1,713 research outputs found

    Prolonged Thrombocytopenia in a Child with Severe Neonatal Alloimmune Reaction and Noonan Syndrome

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    Fetomaternal alloimmune thrombocytopenia (FMAIT) caused by maternal antibodies is the leading cause of severe neonatal thrombocytopenia. A 1-month-old Caucasian girl was referred to our Hematology Clinic for persistent thrombocytopenia diagnosed after a bleeding episode. Diagnostic tests suggested FMAIT. Mild thrombocytopenia persisted for 18 months, and subsequent findings of dysmorphic facies, short stature and mild pulmonary stenosis led to the hypothesis of Noonan syndrome (NS), which was confirmed by genetic test. Other hematological abnormalities were excluded and she had no further bleeding episodes. This case illustrates the possibility of different diagnoses with the same clinical manifestations. The persistence of thrombocytopenia longer than expected associated with typical physical features led to the diagnosis of NS.info:eu-repo/semantics/publishedVersio

    Accidents in Children and Adolescents: What Context and What Approach? A Nine-Month Experience at the Emergency Department of a Level II Hospital

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    Introdu√ß√£o: Os acidentes constituem uma importante causa de morbimortalidade infantil e de recurso ao servi√ßo de urg√™ncia pedi√°trica. A n√≠vel nacional conhecem-se apenas alguns dados epidemiol√≥gicos. M√©todos: Estudo observacional transversal com an√°lise da coorte das crian√ßas observadas no servi√ßo de urg√™ncia pedi√°trica de um hospital n√≠vel II por motivo de acidente, durante um per√≠odo de nove meses, com dados obtidos atrav√©s de um inqu√©rito e submetidos a an√°lise estat√≠stica. Resultados: Das 22502 admiss√Ķes de crian√ßas at√© aos 14 anos registadas, 1746 (7,8%) foram por acidentes. A maioria era do sexo masculino e tinha mais de 5 anos. Os acidentes ocorreram maioritariamente no exterior da escola (29,1%) e interior de casa (25%), predominando a queda como tipo de acidente (55,5%) e a contus√£o como mecanismo de les√£o (54,2%). A maioria das crian√ßas (77,3%) foi submetida a exames complementares de diagn√≥stico destacando-se os radiol√≥gicos. Os diagn√≥sticos mais frequentes foram os traumatismos superficiais (47,9%) e os ferimentos (24,8%). Em 6,6% (115) dos casos os acidentes foram considerados graves. Estas admiss√Ķes por acidentes associaram-se a uma despesa imediata estimada de 124 mil euros. Discuss√£o: A frequ√™ncia elevada e o local de ocorr√™ncia dos acidentes coincidiram com a literatura. Apesar do predom√≠nio das les√Ķes minor superficiais (47,9%) verificou-se um n√ļmero significativo de crian√ßas com necessidade de cuidados hospitalares. N√£o foram registados √≥bitos. Os autores concluem que os acidentes em crian√ßas foram um motivo frequente de ida ao servi√ßo de urg√™ncia pedi√°trica com importante consumo de recursos. A sensibiliza√ß√£o dos cuidadores √© essencial na preven√ß√£o dos acidentes

    Machine-Readable Privacy Certificates for Services

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    Privacy-aware processing of personal data on the web of services requires managing a number of issues arising both from the technical and the legal domain. Several approaches have been proposed to matching privacy requirements (on the clients side) and privacy guarantees (on the service provider side). Still, the assurance of effective data protection (when possible) relies on substantial human effort and exposes organizations to significant (non-)compliance risks. In this paper we put forward the idea that a privacy certification scheme producing and managing machine-readable artifacts in the form of privacy certificates can play an important role towards the solution of this problem. Digital privacy certificates represent the reasons why a privacy property holds for a service and describe the privacy measures supporting it. Also, privacy certificates can be used to automatically select services whose certificates match the client policies (privacy requirements). Our proposal relies on an evolution of the conceptual model developed in the Assert4Soa project and on a certificate format specifically tailored to represent privacy properties. To validate our approach, we present a worked-out instance showing how privacy property Retention-based unlinkability can be certified for a banking financial service.Comment: 20 pages, 6 figure

