Advancements in Standardising Patient-Reported Outcomes Measurement

Patient-reported outcomes (PRO) data can deliver crucial information for diagnostic purposes and regarding benefits and possible harms of medical interventions. Recognising the potential of the patient’s voice, PRO data are increasingly integrated in clinical practice and clinical research, and they play an increasingly important role in medical and health policy decision making. With the growing focus on patient centeredness, the requirements towards the quality of PRO data are steadily increasing as well, and outcomes researchers and other stakeholders working in related disciplines such as academia, the pharmaceutical industry and the not-for-profit sector have a growing ethical responsibility to use only those PRO instruments that generate robust data and allow for valid inferences from PRO scores. To achieve high quality PRO data, standardised processes spanning from PRO instrument development and content validation, translation and cultural adaptation, statistical analysis and interpretation of PRO data are key to ensure that data collected via patient self-report can be trusted. This habilitation thesis focuses on PRO standardisation efforts worldwide, including an overview of PRO projects that were run in the context of two key PRO measurement systems, i.e., the PRO instruments of 1) the Patient-Reported Outcomes Measurement Information System (PROMIS) initiative and 2) the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Group. In conclusion, international initiatives aimed at standardised PRO assessment are well underway all of which contribute to ensuring that high quality PRO data can be generated. It is expected that both the PROMIS and EORTC suites of PRO instruments will continue to grow, consolidate the PRO field and be a benchmark for standardised PRO assessment, validation and interpretation

Development of Boys and Young Men of Color: Implications of Developmental Science for My Brother's Keeper Initiative

This report describes the My Brother's Keeper Initiative. The report summarizes ideas gleaned from developmental science that may be useful in efforts to reach five of the six initiative's goals: school readiness; third-grade literacy; high school and college graduation; and reduction of violence. The authors discuss features of the initiative designed to promote more positive outcomes and highlight the contributions that developmental science may make to each. Policy recommendations are provided and a discussion about how developmental science may contribute to national dialogue and policy formation

The Ethnic Context and Attitudes Toward 9th Grade Math

The present study examined the relations between ethnic context and attitudes about 9th grade math in youth from different ethnic groups who had recently transitioned to high school. The large sample comprised African American, Latino, White, and Asian youth (n = 2265, 55% girls, Mage = 14.6 yrs.) A new questionnaire was developed assessing four math attitudes (perceived competence, feelings of belonging, perceive importance and anxiety in math) and two ethnic context variables (perceived same-ethnic peers in one’s math class and perceptions of the school ethnic climate). Participants listed the math course they were taking in 9th grade and then completed the questionnaire based on that class. Perceiving more same-ethnic classmates in math was related to more positive attitudes about perceived competence and feelings of belonging in math. Significant interactions between the two ethnic context variables were documented suggesting that a positive ethnic climate buffered some of the negative effects of few same-ethnic peers on perceived competence and belonging. Implications of the findings for understanding the social-motivational underpinnings of high school course-taking among multiethnic youth were discussed

Benchmarking non-adiabatic quantum dynamics using the molecular Tully models

On-the-fly non-adiabatic dynamics methods are becoming more important as tools to characterise the time evolution of a system after absorbing light. These methods, which calculate quantities such as state energies, gradients and interstate couplings at every time step, circumvent the requirement for pre-computed potential energy surfaces. There are a number of different algorithms used, the most common being Tully Surface Hopping (TSH), but all are approximate solutions to the time-dependent Schrödinger equation and benchmarking is required to understand their accuracy and performance. For this, a common set of systems and observables are required to compare them. In this work, we validate the on-the-fly direct dynamics variational multi-configuration Gaussian (DD-vMCG) method using three molecular systems recently suggested by Ibele and Curchod as molecular versions of the Tully model systems used to test one-dimensional non-adiabatic behaviour [Ibele et al., Phys. Chem. Chem. Phys. 2020, 22, 15183-15196]. Parametrised linear vibronic potential energy surfaces for each of the systems were also tested and compared to on-the-fly results. The molecules, which we term the Ibele-Curchod models, are ethene, DMABN and fulvene and the authors used them to test and compare several versions of the Ab Initio Multiple Spawning (AIMS) method alongside TSH. The three systems present different deactivation pathways after excitation to their ππ* bright states. When comparing DD-vMCG to AIMS and TSH, we obtain crucial differences in some cases, for which an explanation is provided by the classical nature and the chosen initial conditions of the TSH simulations.</p

