A Large-Scale CNN Ensemble for Medication Safety Analysis

Revealing Adverse Drug Reactions (ADR) is an essential part of post-marketing drug surveillance, and data from health-related forums and medical communities can be of a great significance for estimating such effects. In this paper, we propose an end-to-end CNN-based method for predicting drug safety on user comments from healthcare discussion forums. We present an architecture that is based on a vast ensemble of CNNs with varied structural parameters, where the prediction is determined by the majority vote. To evaluate the performance of the proposed solution, we present a large-scale dataset collected from a medical website that consists of over 50 thousand reviews for more than 4000 drugs. The results demonstrate that our model significantly outperforms conventional approaches and predicts medicine safety with an accuracy of 87.17% for binary and 62.88% for multi-classification tasks

The Chittagong story: studies on the ecology of rat floods and bamboo masting

Rodent population outbreaks due to the 50-year cycle of gregarious flowering and seed masting of Melocanna baccifera were first noted in the Chittagong Hill Tracts (CHT) of Bangladesh during the crop production cycle of 2008. The wave of flowering has steadily moved southward through the region each year, with seed masting still occurring in some areas of the CHT during 2010. Because of a lack of surveillance, it is not yet known whether all Melocanna bamboo forests across the region have now initiated flowering. Ecological surveys carried out during the masting event have provided some preliminary evidence that nearly all rodent species are able to exploit Melocanna bamboo seeds as a food resource, with nearly 30% of the seed fallen in forests damaged by rodents. Breeding potential of the predominant species found, Rattus rattus, appears to confirm that aseasonal breeding occurs due to the abundant supply of bamboo seed during masting events. These preliminary results obtained from ongoing research surveys are discussed in the context of the management response to the regional famine triggered by the severe crop damage caused by rodent population outbreaks

Metallic conduction and superconductivity in the pseudogap phase

We analyze the t-J model on a square lattice using bosonic spinons and fermionic holons for low density x of holes. Spinons are paired into singlets, which condense below a temperature T*. The condensate evolves out of the Mott phase - preserving its symmetry. For T > T* holons and spinons are confined (by gauge forces), so that there is no coherent charge propagation. Metallic conduction and d-wave superconductivity result from separate, sublattice-preserving, holon hopping processes which originate below T* from a coupling with the condensate. A simple effective Hamiltonian describing these processes is derived and solved. Holons form a charge Fermi liquid, becoming incoherent (confined) above T*. In the superconductor holons hop as pairs, reducing kinetic energy. The two-sublattice property is the glue that connects the three phases; its effect can be seen in various correlation functions. The theory can account for many features of the cuprate superconductors, including the origin of two-dimensional metallicity.Comment: 7 pages 5 Postscript figure

Spin-Charge Separation and Kinetic Energy in the t-J Model

I show that spin-charge separation in 2-D t-J model leads to an increase of kinetic energy. Using a sum rule, I derive an exact expression for the lowest possible KE (E_{bound}) for any state without doubly occupied sites. KE of relevant slave-boson and Schwinger-boson mean-field states -- which exhibit complete spin-charge separation -- are found to be much larger than E_{bound}. Examination of n(k) shows that the large increse in KE is due to excessive depletion of electrons from the bottom of the band (Schwinger boson) and of holes from the top (slave boson). To see whether the excess KE is simply due to poor treatment of the constraints, I solve the constraint problem analytically for the Schwinger boson case in the J = 0 limit. This restores gauge invariance, incorrectly violated in MF theories. The result is a generalized Hartree-Fock state of the Hubbard model, but one that includes spin waves. Even after constraints are imposed correctly, the KE remains much larger than E_{bound}. These results support the notion, advanced earlier [PRB 61, 8663 (2000)] that spin-charge separation in the MF state costs excessive KE, and makes the state unstable toward recombination processes which lead to superconductivity in d = 2 and a Fermi liquid state in higher dimensions.Comment: 13 pages, LateX plus three figures. To appear in Phys Rev B Typos correcte