High-pressure xenon gas time projection chamber with scalable design and its performance at around the Q value of 136^{136}Xe double-beta decay

We have been developing a high-pressure xenon gas time projection chamber (TPC) to search for neutrinoless double beta ($0\nu\beta\beta$) decay of $^{136}$Xe. The unique feature of this TPC is in the detection part of ionization electrons, called ELCC. ELCC is composed of multiple units, and one unit covers 48.5 $\mathrm{cm}^2$. A 180 L size prototype detector with 12 units, 672 channels, of ELCC was constructed and operated with 7.6 bar natural xenon gas to evaluate the performance of the detector at around the Q value of $^{136}$Xe $0\nu\beta\beta$. The obtained FWHM energy resolution is (0.73 $\pm$ 0.11) % at 1836 keV. This corresponds to (0.60 $\pm$ 0.03) % to (0.70 $\pm$ 0.21) % of energy resolution at the Q value of $^{136}Xe$ $0\nu\beta\beta$. This result shows the scalability of the AXEL detector with ELCC while maintaining high energy resolution. Factors determining the energy resolution were quantitatively evaluated and the result indicates further improvement is feasible. Reconstructed track images show distinctive structures at the endpoint of electron tracks, which will be an important feature to distinguish $0\nu\beta\beta$ signals from gamma-ray backgrounds.Comment: 33 pages, 24 figures, preprint accepted by PTE

Paracrine IL-33 Stimulation Enhances Lipopolysaccharide-Mediated Macrophage Activation

BACKGROUND: IL-33, a member of the IL-1 family of cytokines, provokes Th2-type inflammation accompanied by accumulation of eosinophils through IL-33R, which consists of ST2 and IL-1RAcP. We previously demonstrated that macrophages produce IL-33 in response to LPS. Some immune responses were shown to differ between ST2-deficient mice and soluble ST2-Fc fusion protein-treated mice. Even in anti-ST2 antibody (Ab)-treated mice, the phenotypes differed between distinct Ab clones, because the characterization of such Abs (i.e., depletion, agonistic or blocking Abs) was unclear in some cases. METHODOLOGY/PRINCIPAL FINDINGS: To elucidate the precise role of IL-33, we newly generated neutralizing monoclonal Abs for IL-33. Exogenous IL-33 potentiated LPS-mediated cytokine production by macrophages. That LPS-mediated cytokine production by macrophages was suppressed by inhibition of endogenous IL-33 by the anti-IL-33 neutralizing mAbs. CONCLUSIONS/SIGNIFICANCE: Our findings suggest that LPS-mediated macrophage activation is accelerated by macrophage-derived paracrine IL-33 stimulation

Two-particle correlations in azimuthal angle and pseudorapidity in inelastic p + p interactions at the CERN Super Proton Synchrotron

Results on two-particle ΔηΔϕ correlations in inelastic p + p interactions at 20, 31, 40, 80, and 158 GeV/c are presented. The measurements were performed using the large acceptance NA61/SHINE hadron spectrometer at the CERN Super Proton Synchrotron. The data show structures which can be attributed mainly to effects of resonance decays, momentum conservation, and quantum statistics. The results are compared with the Epos and UrQMD models.ISSN:1434-6044ISSN:1434-605

Neutrino Physics

Abstract The observation of neutrino oscillations is firm evidence of non-zero neutrino mass. Neutrino mass and mixing have been studied by neutrino oscillation experiments so far. One of the remaining questions is whether neutrinos violate CP symmetry. Exploring new CP violation is also a subject of kaon physics. There are other common physics topics between neutrino and kaon experiments. In this talk, recent progress and future prospects of neutrino experiments for topics related to kaon physics will be discussed.</jats:p