mortality spans approximately 10° latitude (half the native range of the species) and 7% of the overall species range and appears linked to this snow–rain transition across its range. Mortality is commonly >70% of basal area in affected areas, and more common where mean winter temperatures is at or above the snow–rain threshold (>0 °C mean winter temperature). Approximately 50% of areas with a currently suitable climate for the species (< 2 °C) are expected to warm beyond that threshold by the late 21st century. Regardless of climate change scenario, little of the range which is expected to remain suitable in the future (e.g., a climatic refugia) is in currently protected landscapes (<1–9%). These results are the first documentation of this type of emerging climate disturbance and highlight the difficulties of anticipating novel disturbance processes when planning for conservation and management.Ye

Community needs of gbMSM in Ireland in Response to Mpox Public Health Emergency of International Concern

The 2023 Society for the Study of Sexually Transmitted Diseases (SSTDs) Autumn Meeting, Royal Marine Hotel Dun Laoghaire, Ireland, 18 November 2023Introduction: In May 2022 there was a growing number of globally reported cases of mpox, most reported in communities of gay, bisexual and other men who have sex with men (gbMSM). In July 2022, the WHO designated the outbreak as a Public Health Emergency of International Concern (PHEIC; Nuzzo et al., 2022). The first mpox case was reported in Ireland on the 27th of May 2022 and confirmed reported cases to the end of 2022 stood at 227. Throughout the response to the PHEIC, community organisations were responsible for leading community-focussed communication and support. Methods: ● A cross sectional, online, mixed methods survey was deployed and completed by 163 gay and bisexual men in Ireland. ● Descriptive statistical analysis for quantitative data. ● Reflexive Thematic Analysis informed by Critical realism utilised for qualitative open ended answers (Braun et al 2021) Results: Quantitative responses focussed on perceptions of mpox, sources of information on mpox and perceived trustworthiness of information sources. Qualitative responses reflected four broad themes 1. Perceptions of the mpox response: divergence in urgency, priority & care 2. The mpox outbreak as a sign of otherness for gbMSM. 3. The potential for othering through mpox prevention practices. 4. Fear of mpox and the influence of previous culturally significant pandemics. Discussion: While there was dissatisfaction with the response from statutory public health agencies reflected by participants, overall participants felt well informed and supported within the community and by community organisations. This would suggest that the strategy to engage with the community through community organisations was a successful one. 11 recommendations were co-developed with the expert advisory group, including the formation of a national LGBTQ+ health strategy, further investment in sexual health infrastructure, equity and inclusion audits of public health strategies amongst others.HIV Ireland, MPOWER Programm

Community Needs Analysis of Gay, Bisexual and MSM Communities in Ireland in response to Mpox

The 2023 GLMA Annual Conference, Virtual Event, 28-30 September 2023The first cases of mpox were noted in Ireland in late May 2022, which were part of a WHO designated Public Health Emergency of International Concern. This poster presents findings of a community needs analysis carried out with gay, bisexual and other men who have sex with men through an online mixed methods surveyHIV Ireland, MPOWER Programm

Two Out of Three Ain’t Bad: 3 Year Progress Report of Multi-Species Non-Invasive Montioring of Forest Carnivores in the Southwest Crown of the Continent

The Southwestern Crown of the Continent is a 1.5 million acre landscape in western Montana that has been the focus of collaborative forest restoration since 2010. Monitoring the effects on forest carnivores of forest restoration efforts can aid land management decisions significantly. A multi-party working group initiated field work to collect baseline information regarding the distribution and relative abundance of forest carnivores across the Southwestern Crown. In the winters of 2012-2014, we employed non-invasive detection methods, including systematic grid-based snowtrack surveys (with backtracking to obtain genetic samples), combined with baited DNA snares and camera traps, to detect target species, including lynx (Lynx canadensis), wolverine (Gulo gulo), and fisher (Pekania pennanti). We surveyed 82 of the 129 5 x 5 mile grid cells in the study area, resulting in 3,366 miles of track surveys, and 274+ bait stations.  We detected lynx in 35 cells and wolverine in 38 cells. The number of cells where lynx were detected was consistent between survey years, while the number of wolverine detection cells increased each survey year.  We did not detect any fisher in the study area.  Genetics have identified at least 18 individual lynx (13 M, 5 F) and 15 individual wolverines (6 M, 9 F).  The combination of two detection methods improved our ability to detect species, including non-target species, compared with either method alone. Our methods could be deployed more widely in Montana

