LDL-C response by 6-month treatment of statin or statin + ezetimibe.

LDL-C response by 6-month treatment of statin or statin + ezetimibe.</p

Changes of cholesterol profiles after 6 months of statin treatment.

Changes of cholesterol profiles after 6 months of statin treatment.</p

Statin names and doses.

BackgroundAlthough the current guideline recommends the use of high-intensity statin to reduce the low-density lipoprotein cholesterol (LDL-C) level by 50% in patients with baseline value of ≥ 190 mg/dL, direct application of this recommendation to Asian populations is still questionable. This study was performed to investigate the statin response of LDL-C in Korean patients with LDL-C ≥ 190 mg/dL.MethodsA total of 1,075 Korean patients (age 60.7 ± 12.2 years, women 68%) with baseline LDL-C ≥ 190 mg/dL without cardiovascular disease was retrospectively reviewed. Lipid profiles at 6 months, side effects and clinical outcomes during the follow-up period after statin treatment were assessed according to statin intensity.ResultsMost of the patients (76.3%) were treated with moderate-intensity statins, 11.4% with high-intensity statins, and 12.3% with a statin + ezetimibe. The reductions in LDL-C percentage at 6 months were 48.0%, 56.0% and 53.3% in patients treated with moderate-intensity statins, high-intensity statins and statin + ezetimibe, respectively (P P = 0.024). During the median follow-duration of 815 days (interquartile range, 408–1,361 days), the incidences of cardiovascular events were not different among the 3 groups (log-rank P = 0.823).ConclusionsCompared to high-intensity statin, moderate-intensity statin was effective enough in reaching target goal of LDL-C without increase in cardiovascular risk and with fewer side effects in Korean patients with LDL-C ≥ 190 mg/dL.</div

Targeted oral bacteria and primer/probe set sequence used for quantification real-time PCR.

Targeted oral bacteria and primer/probe set sequence used for quantification real-time PCR.</p

Standard curves generated from the <i>Ct</i> values for amplification of the target DNA of the red complex bacteria.

(DOCX)</p

Correlation between the severity of periodontal condition and the number of each bacterial species.

Correlation between the severity of periodontal condition and the number of each bacterial species.</p

Mean numbers of bacteria in comparison between groups.

(A) Comparison of fold changes between the reversible and irreversible groups. PD2: PD2 group, PD3: PD3 group, PD4: PD4 group, con: Reversible group.</p

List of bacteria tested for the specificity of the qPCR with the primer/probe set.

(DOCX)</p

Test results of qPCR specificity with the primer/probe set.

(DOCX)</p

Overall mean numbers of bacteria in all groups.

Bars show standard deviation. log = logarithm.</p