    Spontaneous Learning of Visual Structures in Domestic Chicks

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    Effective communication crucially depends on the ability to produce and recognize structured signals, as apparent in language and birdsong. Although it is not clear to what extent similar syntactic-like abilities can be identified in other animals, recently we reported that domestic chicks can learn abstract visual patterns and the statistical structure defined by a temporal sequence of visual shapes. However, little is known about chicks’ ability to process spatial/positional information from visual configurations. Here, we used filial imprinting as an unsupervised learning mechanism to study spontaneous encoding of the structure of a configuration of different shapes. After being exposed to a triplet of shapes (ABC or CAB), chicks could discriminate those triplets from a permutation of the same shapes in different order (CAB or ABC), revealing a sensitivity to the spatial arrangement of the elements. When tested with a fragment taken from the imprinting triplet that followed the familiar adjacency-relationships (AB or BC) vs. one in which the shapes maintained their position with respect to the stimulus edges (AC), chicks revealed a preference for the configuration with familiar edge elements, showing an edge bias previously found only with temporal sequences

    Predicting length of treatment for neonatal abstinence syndrome in methadone-exposed neonates.

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    OBJECTIVE: The objective of the study was to identify maternal variables predicting length of treatment for neonatal abstinence syndrome (NAS). STUDY DESIGN: This was a retrospective cohort study of infants treated for NAS during 2000-2006 whose mothers were on methadone maintenance at delivery. Mixed-effects linear regression was used to examine the interaction of maternal and neonatal variables with length of treatment. RESULTS: Of 204 neonates born to methadone exposed mothers, the average dose at delivery was 127 mg daily (25-340 mg) with median length of treatment 32 days (1-122 days). Trimester of initial exposure (P = .33), methadone dose at delivery (P = .198), body mass index (P = .31), antidepressant use (P = .40), cigarette use (P = .76), race (P = .78), and maternal age (P = .84) did not predict length of treatment. In the multivariate analysis, gestational age at delivery and benzodiazepine use were significant predictors of length of treatment. CONCLUSION: Later gestational age and concomitant benzodiazepine use were associated with longer treatment

    Thermoelectric transport perpendicular to thin film heterostructures using Monte Carlo technique

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    The Monte Carlo technique is used to calculate electrical as well as thermoelectric transport properties across thin film heterostructures. We study a thin InGaAsP barrier layer sandwiched between two InGaAs contact layers, when the barrier thickness is in 50nm-2000nm range. We found that with decreasing size, the effective Seebeck coefficient is increased substantially. The transition between pure ballistic thermionic transport and fully diffusive thermoelectric transport is also described

    Microstructure and hard magnetic properties in bulk rods of Nd 60Fe 30Al 10 glass forming alloys

