ARE EMOTIONAL DISPLAYS AN EVOLUTIONARY PRECURSOR TO COMPOSITIONALITY IN LANGUAGE?

Compositionality is a basic property of language, spoken and signed, according to which the meaning of a complex structure is determined by the meanings of its constituents and the way they combine (e.g., Jackendoff, 2011 for spoken language; Sandler 2012 for constituents conveyed by face and body signals in sign language; Kirby & Smith, 2012 for emergence of compositionality). Here we seek the foundations of this property in a more basic, and presumably prior, form of communication: the spontaneous expression of emotion. To this end, we ask whether features of facial expressions and body postures are combined and recombined to convey different complex meanings in extreme displays of emotions. There is evidence that facial expressions are processed in a compositional fashion (Chen & Chen, 2010). In addition, facial components such as nose wrinkles or eye opening elicit systematic confusion while decoding facial expressions of disgust and anger and fear and surprise, respectively (Jack et al., 2014), suggesting that other co-occurring signals contribute to their interpretation. In spontaneous emotional displays of athletes, the body – and not the face – better predicts participants’ correct assessments of victory and loss pictures, as conveying positive or negative emotions (Aviezer et al., 2012), suggesting at least that face and body make different contributions to interpretations of the displays. Taken together, such studies lead to the hypothesis that emotional displays are compositional - that each signal component, or possibly specific clusters of components (Du et al., 2014), may have their own interpretations, and make a contribution to the complex meaning of the whole. On the assumption that emotional displays are older than language in evolution, our research program aims to determine whether the crucial property of compositionality is indeed present in communicative displays of emotion

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

The immune response in the brain has been widely investigated and while many studies have focused on the proinflammatory cytotoxic response, the brain’s innate immune system demonstrates significant heterogeneity. Microglia, like other tissue macrophages, participate in repair and resolution processes after infection or injury to restore normal tissue homeostasis. This review examines the mechanisms that lead to reduction of self-toxicity and to repair and restructuring of the damaged extracellular matrix in the brain. Part of the resolution process involves switching macrophage functional activation to include reduction of proinflammatory mediators, increased production and release of anti-inflammatory cytokines, and production of cytoactive factors involved in repair and reconstruction of the damaged brain. Two partially overlapping and complimentary functional macrophage states have been identified and are called alternative activation and acquired deactivation. The immunosuppressive and repair processes of each of these states and how alternative activation and acquired deactivation participate in chronic neuroinflammation in the brain are discussed

Motivate To Communicate 300 Permainan dan Aktivitas untuk Anak Autis

Buku praktis ini berisi beragam ide menarik dan panduan untuk memotivasi anak-anak yang mengalami gangguan spektrum autisme dan masalah-masalah komunikasi lainnya. Formatnya yang praktis memudahkan anda untuk mengakses lebih dari 300 permainan dan aktivitas seru untuk mengembangkan keterampilan komunikasi anak anda. Gagasan-gagasan Innovatif dalam buku ini telah dikembangkan dari pengalaman klinis dan edukatif selama lebih dari 40 tahun dan didesain sedemikian rupa sehingga menyenangkan baik untuk anak-anak maupun orang dewasa.xi+160 hlm; 15x23 c

Compositionality in the language of emotion.

Emotions are signaled by complex arrays of face and body actions. The main point of contention in contemporary treatments is whether these arrays are discrete, holistic constellations reflecting emotion categories, or whether they are compositional-comprised of smaller components, each of which contributes some aspect of emotion to the complex whole. We address this question by investigating spontaneous face and body displays of athletes and place it in the wider context of human communicative signals and, in particular, of language. A defining property of human language is compositionality-the ability to combine and recombine a relatively small number of elements to create a vast number of complex meaningful expressions, and to interpret them. We ask whether this property of language can be discerned in a more ancient communicative system: intense emotional displays. In an experiment, participants interpreted a range of emotions and their strengths in pictures of athletes who had just won or lost a competition. By matching participants' judgements with minutely coded features of face and body, we find evidence for compositionality. The distribution of participants' responses indicates that most of the athletes' face and body features contribute to displays of dominance or submission. More particular emotional components related, for example, to positive valence (e.g. happy) or goal obstruction (e.g. frustrated), were also found to significantly correlate with certain face and body features. We propose that the combination of features linked to broader components (i.e, dominant or submissive) and to more particular emotions (e.g, happy or frustrated) reflects more complex emotional states. In sum, we find that the corporeal expression of intense, unfiltered emotion has compositional properties, potentially providing an ancient scaffolding upon which, millions of years later, the abstract and constrained compositional system of human language could build