Tract-based spatial statistics analyses identified white matter areas affected by a significant decrease in fractional anisotropy (FA) in patients with psychotic bipolar disorder (PBD) (N = 29), non-psychotic bipolar disorder (NPBD) (N = 23), and bipolar disorder (BD) (N = 52) in comparisons with healthy controls (HCs) (N = 65).

Family-wise error corrected P < 0.0062.</p

Demographic and clinical characteristics.

Demographic and clinical characteristics.</p

Comparisons of fractional anisotropy among PBD (N = 29), NPBD (N = 23), BD (PBD + NPBD) (N = 52), and HC (N = 65) groups^a.

Comparisons of fractional anisotropy among PBD (N = 29), NPBD (N = 23), BD (PBD + NPBD) (N = 52), and HC (N = 65) groupsa.</p

Comparisons of mean diffusivity among PBD (N = 29), NPBD (N = 23), BD (PBD + NPBD) (N = 52), and HC (N = 65) groups^a.

Comparisons of mean diffusivity among PBD (N = 29), NPBD (N = 23), BD (PBD + NPBD) (N = 52), and HC (N = 65) groupsa.</p

Tract-based spatial statistics analyses identified white matter areas affected by a significant increase in mean diffusivity (MD) in patients with psychotic bipolar disorder (PBD) (N = 29), non-psychotic bipolar disorder (NPBD) (N = 23), and bipolar disorder (BD) (N = 52) in comparisons with healthy controls (HCs) (N = 65).

Family-wise error corrected P < 0.0062.</p

Trends in the numbers of suicides per month between 1997 and 2018 in Korea.

The dots represent the numbers of suicides and the red dashed line indicates the trend. The blue vertical dotted lines indicate the dates of celebrity suicides. (TIF)</p

Observed and expected numbers of suicides by age group per month between 2017 and 2020 in Korea.

The red line with circles represents the observed number of suicides between 2017 and 2020. The blue line with triangles represents the expected number of suicides according to forecasting models and the surrounding blue area indicates the 95% confidence interval (with 2019 as the validation period). The blue vertical dotted lines indicate the dates of celebrity suicides.</p

Number of suicides per month during the COVID-19 pandemic in Korea.

Number of suicides per month during the COVID-19 pandemic in Korea.</p

Trends in the numbers of suicides by age group per month between 1997 and 2018 in Korea.

The dots represent the numbers of suicides and the red dashed line indicates the trend. The blue vertical dotted lines indicate the dates of celebrity suicides. (TIF)</p

Number of male and female suicides per month during the COVID-19 pandemic in Korea.

Number of male and female suicides per month during the COVID-19 pandemic in Korea.</p