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    The Nd60Fe30Al10 alloy exhibits a large glass forming ability which allows to obtain relatively thick cast rods containing large volume fractions of amorphous phases. In this work the microstructure and the hard magnetic properties of as-cast rods are characterized. The alloy is processed by suction casting into a chilled copper mould to obtain cylinders 5 mm diameter and 50 mm length. This diameter is selected because it is an upper limit for this processing route, beyond which the hard properties largely deteriorate. A room temperature coercivity of 0.34 T is obtained. The sample microstructure is heterogeneous, with very different size scales near the surface and along the central zone. However, in both regions a large fraction of an amorphous ferromagnetic phase is observed; it is found that paramagnetic nanocrystalline phases, mainly Nd or Nd-rich particles embedded in the amorphous matrix, are somewhat coarser in the central zone. These larger nanocrystals, less efficient to pin domain walls, are proposed to be responsible for the lower coercive fields observed, as compared with those found in cylinders 1 to 3 mm diameter where no inhomogeneities are found. This conclusion is supported by microstructure, calorimetric and magnetic observations.Fil: Levingston, J. M.. Universidad Nacional de C√≥rdoba. Facultad de Matem√°tica, Astronom√≠a y F√≠sica; ArgentinaFil: Valente, R.. Comisi√≥n Nacional de Energ√≠a At√≥mica. Gerencia del √Ārea de Investigaci√≥n y Aplicaciones No Nucleares. Gerencia de F√≠sica (Centro At√≥mico Bariloche); Argentina. Comisi√≥n Nacional de Energ√≠a At√≥mica. Gerencia del √Ārea de Energ√≠a Nuclear. Instituto Balseiro; ArgentinaFil: Ghilarducci, Ada Albertina. Comisi√≥n Nacional de Energ√≠a At√≥mica. Gerencia del √Ārea de Investigaci√≥n y Aplicaciones No Nucleares. Gerencia de F√≠sica (Centro At√≥mico Bariloche); Argentina. Comisi√≥n Nacional de Energ√≠a At√≥mica. Gerencia del √Ārea de Energ√≠a Nuclear. Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Cient√≠ficas y T√©cnicas. Centro Cient√≠fico Tecnol√≥gico Conicet - Patagonia Norte; ArgentinaFil: Fabietti, Luis Maria Rodolfo. Universidad Nacional de C√≥rdoba. Facultad de Matem√°tica, Astronom√≠a y F√≠sica. Secci√≥n F√≠sica; Argentina. Consejo Nacional de Investigaciones Cient√≠ficas y T√©cnicas. Centro Cient√≠fico Tecnol√≥gico Conicet - C√≥rdoba. Instituto de F√≠sica Enrique Gaviola. Universidad Nacional de C√≥rdoba. Instituto de F√≠sica Enrique Gaviola; ArgentinaFil: Salva, Horacio Ramon. Comisi√≥n Nacional de Energ√≠a At√≥mica. Gerencia del √Ārea de Investigaci√≥n y Aplicaciones No Nucleares. Gerencia de F√≠sica (Centro At√≥mico Bariloche); Argentina. Comisi√≥n Nacional de Energ√≠a At√≥mica. Gerencia del √Ārea de Energ√≠a Nuclear. Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Cient√≠ficas y T√©cnicas. Centro Cient√≠fico Tecnol√≥gico Conicet - Patagonia Norte; ArgentinaFil: Urreta, S. E.. Universidad Nacional de C√≥rdoba. Facultad de Matem√°tica, Astronom√≠a y F√≠sica; Argentin

    Dietary Supplementation with Probiotics Improves Hematopoiesis in Malnourished Mice

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    BACKGROUND: Lactobacillus rhamnosus CRL1505 (Lr) administered during the repletion of immunocompromised-malnourished mice improves the resistance against intestinal and respiratory infections. This effect is associated with an increase in the number and functionality of immune cells, indicating that Lr could have some influence on myeloid and lymphoid cell production and maturation. OBJECTIVE: This study analyzed the extent of the damage caused by malnutrition on myeloid and lymphoid cell development in the spleen and bone marrow (BM). We also evaluated the impact of immunobiotics on the recovery of hematopoiesis affected in malnourished mice. METHODS: Protein malnourished mice were fed on a balanced conventional diet for 7 or 14 consecutive d with or without supplemental Lr or fermented goat's milk (FGM). Malnourished mice and well-nourished mice were used as controls. Histological and flow cytometry studies were carried out in BM and spleen to study myeloid and lymphoid cells. RESULTS: Malnutrition induced quantitative alterations in spleen B and T cells; however, no alteration was observed in the ability of splenic B cells to produce immunoglobulins after challenge with LPS or CpG. The analysis of BM B cell subsets based on B220, CD24, IgM and IgD expression showed that malnutrition affected B cell development. In addition, BM myeloid cells decreased in malnourished mice. On the contrary, protein deprivation increased BM T cell number. These alterations were reverted with Lr or FGM repletion treatments since normal numbers of BM myeloid, T and B cells were observed in these groups. CONCLUSIONS: Protein malnutrition significantly alters B cell development in BM. The treatment of malnourished mice with L. rhamnosus CRL1505 was able to induce a recovery of B cells that would explain its ability to increase immunity against infections. This work highlights the possibility of using immunobiotics to accelerate the recovery of lymphopoyesis in immunocompromised-malnourished hosts
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