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10⁻⁸, HR = 1.14, 95% CI: 1.09–1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10⁻⁸, HR = 1.27, 95% CI: 1.17–1.38) and 4q32.3 (rs4691139, P = 3.4×10⁻⁸, HR = 1.20, 95% CI: 1.17–1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific association. The 17q21.31 locus was also associated with ovarian cancer risk in 8,211 BRCA2 carriers (P = 2×10⁻⁴). These loci may lead to an improved understanding of the etiology of breast and ovarian tumors in BRCA1 carriers. Based on the joint distribution of the known BRCA1 breast cancer risk-modifying loci, we estimated that the breast cancer lifetime risks for the 5% of BRCA1 carriers at lowest risk are 28%–50% compared to 81%–100% for the 5% at highest risk. Similarly, based on the known ovarian cancer risk-modifying loci, the 5% of BRCA1 carriers at lowest risk have an estimated lifetime risk of developing ovarian cancer of 28% or lower, whereas the 5% at highest risk will have a risk of 63% or higher. Such differences in risk may have important implications for risk prediction and clinical management for BRCA1 carriers

Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations

To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi-national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic germline mutation in the BRCA1 or BRCA2 genes. Men enrolled in the IMPACT study were invited to complete a questionnaire at collaborating sites prior to each annual screening visit. The questionnaire included sociodemographic characteristics and the following measures: the Hospital Anxiety and Depression Scale (HADS), Impact of Event Scale (IES), 36-item short-form health survey (SF-36), Memorial Anxiety Scale for Prostate Cancer, Cancer Worry Scale-Revised, risk perception and knowledge. The results of the baseline questionnaire are presented. A total of 432 men completed questionnaires: 98 and 160 had mutations in BRCA1 and BRCA2 genes, respectively, and 174 were controls (familial mutation negative). Participants' perception of PCa risk was influenced by genetic status. Knowledge levels were high and unrelated to genetic status. Mean scores for the HADS and SF-36 were within reported general population norms and mean IES scores were within normal range. IES mean intrusion and avoidance scores were significantly higher in BRCA1/BRCA2 carriers than in controls and were higher in men with increased PCa risk perception. At the multivariate level, risk perception contributed more significantly to variance in IES scores than genetic status. This is the first study to report the psychosocial profile of men with BRCA1/BRCA2 mutations undergoing PCa screening. No clinically concerning levels of general or cancer-specific distress or poor quality of life were detected in the cohort as a whole. A small subset of participants reported higher levels of distress, suggesting the need for healthcare professionals offering PCa screening to identify these risk factors and offer additional information and support to men seeking PCa screening

LGBTI: 'We are pleased to see chemsex included in the National Drugs Strategy'.

The recently launched National Drug Strategy was welcomed by community activists this week. Having being renamed “Reducing Harm, Supporting Recovery — a health-led response to drug and alcohol use in Ireland 2017-2025”, it heralds a move away from a punishment approach to one of harm reduction and care.........

The Use of Guitar in Anton Webern's Op. 18 and its Influence on His Late Works

Anton Webern’s Op. 18 stands at nearly the exact center of his published work. Though it was in his Op. 17 that Webern began working with ordered pitches, there are some logistic struggles evident in his diversions from the row throughout that work. It is in Op. 18 that Webern first consistently uses a row in its complete, unchanged form. His increasing mastery of this style of composition is shown throughout Op. 18, a collection of three songs; the first with a single row repeated with no permutations of any kind; in the 2nd song, inversions and retrograde are introduced; and in the final song Webern experiments with simultaneous unique row forms for each instrument. These songs feature a guitar, E-flat clarinet, and soprano voice, with the first song a setting of a folk text. In this dissertation I argue that Webern’s later style–his orchestration, harmonic progressions, and formal structures–grows out of his choice of guitar as harmonic foundation in Op. 18. In my analysis I look at row construction and usage, as well as orchestrational considerations, folk implications, text setting, and specific voice-leading properties of Webern’s Opp. 18, 25, and 30. In so doing I will uncover a link between Webern’s pivotal Op. 18 song cycle, with the guitar playing a central role, and many of his compositional choices in his later works. My analysis looks at Webern’s works through the lens of a guitarist. I will explore the piano accompaniment of Op. 25 as if it were written for guitar, and do the same for his Op. 30 Variations for Orchestra. These analyses will show that his later works, and later style in general, have an underlying idiomatic character of guitar music. I argue that Webern’s late works feature, as a result, are his own version of folk music through their simplicity, clarity of form, and overall encapsulation of the sound of the guitar