1,262 research outputs found

    A Study on Policymaking in New Zealand: AnExploratory Study of Two Cases

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    This thesis seeks to explore why some issues are more prominent than others. I seek to find out why the debate on Genetic Engineering featured so prominently; whilst Nano-molecular Technology (NMT) received little if no attention when it comes to its government policy formulation. Using Agenda Setting Theory and Veto Player Theory, I seek to explain the differences between the policy debate processes and its outcomes for the GM and NMT. The findings of this thesis suggest Agenda Setting Theory failed to account for the lack of change in policy on the issue of Genetic Engineering. It is argued that Veto Player Theory is a better model for explaining policy outcomes and predicting the likelihood of policy changes

    Prioritizing Metro Service Quality Attributes to Enhance Commuter Experience: TOPSIS Ranking and Importance Satisfaction Analysis methods

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    A metro infrastructure, facility and service quality investigation based on commuter perception was conducted in this study to explore and prioritize the key attributes influencing overall metro service quality in typical Indian context. Based on the critical state of the art review, 12 key attributes were identified and they were accommodated in a paper based questionnaire to elicit commuter perception of importance and satisfaction by using a five point Likert scale. Subsequently, TOPSIS, an extensively adopted Multi attribute decision making technique, was carried out to rank the attributes with respect to perceived importance and satisfaction. Then an importance satisfaction analysis (ISA) was conducted to further classify the attributes in four quadrants based on their perceived degree of importance and satisfaction using an ISA matrix. Finally, the derived results from the TOPSIS and ISA analysis were combined and compared to obtain a prioritized set of attributes requiring intervention for better metro service quality in Indian context. Results of this study clearly indicated the relative strengths and weaknesses of each metro service/infrastructure specific attribute and presented the probable role of metro authorities for each of them. Attributes such as, Metro fare, Connection to metro and Metro frequency were observed to be the most important but were not performing satisfactorily, indicating that more emphasis is required on these attributes for improving the overall quality of travel by metro rail in Indian context. Hence, this methodology would be instrumental to detect a set of priority areas of improvement in metro rail service, which could contribute to retain the existing commuters and attract new metro users

    A novel role for Lyl1 in primitive erythropoiesis

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    © 2018. Published by The Company of Biologists Ltd. Stem cell leukemia (Scl or Tal1) and lymphoblastic leukemia 1 (Lyl1) encode highly related members of the basic helix-loop-helix family of transcription factors that are co-expressed in the erythroid lineage. Previous studies have suggested that Scl is essential for primitive erythropoiesis. However, analysis of single-cell RNA-seq data of early embryos showed that primitive erythroid cells express both Scl and Lyl1. Therefore, to determine whether Lyl1 can function in primitive erythropoiesis, we crossed conditional Scl knockout mice with mice expressing a Cre recombinase under the control of the Epo receptor, active in erythroid progenitors. Embryos with 20% expression of Scl from E9.5 survived to adulthood. However, mice with reduced expression of Scl and absence of Lyl1 (double knockout; DKO) died at E10.5 because of progressive loss of erythropoiesis. Gene expression profiling of DKO yolk sacs revealed loss of Gata1 and many of the known target genes of the SCL-GATA1 complex. ChIP-seq analyses in a human erythroleukemia cell line showed that LYL1 exclusively bound a small subset of SCL targets including GATA1. Together, these data show for the first time that Lyl1 can maintain primitive erythropoiesis

    Dataset on gene expression in the elderly after Mindfulness Awareness Practice or Health Education Program

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    It has been reported that relaxation techniques can improve physical health and cognitive function. A number of studies involving different types of relaxation practices showed changes in expression of genes. We investigated the gene expression pattern of a cohort of elderly subjects of Asian descent after weekly (for the first three months) and monthly (for the subsequent six months) intervention. Sixty consenting elderly subjects (aged 60–90 years) with mild cognitive impairment were assigned to either the Mindfulness Awareness Practice (MAP) or Health Education Program (HEP) group in a randomized controlled trial to assess the effectiveness of the programs in preventing further cognitive decline and evaluate the influence on neurological, cellular and biochemical factors. Blood samples were collected before the start of intervention and after nine months for gene expression profiling using Affymetrix Human Genome U133 Plus 2.0 arrays. The dataset is publicly available for further analyses

    Infant feeding practices in a multi-ethnic Asian cohort: the GUSTO study

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    The optimal introduction of complementary foods provides infants with nutritionally balanced diets and establishes healthy eating habits. The documentation of infant feeding practices in multi-ethnic Asian populations is limited. In a Singapore cohort study (GUSTO), 842 mother-infant dyads were interviewed regarding their feeding practices when the infants were aged 9 and 12 months. In the first year, 20.5% of infants were given dietary supplements, while 5.7% took probiotics and 15.7% homeopathic preparations. At age 9 months, 45.8% of infants had seasonings added to their foods, increasing to 56.3% at 12 months. At age 12 months, 32.7% of infants were given blended food, although 92.3% had begun some form of self-feeding. Additionally, 87.4% of infants were fed milk via a bottle, while a third of them had food items added into their bottles. At both time points, more than a third of infants were provided sweetened drinks via the bottle. Infants of Indian ethnicity were more likely to be given dietary supplements, have oil and seasonings added to their foods and consumed sweetened drinks from the bottle (p < 0.001). These findings provide a better understanding of variations in infant feeding practices, so that healthcare professionals can offer more targeted and culturally-appropriate advice