Termination of Pregnancy After NonInvasive Prenatal Testing (NIPT): Ethical Considerations

This article explores the Nuffield Council on Bioethics’ recent report about non-invasive prenatal testing. Given that such testing is likely to become the norm, it is important to question whether there should be some ethical parameters regarding its use. The article engages with the viewpoints of Jeff McMahan, Julian Savulescu, Stephen Wilkinson and other commentators on prenatal ethics. The authors argue that there are a variety of moral considerations that legitimately play a significant role with regard to (prospective) parental decision-making in the context of NIPT, for example, views on the morality of abortion and understandings of the impact of disability on quality of life. The variable nature of such considerations, both singularly and combined, suggests that any approach to NIPT should be sensitive to and understanding of similarly variable parental assessments and decisions. The implications of the approach developed for current and future policies in this area are explored, along with the impact of such arguments on ideas about procreative beneficence

Occupying (dis)ordinary space

This paper starts by outlining some key work in ethnomethodology, which understands everyday, unnoticed social and spatial practices as “problematic accomplishments ”(Ryave and Schenkein:1974 65-274). Such practices involve a considerable amount of detailed ─ usually seen but un-noticed ─ work in order to maintain the commonplace world where people know what ‘anyone’ knows and does. We are interested to show how doing ‘nothing much’ is a socially achieved activity; how such ordinariness has consequence for those who specifically 'cannot be ordinary'; and in the implications for the everyday occupation(s) of built space. We do this by investigating occupation through the narratives and strategies of diverse disabled people using a tactic that Garfinkel calls breaching. He argues that the underlying practices in commonplace situations are best made visible through their disruption, through ‘making trouble’ (1967, 37-8). Disabled people are often not perceived as ‘anyone’ – not because of any particular impairment but because they do not fit the unspoken conventions of what constitutes doing ‘being ordinary’ (Sacks: 1984 413-429). Here we outline how a disabled-led perspective on occupation can reveal both the amount of work involved in negotiating physical space and how it goes unnoticed as ‘nothing much’. Finally, we look briefly at Milton Keynes Shopping Centre to explore what kinds of descriptions of buildings such an approach might offer. We suggest that rather than simply mirroring what ‘anyone’ knows or does, the design of a particular built space intersects in complex ways with occupation and doing being ordinary

The swarming logic of inversion and the elevation of Satan

Editors' prefac

Facilitating text reading in posterior cortical atrophy

Objective We report 1) the first quantitative investigation of text reading in posterior cortical atrophy (PCA); and 2) the effects of two novel software-based reading aids that result in dramatic improvements in PCA patients' reading ability. Methods Reading performance, eye movements and fixations were assessed in PCA and typical Alzheimer’s disease (tAD) patients and healthy controls (Experiment 1). Two reading aids (single- and double-word) were evaluated based on the notion that reducing the spatial and oculomotor demands of text reading might support reading in PCA (Experiment 2). Results PCA patients’ mean reading accuracy was significantly worse (57%) compared to both tAD patients (98%) and healthy controls (99%); spatial aspects of passages were the primary determinants of text reading ability in PCA. Both aids led to considerable gains in reading accuracy (PCA mean reading accuracy: single-word reading aid = 96%; individual patient improvement range: 6%-270%) and self-rated measures of reading. Data suggest a greater efficiency of PCA patients’ fixations and eye movements under the single-word reading aid. Conclusions These findings demonstrate how neurological characterisation of a neurodegenerative syndrome (PCA) and detailed cognitive analysis of an important everyday skill (reading) can combine to yield aids capable of supporting important everyday functional abilities. Classification of evidence This study provides Class III evidence that for patients with posterior cortical atrophy, two software-based reading aids (single-word and double-word) improve reading accuracy

Mean link versus average plaquette tadpoles in lattice NRQCD

We compare mean-link and average plaquette tadpole renormalization schemes in the context of the quarkonium hyperfine splittings in lattice NRQCD. Simulations are done for the three quarkonium systems $c\bar c$, $b\bar c$, and $b\bar b$. The hyperfine splittings are computed both at leading and at next-to-leading order in the relativistic expansion. Results are obtained at a large number of lattice spacings. A number of features emerge, all of which favor tadpole renormalization using mean links. This includes much better scaling of the hyperfine splittings in the three quarkonium systems. We also find that relativistic corrections to the spin splittings are smaller with mean-link tadpoles, particularly for the $c\bar c$ and $b\bar c$ systems. We also see signs of a breakdown in the NRQCD expansion when the bare quark mass falls below about one in lattice units (with the bare quark masses turning out to be much larger with mean-link tadpoles).Comment: LATTICE(heavyqk) 3 pages, 2 figure

Pushing NRQCD to the limit

Lattice NRQCD has proven successful in describing the physics of the upsilon system and B-mesons, though some concerns arise when it is used in simulations of charm quarks. It is certainly possible that the NRQCD expansion is not converging fast enough at this scale. We present some preliminary results on the low-mass breakdown of NRQCD, in particular the behaviour of heavy quarkonium and heavy-light meson spectra as the bare heavy quark mass is decreased well below 1, with the aim of understanding more about the manifestation of this breakdown.Comment: Lattice 99 submission, 3 Pages, 3 eps figure