Responding to the Global Crisis: Jacques Maritain, World War II, and New York\u27s École Libre

This article offers an interdisciplinary study of the French Catholic philosopher Jacques Maritain during World War II in order to provide an historical resource for understanding the global dimensions and possibilities at work in modern Catholicism. In 1941, while living in New York City, Maritain helped to cofound and lead the École Libre des Hautes Études (the “Free French University”). An initiative primarily created by American and French intellectuals, the university became an important hub for rescuing and employing nearly two hundred individuals from across the world. Elected president in late-1942, Maritain worked closely with the New School for Social Research, the Rockefeller Foundation, the International Rescue and Relief Committee, Free France (including agents in the Resistance), and foreign diplomats. The university provided a unique material context for animating a global pivot in Maritain’s intellectual project. While Maritain has been well-recognized as a key thinker of modernization in the Catholic Church, this article reconstructs an intellectual history of Maritain’s novel work as a global thinker on pressing war-time issues of transnational cooperation, the European colonies, and anti-Semitism. This article not only presents an empirically rich narrative of the global dimensions of Maritain’s intellectual project at a time of crisis but also furnishes an instructive example for thinking through ongoing discourses on global Catholicism

Xeroderma Pigmentosum Group C Deficiency Alters Cigarette Smoke DNA Damage Cell Fate and Accelerates Emphysema Development

Cigarette smoke (CS) exposure is a major risk factor for the development of emphysema, a common disease characterized by loss of cells comprising the lung parenchyma. The mechanisms of cell injury leading to emphysema are not completely understood but are thought to involve persistent cytotoxic or mutagenic DNA damage induced by CS. Using complementary cell culture and mouse models of CS exposure, we investigated the role of the DNA repair protein, xeroderma pigmentosum group C (XPC), on CS-induced DNA damage repair and emphysema. Expression of XPC was decreased in mouse lungs after chronic CS exposure and XPC knockdown in cultured human lung epithelial cells decreased their survival after CS exposure due to activation of the intrinsic apoptosis pathway. Similarly, cell autophagy and apoptosis were increased in XPC-deficient mouse lungs and were further increased by CS exposure. XPC deficiency was associated with structural and functional changes characteristic of emphysema, which were worsened by age, similar to levels observed with chronic CS exposure. Taken together, these findings suggest that repair of DNA damage by XPC plays an important and previously unrecognized role in the maintenance of alveolar structures. These findings support that loss of XPC, possibly due to chronic CS exposure, promotes emphysema development and further supports a link between DNA damage, impaired DNA repair, and development of emphysema

Hearing instruments for unilateral severe-to-profound sensorineural hearing loss in adults

