Network of cluster centres of stage-III network.

<p>Clustering was done using Moduland.</p

Network of cluster centres of stage-IV network.

Clustering was done using Moduland.</p

Centrality analysis of stage-II network.

<p>Centrality analysis of stage-II network.</p

GO enrichment analysis of stage-IV network.

<p>GO enrichment analysis of stage-IV network.</p

Moduland decomposition of stage-IV network.

Moduland decomposition of stage-IV network.</p

From tumor genome-sequencing data to network reconstruction.

<p>From tumor genome-sequencing data to network reconstruction.</p

Staging of colon cancer.

<p>The American Joint Committee on Cancer (AJCC) has staged the colorectal cancer based on the anatomical extent of the disease. Stage I: Tumor that is limited to the mucosal layer (T1) or muscularis propria (T2), without involvement of any lymph node or distant metastatic organs. Stage II: Tumor that penetrates the muscularis propria (T3) or invades nearby organs or structures (T4), without involvement of any lymph node or distant metastatic organs. Stage III: Tumor stages with lymph node metastasis but without distant metastasis. Stage IV: Any tumor stage and lymph node status with distant organ metastasis.</p

Identification of hub driver genes.

<p>Consensus novel driver genes were identified for each stage from driverDB data. Consensus central genes (‘hubs’) were identified from each stage-specific network. The overlap between these two sets of genes yields ‘hub driver’ genes for each stage.</p

Centrality analysis of stage-IV network.

<p>Centrality analysis of stage-IV network.</p

Network of cluster centres of stage-II network.

<p>Clustering was done using Moduland.</p