SURVIVING POVERTY: Stress and Coping in the Lives of Housed and Homeless Mothers

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73602/1/h0080357.pd

The implementation of chlamydia screening: a cross-sectional study in the south east of England

Background England's National Chlamydia Screening Programme (NCSP) provides opportunistic testing for under 25 year-olds in healthcare and non-healthcare settings. The authors aimed to explore relationships between coverage and positivity in relation to demographic characteristics or setting, in order to inform efficient and sustainable implementation of the NCSP. Methods The authors analysed mapped NCSP testing data from the South East region of England between April 2006 and March 2007 inclusive to population characteristics. Coverage was estimated by sex, demographic characteristics and service characteristics, and variation in positivity by setting and population group. Results Coverage in females was lower in the least deprived areas compared with the most deprived areas (OR 0.48; 95% CI 0.45 to 0.50). Testing rates were lower in 20 1324-year-olds compared with 15 1319-year-olds (OR 0.69; 95% CI 0.67 to 0.72 for females and OR 0.67; 95% CI 0.64 to 0.71 for males), but positivity was higher in older males. Females were tested most often in healthcare services, which also identified the most positives. The greatest proportions of male tests were in university (27%) and military (19%) settings which only identified a total of 11% and 13% of total male positives respectively. More chlamydia-positive males were identified through healthcare services despite fewer numbers of tests. Conclusions Testing of males focused on institutional settings where there is a low yield of positives, and limited capacity for expansion. By contrast, the testing of females, especially in urban environments, was mainly through established healthcare services. Future strategies should prioritise increasing male testing in healthcare settings

Children exposed to intimate partner violence: Identifying differential effects of family environment on children\u27s trauma and psychopathology symptoms through regression mixture models

The majority of analytic approaches aimed at understanding the influence of environmental context on children\u27s socioemotional adjustment assume comparable effects of contextual risk and protective factors for all children. Using self-reported data from 289 maternal caregiver-child dyads, we examined the degree to which there are differential effects of severity of intimate partner violence (IPV) exposure, yearly household income, and number of children in the family on posttraumatic stress symptoms (PTS) and psychopathology symptoms (i.e., internalizing and externalizing problems) among school-age children between the ages of 7–12 years. A regression mixture model identified three latent classes that were primarily distinguished by differential effects of IPV exposure severity on PTS and psychopathology symptoms: (1) asymptomatic with low sensitivity to environmental factors (66% of children), (2) maladjusted with moderate sensitivity (24%), and (3) highly maladjusted with high sensitivity (10%). Children with mothers who had higher levels of education were more likely to be in the maladjusted with moderate sensitivity group than the asymptomatic with low sensitivity group. Latino children were less likely to be in both maladjusted groups compared to the asymptomatic group. Overall, the findings suggest differential effects of family environmental factors on PTS and psychopathology symptoms among children exposed to IPV. Implications for research and practice are discussed

Externalising and emotional categories, diagnostic groups and clinical profiles

<p>Abstract</p> <p>Background</p> <p>It has been proposed that gains would be made in the validity of the psychiatric classification system if many of the present 'neurotic' or personality disorders were subsumed into two over-arching groups, externalising and emotional disorders. If diagnostic sub-categories from the first digit coding structures within ICD-10 do, in fact, share clinical phenomenology that align with the major externalising/emotional distinction, this further supports the proposal and contributes to face validity. The aim of the study was to examine the distribution of particular psychopathology within and between two proposed over-arching groupings - externalising and emotional disorders - in a clinical sample.</p> <p>Method</p> <p>The distributions of HoNOS derived information in relation to the proposed clusters of emotional disorders and extrinsic disorders are examined.</p> <p>Results</p> <p>Statistically significant differences in profiles between the emotional and the externalising groupings are consistent with the proposed classification development. The HoNOS (Health of Nation Outcome Scale) measures of self harm, depression, aggression, occupational/leisure problems and drug and alcohol consumption are the five most significant discriminators between the two groups.</p> <p>Discussion</p> <p>The details of the profile differences within the two over arching groups suggest that further examination is required. Useful work could include examination in credibly large and unselected patient populations of the factor structure demonstrated in non patient samples. Prospective comprehensive trials of the contributions the proposed classification could make to clinical decision making would also help illuminate this area.</p