Objectives: A systematic review of the literature and meta-analysis was conducted to assess the nature and quality of the evidence for the use of hearing instruments in adults with a unilateral severe-to-profound sensorineural hearing loss. Design: The PubMed, EMBASE, MEDLINE, Cochrane, CINAHL and DARE databases were searched with no restrictions on language. The search included articles from the start of each database until 11th February 2015. Studies were included that: (a) assessed the impact of any form of hearing instrument, including devices that re-route signals between the ears or restore aspects of hearing to a deaf ear, in adults with a sensorineural severe-to-profound loss in one ear and normal or near-normal hearing in the other ear; (b) compared different devices or compared a device to placebo or the unaided condition; (c) measured outcomes in terms of speech perception, spatial listening, or quality of life; (d) were prospective controlled or observational studies. Studies that met prospectively-defined criteria were subjected to random-effects meta-analyses. Results: Twenty-seven studies reported in thirty articles were included. The evidence was graded as low-to-moderate quality having been obtained primarily from observational before-after comparisons. The meta-analysis identified statistically-significant benefits to speech perception in noise for devices that re-routed the speech signals of interest from the worse ear to the better ear using either air or bone conduction (mean benefit 2.5 dB). However, these devices also degraded speech understanding significantly and to a similar extent (mean deficit 3.1 dB) when noise was re-routed to the better ear. Data on the effects of cochlear implantation on speech perception could not be pooled as the prospectively-defined criteria for meta-analysis were not met. Inconsistency in the assessment of outcomes relating to sound localisation also precluded the synthesis of evidence across studies. Evidence for the relative efficacy of different devices was sparse but a statistically significant advantage was observed for re-routing speech signals using abutment-mounted bone conduction devices when compared to outcomes after pre-operative trials of air-conduction devices when speech and noise were co-located (mean benefit 1.5 dB). Patients reported significant improvements in hearing-related quality of life with both re-routing devices and following cochlear implantation. Only two studies measured health-related quality of life and findings were inconclusive. Conclusions: Devices that re-route sounds from an ear with a severe-to-profound hearing loss to an ear with minimal hearing loss may improve speech perception in noise when signals of interest are located towards the impaired ear. However, the same device may also degrade speech perception as all signals are re-routed indiscriminately, including noise. While the restoration of functional hearing in both ears through cochlear implantation could be expected to provide benefits to speech perception, the inability to synthesise evidence across existing studies means that such a conclusion cannot yet be made. For the same reason, it remains unclear whether cochlear implantation can improve the ability to localise sounds despite restoring bilateral input. Prospective controlled studies that measure outcomes consistently and control for selection and observation biases are required to improve the quality of the evidence for the provision of hearing instruments to patients with unilateral deafness and to support any future recommendations for the clinical management of these patients

Biomarkers of exposure to new and emerging tobacco delivery products

Accurate and reliable measurements of exposure to tobacco products are essential for identifying and confirming patterns of tobacco product use and for assessing their potential biological effects in both human populations and experimental systems. Due to the introduction of new tobaccoderived products and the development of novel ways to modify and use conventional tobacco products, precise and specific assessments of exposure to tobacco are now more important than ever. Biomarkers that were developed and validated to measure exposure to cigarettes are being evaluated to assess their use for measuring exposure to these new products. Here, we review current methods for measuring exposure to new and emerging tobacco products, such as electronic cigarettes, little cigars, water pipes, and cigarillos. Rigorously validated biomarkers specific to these new products have not yet been identified. Here, we discuss the strengths and limitations of current approaches, including whether they provide reliable exposure estimates for new and emerging products. We provide specific guidance for choosing practical and economical biomarkers for different study designs and experimental conditions. Our goal is to help both new and experienced investigators measure exposure to tobacco products accurately and avoid common experimental errors. With the identification of the capacity gaps in biomarker research on new and emerging tobacco products, we hope to provide researchers, policymakers, and funding agencies with a clear action plan for conducting and promoting research on the patterns of use and health effects of these products

Sartre and the Phenomenology of Pain: A Closer Look

Conventionally distinguished as a problem for medical professionals, experiences of embodied pain have prompted a significant set of themes and perspectives in the Continental tradition of philosophy. The discipline of phenomenology, in particular, offers thought-provoking approaches for understanding the fullness and diversity of living one’s pain in everyday life. In contrast to scientific practices that tend to take for granted the subjective structures of human consciousness in action, the phenomenological framework of lived experience offers profoundly subtle accounts for explaining how a person’s pain alters their ways of relating to themselves, to others, and to the wider world around them. In recent years, scholars of phenomenology have undertaken extensive research on the complex relationality between health and human consciousness, including the behavioral grids and existential textures that come with that relationship. Greatly influenced by twentieth century phenomenology, this new development in the scholarship has undergone three distinct waves. The first wave focused on the work of Martin Heidegger and Hans-Georg Gadamer to develop a hermeneutic of healthcare practice; the second wave incorporated Maurice Merleau-Ponty to understand illness from an increasingly carnal point of view; and the third and most recent wave has relied primarily on Edmund Husserl to construct the intentionality involved with the consciousness of pain